GWAS of serum ALT and AST reveals an association of SLC30A10 Thr95Ile with hypermanganesemia symptoms
Circulating liver enzymes, like alanine aminotransferase (ALT) and aspartate aminotransferase (AST), are highly heritable and predictive of disease. Here, the authors perform a genome-wide association study on ALT and AST, revealing a rare variant in SLC30A10 associated with elevated ALT and AST.
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Nature Portfolio
2021
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oai:doaj.org-article:f13505aebcc04860b9176de8ff12e4682021-12-02T18:47:10ZGWAS of serum ALT and AST reveals an association of SLC30A10 Thr95Ile with hypermanganesemia symptoms10.1038/s41467-021-24563-12041-1723https://doaj.org/article/f13505aebcc04860b9176de8ff12e4682021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24563-1https://doaj.org/toc/2041-1723Circulating liver enzymes, like alanine aminotransferase (ALT) and aspartate aminotransferase (AST), are highly heritable and predictive of disease. Here, the authors perform a genome-wide association study on ALT and AST, revealing a rare variant in SLC30A10 associated with elevated ALT and AST.Lucas D. WardHo-Chou TuChelsea B. QuennevilleShira TsourAlexander O. Flynn-CarrollMargaret M. ParkerAimee M. DeatonPatrick A. J. HaslettLuca A. LottaNiek VerweijManuel A. R. FerreiraRegeneron Genetics CenterGeisinger-Regeneron DiscovEHR CollaborationAris BarasGregory HinklePaul NioiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021) |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Lucas D. Ward Ho-Chou Tu Chelsea B. Quenneville Shira Tsour Alexander O. Flynn-Carroll Margaret M. Parker Aimee M. Deaton Patrick A. J. Haslett Luca A. Lotta Niek Verweij Manuel A. R. Ferreira Regeneron Genetics Center Geisinger-Regeneron DiscovEHR Collaboration Aris Baras Gregory Hinkle Paul Nioi GWAS of serum ALT and AST reveals an association of SLC30A10 Thr95Ile with hypermanganesemia symptoms |
| description |
Circulating liver enzymes, like alanine aminotransferase (ALT) and aspartate aminotransferase (AST), are highly heritable and predictive of disease. Here, the authors perform a genome-wide association study on ALT and AST, revealing a rare variant in SLC30A10 associated with elevated ALT and AST. |
| format |
article |
| author |
Lucas D. Ward Ho-Chou Tu Chelsea B. Quenneville Shira Tsour Alexander O. Flynn-Carroll Margaret M. Parker Aimee M. Deaton Patrick A. J. Haslett Luca A. Lotta Niek Verweij Manuel A. R. Ferreira Regeneron Genetics Center Geisinger-Regeneron DiscovEHR Collaboration Aris Baras Gregory Hinkle Paul Nioi |
| author_facet |
Lucas D. Ward Ho-Chou Tu Chelsea B. Quenneville Shira Tsour Alexander O. Flynn-Carroll Margaret M. Parker Aimee M. Deaton Patrick A. J. Haslett Luca A. Lotta Niek Verweij Manuel A. R. Ferreira Regeneron Genetics Center Geisinger-Regeneron DiscovEHR Collaboration Aris Baras Gregory Hinkle Paul Nioi |
| author_sort |
Lucas D. Ward |
| title |
GWAS of serum ALT and AST reveals an association of SLC30A10 Thr95Ile with hypermanganesemia symptoms |
| title_short |
GWAS of serum ALT and AST reveals an association of SLC30A10 Thr95Ile with hypermanganesemia symptoms |
| title_full |
GWAS of serum ALT and AST reveals an association of SLC30A10 Thr95Ile with hypermanganesemia symptoms |
| title_fullStr |
GWAS of serum ALT and AST reveals an association of SLC30A10 Thr95Ile with hypermanganesemia symptoms |
| title_full_unstemmed |
GWAS of serum ALT and AST reveals an association of SLC30A10 Thr95Ile with hypermanganesemia symptoms |
| title_sort |
gwas of serum alt and ast reveals an association of slc30a10 thr95ile with hypermanganesemia symptoms |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/f13505aebcc04860b9176de8ff12e468 |
| work_keys_str_mv |
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