Luteapyrone, a Novel ƴ-Pyrone Isolated from the Filamentous Fungus <i>Metapochonia lutea</i>

In the process of screening for new bioactive microbial metabolites we found a novel ƴ-pyrone derivative for which we propose the trivial name luteapyrone, in a recently described microscopic filamentous fungus, <i>Metapochonia lutea</i> BiMM-F96/DF4. The compound was isolated from the c...

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Autores principales:	Roman Labuda, Markus Bacher, Hannes Gratzl, Maria Doppler, Alexandra Parich, Mohammed Aufy, Rosa Lemmens-Gruber, Rainer Schuhmacher, Kathrin Rychli, Martin Wagner, Thomas Rosenau, Joseph Strauss, Christoph Schüller
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	actinopyrones fungal metabolites verticipyrone <i>Verticillium</i>-like species Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/f12ff6b9367d4d57beda4a9b8aef0066
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spelling	oai:doaj.org-article:f12ff6b9367d4d57beda4a9b8aef00662021-11-11T18:33:55ZLuteapyrone, a Novel ƴ-Pyrone Isolated from the Filamentous Fungus <i>Metapochonia lutea</i>10.3390/molecules262165891420-3049https://doaj.org/article/f12ff6b9367d4d57beda4a9b8aef00662021-10-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6589https://doaj.org/toc/1420-3049In the process of screening for new bioactive microbial metabolites we found a novel ƴ-pyrone derivative for which we propose the trivial name luteapyrone, in a recently described microscopic filamentous fungus, <i>Metapochonia lutea</i> BiMM-F96/DF4. The compound was isolated from the culture extract of the fungus grown on modified yeast extract sucrose medium by means of flash chromatography followed by preparative HPLC. The chemical structure was elucidated by NMR and LC-MS. The new compound was found to be non-cytotoxic against three mammalian cell lines (HEK 263, KB-3.1 and Caco-2). Similarly, no antimicrobial activity was observed in tested microorganisms (gram positive and negative bacteria, yeast and fungi).Roman LabudaMarkus BacherHannes GratzlMaria DopplerAlexandra ParichMohammed AufyRosa Lemmens-GruberRainer SchuhmacherKathrin RychliMartin WagnerThomas RosenauJoseph StraussChristoph SchüllerMDPI AGarticleactinopyronesfungal metabolitesverticipyrone<i>Verticillium</i>-like speciesOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6589, p 6589 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	actinopyrones fungal metabolites verticipyrone <i>Verticillium</i>-like species Organic chemistry QD241-441
spellingShingle	actinopyrones fungal metabolites verticipyrone <i>Verticillium</i>-like species Organic chemistry QD241-441 Roman Labuda Markus Bacher Hannes Gratzl Maria Doppler Alexandra Parich Mohammed Aufy Rosa Lemmens-Gruber Rainer Schuhmacher Kathrin Rychli Martin Wagner Thomas Rosenau Joseph Strauss Christoph Schüller Luteapyrone, a Novel ƴ-Pyrone Isolated from the Filamentous Fungus <i>Metapochonia lutea</i>
description	In the process of screening for new bioactive microbial metabolites we found a novel ƴ-pyrone derivative for which we propose the trivial name luteapyrone, in a recently described microscopic filamentous fungus, <i>Metapochonia lutea</i> BiMM-F96/DF4. The compound was isolated from the culture extract of the fungus grown on modified yeast extract sucrose medium by means of flash chromatography followed by preparative HPLC. The chemical structure was elucidated by NMR and LC-MS. The new compound was found to be non-cytotoxic against three mammalian cell lines (HEK 263, KB-3.1 and Caco-2). Similarly, no antimicrobial activity was observed in tested microorganisms (gram positive and negative bacteria, yeast and fungi).
format	article
author	Roman Labuda Markus Bacher Hannes Gratzl Maria Doppler Alexandra Parich Mohammed Aufy Rosa Lemmens-Gruber Rainer Schuhmacher Kathrin Rychli Martin Wagner Thomas Rosenau Joseph Strauss Christoph Schüller
author_facet	Roman Labuda Markus Bacher Hannes Gratzl Maria Doppler Alexandra Parich Mohammed Aufy Rosa Lemmens-Gruber Rainer Schuhmacher Kathrin Rychli Martin Wagner Thomas Rosenau Joseph Strauss Christoph Schüller
author_sort	Roman Labuda
title	Luteapyrone, a Novel ƴ-Pyrone Isolated from the Filamentous Fungus <i>Metapochonia lutea</i>
title_short	Luteapyrone, a Novel ƴ-Pyrone Isolated from the Filamentous Fungus <i>Metapochonia lutea</i>
title_full	Luteapyrone, a Novel ƴ-Pyrone Isolated from the Filamentous Fungus <i>Metapochonia lutea</i>
title_fullStr	Luteapyrone, a Novel ƴ-Pyrone Isolated from the Filamentous Fungus <i>Metapochonia lutea</i>
title_full_unstemmed	Luteapyrone, a Novel ƴ-Pyrone Isolated from the Filamentous Fungus <i>Metapochonia lutea</i>
title_sort	luteapyrone, a novel ƴ-pyrone isolated from the filamentous fungus <i>metapochonia lutea</i>
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f12ff6b9367d4d57beda4a9b8aef0066
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Luteapyrone, a Novel ƴ-Pyrone Isolated from the Filamentous Fungus <i>Metapochonia lutea</i>

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