The regulatory light chain mediates inactivation of myosin motors during active shortening of cardiac muscle

Heart muscle cells are inactivated when they shorten during ejection, accelerating relaxation to facilitate refilling before the next beat. The authors propose that sequential folding of myosin motors onto the filament backbone may be responsible for shortening-induced de-activation in the heart.

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Detalles Bibliográficos
Autores principales:	Thomas Kampourakis, Malcolm Irving
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f131c3dff37648908503f6f87fe24b43
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spelling	oai:doaj.org-article:f131c3dff37648908503f6f87fe24b432021-12-02T14:55:09ZThe regulatory light chain mediates inactivation of myosin motors during active shortening of cardiac muscle10.1038/s41467-021-25601-82041-1723https://doaj.org/article/f131c3dff37648908503f6f87fe24b432021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25601-8https://doaj.org/toc/2041-1723Heart muscle cells are inactivated when they shorten during ejection, accelerating relaxation to facilitate refilling before the next beat. The authors propose that sequential folding of myosin motors onto the filament backbone may be responsible for shortening-induced de-activation in the heart.Thomas KampourakisMalcolm IrvingNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Thomas Kampourakis Malcolm Irving The regulatory light chain mediates inactivation of myosin motors during active shortening of cardiac muscle
description	Heart muscle cells are inactivated when they shorten during ejection, accelerating relaxation to facilitate refilling before the next beat. The authors propose that sequential folding of myosin motors onto the filament backbone may be responsible for shortening-induced de-activation in the heart.
format	article
author	Thomas Kampourakis Malcolm Irving
author_facet	Thomas Kampourakis Malcolm Irving
author_sort	Thomas Kampourakis
title	The regulatory light chain mediates inactivation of myosin motors during active shortening of cardiac muscle
title_short	The regulatory light chain mediates inactivation of myosin motors during active shortening of cardiac muscle
title_full	The regulatory light chain mediates inactivation of myosin motors during active shortening of cardiac muscle
title_fullStr	The regulatory light chain mediates inactivation of myosin motors during active shortening of cardiac muscle
title_full_unstemmed	The regulatory light chain mediates inactivation of myosin motors during active shortening of cardiac muscle
title_sort	regulatory light chain mediates inactivation of myosin motors during active shortening of cardiac muscle
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f131c3dff37648908503f6f87fe24b43
work_keys_str_mv	AT thomaskampourakis theregulatorylightchainmediatesinactivationofmyosinmotorsduringactiveshorteningofcardiacmuscle AT malcolmirving theregulatorylightchainmediatesinactivationofmyosinmotorsduringactiveshorteningofcardiacmuscle AT thomaskampourakis regulatorylightchainmediatesinactivationofmyosinmotorsduringactiveshorteningofcardiacmuscle AT malcolmirving regulatorylightchainmediatesinactivationofmyosinmotorsduringactiveshorteningofcardiacmuscle
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The regulatory light chain mediates inactivation of myosin motors during active shortening of cardiac muscle

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