The radioenhancement potential of Schiff base derived copper (II) compounds against lung carcinoma in vitro.

For the last years, copper complexes have been intensively implicated in biomedical research as components of cancer treatment. Herewith, we provide highlights of the synthesis, physical measurements, structural characterization of the newly developed Cu(II) chelates of Schiff Bases, Cu(Picolinyl-L-...

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Autores principales:	Gohar Tsakanova, Ani Stepanyan, Elina Arakelova, Violetta Ayvazyan, Vahan Tonoyan, Arsen Arakelyan, Guido Hildebrandt, Elisabeth Schültke
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f1353d88a70b41c39a10fdd33caca883
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spelling	oai:doaj.org-article:f1353d88a70b41c39a10fdd33caca8832021-12-02T20:10:21ZThe radioenhancement potential of Schiff base derived copper (II) compounds against lung carcinoma in vitro.1932-620310.1371/journal.pone.0253553https://doaj.org/article/f1353d88a70b41c39a10fdd33caca8832021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253553https://doaj.org/toc/1932-6203For the last years, copper complexes have been intensively implicated in biomedical research as components of cancer treatment. Herewith, we provide highlights of the synthesis, physical measurements, structural characterization of the newly developed Cu(II) chelates of Schiff Bases, Cu(Picolinyl-L-Tryptopahanate)2, Cu(Picolinyl-L-Tyrosinate)2, Cu(Isonicotinyl-L-Tyrosinate)2, Cu(Picolinyl-L-Phenylalaninate)2, Cu(Nicotinyl-L-Phenylalaninate)2, Cu(Isonicotinyl-L-Phenylalaninate)2, and their radioenhancement capacity at kV and MV ranges of irradiation of human lung carcinoma epithelial cells in vitro. The methods of cell growth, viability and proliferation were used. All compounds exerted very potent radioenhancer capacities in the irradiated lung carcinoma cells at both kV and MV ranges in a 100 μM concentration. At a concentration of 10 μM, only Cu(Picolinyl-L-Tyrosinate)2, Cu(Isonicotinyl-L-Tyrosinate)2, Cu(Picolinyl-L-Phenylalaninate)2 possessed radioenhancer properties at kV and MV ranges. Cu(Picolinyl-L-Tryptophanate)2 showed radioenhancer properties only at kV range. Cu(Nicotinyl-L-Phenylalaninate)2 and Cu(Isonicotinyl-L-Phenylalaninate)2 showed remarkable radioenhancer activity only at MV range. All compounds acted in dose-dependent manner at both tested energy ranges. These copper (II) compounds, in combination with 1 Gy irradiation at either 120 kV or 6 MV, are more efficient at delaying cell growth of lung cancer cells and at reducing cell viability in vitro than the irradiation administered alone. Thus, we have demonstrated that the studied copper compounds have a good potential for radioenhancement.Gohar TsakanovaAni StepanyanElina ArakelovaVioletta AyvazyanVahan TonoyanArsen ArakelyanGuido HildebrandtElisabeth SchültkePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0253553 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gohar Tsakanova Ani Stepanyan Elina Arakelova Violetta Ayvazyan Vahan Tonoyan Arsen Arakelyan Guido Hildebrandt Elisabeth Schültke The radioenhancement potential of Schiff base derived copper (II) compounds against lung carcinoma in vitro.
description	For the last years, copper complexes have been intensively implicated in biomedical research as components of cancer treatment. Herewith, we provide highlights of the synthesis, physical measurements, structural characterization of the newly developed Cu(II) chelates of Schiff Bases, Cu(Picolinyl-L-Tryptopahanate)2, Cu(Picolinyl-L-Tyrosinate)2, Cu(Isonicotinyl-L-Tyrosinate)2, Cu(Picolinyl-L-Phenylalaninate)2, Cu(Nicotinyl-L-Phenylalaninate)2, Cu(Isonicotinyl-L-Phenylalaninate)2, and their radioenhancement capacity at kV and MV ranges of irradiation of human lung carcinoma epithelial cells in vitro. The methods of cell growth, viability and proliferation were used. All compounds exerted very potent radioenhancer capacities in the irradiated lung carcinoma cells at both kV and MV ranges in a 100 μM concentration. At a concentration of 10 μM, only Cu(Picolinyl-L-Tyrosinate)2, Cu(Isonicotinyl-L-Tyrosinate)2, Cu(Picolinyl-L-Phenylalaninate)2 possessed radioenhancer properties at kV and MV ranges. Cu(Picolinyl-L-Tryptophanate)2 showed radioenhancer properties only at kV range. Cu(Nicotinyl-L-Phenylalaninate)2 and Cu(Isonicotinyl-L-Phenylalaninate)2 showed remarkable radioenhancer activity only at MV range. All compounds acted in dose-dependent manner at both tested energy ranges. These copper (II) compounds, in combination with 1 Gy irradiation at either 120 kV or 6 MV, are more efficient at delaying cell growth of lung cancer cells and at reducing cell viability in vitro than the irradiation administered alone. Thus, we have demonstrated that the studied copper compounds have a good potential for radioenhancement.
format	article
author	Gohar Tsakanova Ani Stepanyan Elina Arakelova Violetta Ayvazyan Vahan Tonoyan Arsen Arakelyan Guido Hildebrandt Elisabeth Schültke
author_facet	Gohar Tsakanova Ani Stepanyan Elina Arakelova Violetta Ayvazyan Vahan Tonoyan Arsen Arakelyan Guido Hildebrandt Elisabeth Schültke
author_sort	Gohar Tsakanova
title	The radioenhancement potential of Schiff base derived copper (II) compounds against lung carcinoma in vitro.
title_short	The radioenhancement potential of Schiff base derived copper (II) compounds against lung carcinoma in vitro.
title_full	The radioenhancement potential of Schiff base derived copper (II) compounds against lung carcinoma in vitro.
title_fullStr	The radioenhancement potential of Schiff base derived copper (II) compounds against lung carcinoma in vitro.
title_full_unstemmed	The radioenhancement potential of Schiff base derived copper (II) compounds against lung carcinoma in vitro.
title_sort	radioenhancement potential of schiff base derived copper (ii) compounds against lung carcinoma in vitro.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/f1353d88a70b41c39a10fdd33caca883
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The radioenhancement potential of Schiff base derived copper (II) compounds against lung carcinoma in vitro.

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