Structural basis for recognition and regulation of arenavirus polymerase L by Z protein

Junin virus (JUNV) causes Argentine hemorrhagic fever and encodes the large protein (L) of the RNA dependent RNA polymerase (RdRp) and its regulator, the matrix zinc-binding protein (Z). Here, the authors present the 3.54 Å cryo-EM structure of the complex of JUNV L with Z, and they propose a model...

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Autores principales:	Huiling Kang, Jingyuan Cong, Chenlong Wang, Wenxin Ji, Yuhui Xin, Ying Qian, Xuemei Li, Yutao Chen, Zihe Rao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f137d9e89a0d4bce9351150077367aaf
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spelling	oai:doaj.org-article:f137d9e89a0d4bce9351150077367aaf2021-12-02T15:23:19ZStructural basis for recognition and regulation of arenavirus polymerase L by Z protein10.1038/s41467-021-24458-12041-1723https://doaj.org/article/f137d9e89a0d4bce9351150077367aaf2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24458-1https://doaj.org/toc/2041-1723Junin virus (JUNV) causes Argentine hemorrhagic fever and encodes the large protein (L) of the RNA dependent RNA polymerase (RdRp) and its regulator, the matrix zinc-binding protein (Z). Here, the authors present the 3.54 Å cryo-EM structure of the complex of JUNV L with Z, and they propose a model of how JUNV L is regulated by Z during the viral life cycle and RNA synthesis.Huiling KangJingyuan CongChenlong WangWenxin JiYuhui XinYing QianXuemei LiYutao ChenZihe RaoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Huiling Kang Jingyuan Cong Chenlong Wang Wenxin Ji Yuhui Xin Ying Qian Xuemei Li Yutao Chen Zihe Rao Structural basis for recognition and regulation of arenavirus polymerase L by Z protein
description	Junin virus (JUNV) causes Argentine hemorrhagic fever and encodes the large protein (L) of the RNA dependent RNA polymerase (RdRp) and its regulator, the matrix zinc-binding protein (Z). Here, the authors present the 3.54 Å cryo-EM structure of the complex of JUNV L with Z, and they propose a model of how JUNV L is regulated by Z during the viral life cycle and RNA synthesis.
format	article
author	Huiling Kang Jingyuan Cong Chenlong Wang Wenxin Ji Yuhui Xin Ying Qian Xuemei Li Yutao Chen Zihe Rao
author_facet	Huiling Kang Jingyuan Cong Chenlong Wang Wenxin Ji Yuhui Xin Ying Qian Xuemei Li Yutao Chen Zihe Rao
author_sort	Huiling Kang
title	Structural basis for recognition and regulation of arenavirus polymerase L by Z protein
title_short	Structural basis for recognition and regulation of arenavirus polymerase L by Z protein
title_full	Structural basis for recognition and regulation of arenavirus polymerase L by Z protein
title_fullStr	Structural basis for recognition and regulation of arenavirus polymerase L by Z protein
title_full_unstemmed	Structural basis for recognition and regulation of arenavirus polymerase L by Z protein
title_sort	structural basis for recognition and regulation of arenavirus polymerase l by z protein
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f137d9e89a0d4bce9351150077367aaf
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Structural basis for recognition and regulation of arenavirus polymerase L by Z protein

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