Multiplex precise base editing in cynomolgus monkeys

Due to the polygenic nature of most diseases, simultaneous correction or introduction of single nucleotide variants is needed. Here, the authors demonstrated the feasibility of multiplex base editing for polygenes disease modeling in cynomolgus monkey embryos with high specificity.

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Autores principales:	Wenhui Zhang, Tomomi Aida, Ricardo C. H. del Rosario, Jonathan J. Wilde, Chenhui Ding, Xiaohui Zhang, Zulqurain Baloch, Yan Huang, Yu Tang, Duanduan Li, Hongyu Lu, Yang Zhou, Minqing Jiang, Dongdong Xu, Zhihao Fang, Zhanhong Zheng, Qunshan Huang, Guoping Feng, Shihua Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f12a1f3a3f2f43fcbc1cc1633d33b500
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spelling	oai:doaj.org-article:f12a1f3a3f2f43fcbc1cc1633d33b5002021-12-02T17:01:35ZMultiplex precise base editing in cynomolgus monkeys10.1038/s41467-020-16173-02041-1723https://doaj.org/article/f12a1f3a3f2f43fcbc1cc1633d33b5002020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16173-0https://doaj.org/toc/2041-1723Due to the polygenic nature of most diseases, simultaneous correction or introduction of single nucleotide variants is needed. Here, the authors demonstrated the feasibility of multiplex base editing for polygenes disease modeling in cynomolgus monkey embryos with high specificity.Wenhui ZhangTomomi AidaRicardo C. H. del RosarioJonathan J. WildeChenhui DingXiaohui ZhangZulqurain BalochYan HuangYu TangDuanduan LiHongyu LuYang ZhouMinqing JiangDongdong XuZhihao FangZhanhong ZhengQunshan HuangGuoping FengShihua YangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wenhui Zhang Tomomi Aida Ricardo C. H. del Rosario Jonathan J. Wilde Chenhui Ding Xiaohui Zhang Zulqurain Baloch Yan Huang Yu Tang Duanduan Li Hongyu Lu Yang Zhou Minqing Jiang Dongdong Xu Zhihao Fang Zhanhong Zheng Qunshan Huang Guoping Feng Shihua Yang Multiplex precise base editing in cynomolgus monkeys
description	Due to the polygenic nature of most diseases, simultaneous correction or introduction of single nucleotide variants is needed. Here, the authors demonstrated the feasibility of multiplex base editing for polygenes disease modeling in cynomolgus monkey embryos with high specificity.
format	article
author	Wenhui Zhang Tomomi Aida Ricardo C. H. del Rosario Jonathan J. Wilde Chenhui Ding Xiaohui Zhang Zulqurain Baloch Yan Huang Yu Tang Duanduan Li Hongyu Lu Yang Zhou Minqing Jiang Dongdong Xu Zhihao Fang Zhanhong Zheng Qunshan Huang Guoping Feng Shihua Yang
author_facet	Wenhui Zhang Tomomi Aida Ricardo C. H. del Rosario Jonathan J. Wilde Chenhui Ding Xiaohui Zhang Zulqurain Baloch Yan Huang Yu Tang Duanduan Li Hongyu Lu Yang Zhou Minqing Jiang Dongdong Xu Zhihao Fang Zhanhong Zheng Qunshan Huang Guoping Feng Shihua Yang
author_sort	Wenhui Zhang
title	Multiplex precise base editing in cynomolgus monkeys
title_short	Multiplex precise base editing in cynomolgus monkeys
title_full	Multiplex precise base editing in cynomolgus monkeys
title_fullStr	Multiplex precise base editing in cynomolgus monkeys
title_full_unstemmed	Multiplex precise base editing in cynomolgus monkeys
title_sort	multiplex precise base editing in cynomolgus monkeys
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f12a1f3a3f2f43fcbc1cc1633d33b500
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Multiplex precise base editing in cynomolgus monkeys

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