Clinical aspect, pathogenesis and therapy options of alopecia induced by hormonal therapy for breast cancer

Adjuvant hormonal therapy is one of the most important treatments of hormone-receptor-positive breast cancer and includes selective estrogen receptor modulators, aromatase inhibitors, and luteinizing hormone-releasing hormone analogs. In patients receiving these drugs, a progressive recession of fro...

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Autores principales:	Alfredo Rossi, Gemma Caro, Francesca Magri, Maria Caterina Fortuna, Marta Carlesimo
Formato:	article
Lenguaje:	EN
Publicado:	Open Exploration Publishing Inc. 2021
Materias:	alopecia hormonal therapy breast cancer Internal medicine RC31-1245
Acceso en línea:	https://doaj.org/article/f128ca6dd8064316846e96e04b306f01
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spelling	oai:doaj.org-article:f128ca6dd8064316846e96e04b306f012021-11-08T10:10:44ZClinical aspect, pathogenesis and therapy options of alopecia induced by hormonal therapy for breast cancer10.37349/etat.2021.000592692-3114https://doaj.org/article/f128ca6dd8064316846e96e04b306f012021-10-01T00:00:00Zhttps://www.explorationpub.com/Journals/etat/Article/100259https://doaj.org/toc/2692-3114Adjuvant hormonal therapy is one of the most important treatments of hormone-receptor-positive breast cancer and includes selective estrogen receptor modulators, aromatase inhibitors, and luteinizing hormone-releasing hormone analogs. In patients receiving these drugs, a progressive recession of frontal-temporal hairlines is often observed, such as a certain grade of hair miniaturization in the same areas and the central scalp area, producing a pseudo-female androgenic alopecia, which has to be considered oncotherapy-induced alopecia. The aim of this work, is to describe the clinical aspects and pathogenesis of this type of alopecia and to analyze the different drugs which have been proposed until now. The authors concude that topical hormones should not be considered as a therapeutic approach because of their direct or indirect oncogenic potential. A therapeutic approach that could be both safe and effective is proposed.Alfredo RossiGemma CaroFrancesca MagriMaria Caterina FortunaMarta CarlesimoOpen Exploration Publishing Inc.articlealopeciahormonal therapybreast cancerInternal medicineRC31-1245ENExploration of Targeted Anti-tumor Therapy, Vol 2, Iss 5, Pp 490-495 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	alopecia hormonal therapy breast cancer Internal medicine RC31-1245
spellingShingle	alopecia hormonal therapy breast cancer Internal medicine RC31-1245 Alfredo Rossi Gemma Caro Francesca Magri Maria Caterina Fortuna Marta Carlesimo Clinical aspect, pathogenesis and therapy options of alopecia induced by hormonal therapy for breast cancer
description	Adjuvant hormonal therapy is one of the most important treatments of hormone-receptor-positive breast cancer and includes selective estrogen receptor modulators, aromatase inhibitors, and luteinizing hormone-releasing hormone analogs. In patients receiving these drugs, a progressive recession of frontal-temporal hairlines is often observed, such as a certain grade of hair miniaturization in the same areas and the central scalp area, producing a pseudo-female androgenic alopecia, which has to be considered oncotherapy-induced alopecia. The aim of this work, is to describe the clinical aspects and pathogenesis of this type of alopecia and to analyze the different drugs which have been proposed until now. The authors concude that topical hormones should not be considered as a therapeutic approach because of their direct or indirect oncogenic potential. A therapeutic approach that could be both safe and effective is proposed.
format	article
author	Alfredo Rossi Gemma Caro Francesca Magri Maria Caterina Fortuna Marta Carlesimo
author_facet	Alfredo Rossi Gemma Caro Francesca Magri Maria Caterina Fortuna Marta Carlesimo
author_sort	Alfredo Rossi
title	Clinical aspect, pathogenesis and therapy options of alopecia induced by hormonal therapy for breast cancer
title_short	Clinical aspect, pathogenesis and therapy options of alopecia induced by hormonal therapy for breast cancer
title_full	Clinical aspect, pathogenesis and therapy options of alopecia induced by hormonal therapy for breast cancer
title_fullStr	Clinical aspect, pathogenesis and therapy options of alopecia induced by hormonal therapy for breast cancer
title_full_unstemmed	Clinical aspect, pathogenesis and therapy options of alopecia induced by hormonal therapy for breast cancer
title_sort	clinical aspect, pathogenesis and therapy options of alopecia induced by hormonal therapy for breast cancer
publisher	Open Exploration Publishing Inc.
publishDate	2021
url	https://doaj.org/article/f128ca6dd8064316846e96e04b306f01
work_keys_str_mv	AT alfredorossi clinicalaspectpathogenesisandtherapyoptionsofalopeciainducedbyhormonaltherapyforbreastcancer AT gemmacaro clinicalaspectpathogenesisandtherapyoptionsofalopeciainducedbyhormonaltherapyforbreastcancer AT francescamagri clinicalaspectpathogenesisandtherapyoptionsofalopeciainducedbyhormonaltherapyforbreastcancer AT mariacaterinafortuna clinicalaspectpathogenesisandtherapyoptionsofalopeciainducedbyhormonaltherapyforbreastcancer AT martacarlesimo clinicalaspectpathogenesisandtherapyoptionsofalopeciainducedbyhormonaltherapyforbreastcancer
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Clinical aspect, pathogenesis and therapy options of alopecia induced by hormonal therapy for breast cancer

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