Dopamine Transporter SPECT Imaging in Corticobasal Syndrome.
<h4>Objective</h4>To investigate dopaminergic function in a large cohort of patients with corticobasal syndrome (CBS) and describe its relationship with clinical features in comparison to Parkinson's disease and healthy control subjects. In addition, we assessed prevalence and featu...
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2011
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oai:doaj.org-article:f13962d81269497b942c45cdf95caf722021-11-18T06:54:34ZDopamine Transporter SPECT Imaging in Corticobasal Syndrome.1932-620310.1371/journal.pone.0018301https://doaj.org/article/f13962d81269497b942c45cdf95caf722011-05-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21559307/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>To investigate dopaminergic function in a large cohort of patients with corticobasal syndrome (CBS) and describe its relationship with clinical features in comparison to Parkinson's disease and healthy control subjects. In addition, we assessed prevalence and features of individuals with CBS and in vivo evidence of preserved nigral neuronal density.<h4>Background</h4>Substantia nigra pars compacta (SNc) neuronal degeneration is a mandatory pathological criterion for definite corticobasal degeneration, though sporadic autopsy-proven cases with ante-mortem imaging evidence of preserved nigral terminals have been recently described.<h4>Methods</h4>In this multicenter study, we investigated presynaptic nigrostriatal function in 36 outpatients fulfilling clinical criteria for "probable corticobasal degeneration" (age 71±7.3 years; disease duration 3.9±1.6 years), 37 PD and 24 healthy control subjects using FP-CIT single photon emission computed tomography. Clinical, neuropsychological, and magnetic resonance imaging assessment was performed to characterize CBS patients. Linear discriminant analysis was used to categorize normal vs. pathological scans.<h4>Results</h4>FP-CIT binding reduction in patients with CBS was characterized by larger variability, more uniform reduction throughout the striatum and greater hemispheric asymmetry compared to PD. Moreover, there was no significant correlation between tracer uptake values and clinical features such as disease duration and severity. Despite all CBS subjects showed obvious bilateral extrapyramidal signs, FP-CIT uptake was found to be normal bilaterally in four CBS patients and only unilaterally in other four cases. Extensive clinical, neuropsychological and imaging assessment did not reveal remarkable differences between CBS subjects with normal vs. pathological FP-CIT uptake.<h4>Conclusions</h4>Our findings support the hypothesis that extrapyramidal motor symptoms in CBS are not invariably associated with SNc neuronal degeneration and that supranigral factors may play a major role in several cases. CBS individuals with normal FP-CIT uptake do not show any clinical or cognitive feature suggesting a different pathology than CBD.Roberto CiliaCarlo RossiDaniela FrosiniDuccio VolterraniChiara SiriCristina PagniRiccardo BentiGianni PezzoliUbaldo BonuccelliAngelo AntoniniRoberto CeravoloPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 5, p e18301 (2011) |
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Medicine R Science Q Roberto Cilia Carlo Rossi Daniela Frosini Duccio Volterrani Chiara Siri Cristina Pagni Riccardo Benti Gianni Pezzoli Ubaldo Bonuccelli Angelo Antonini Roberto Ceravolo Dopamine Transporter SPECT Imaging in Corticobasal Syndrome. |
| description |
<h4>Objective</h4>To investigate dopaminergic function in a large cohort of patients with corticobasal syndrome (CBS) and describe its relationship with clinical features in comparison to Parkinson's disease and healthy control subjects. In addition, we assessed prevalence and features of individuals with CBS and in vivo evidence of preserved nigral neuronal density.<h4>Background</h4>Substantia nigra pars compacta (SNc) neuronal degeneration is a mandatory pathological criterion for definite corticobasal degeneration, though sporadic autopsy-proven cases with ante-mortem imaging evidence of preserved nigral terminals have been recently described.<h4>Methods</h4>In this multicenter study, we investigated presynaptic nigrostriatal function in 36 outpatients fulfilling clinical criteria for "probable corticobasal degeneration" (age 71±7.3 years; disease duration 3.9±1.6 years), 37 PD and 24 healthy control subjects using FP-CIT single photon emission computed tomography. Clinical, neuropsychological, and magnetic resonance imaging assessment was performed to characterize CBS patients. Linear discriminant analysis was used to categorize normal vs. pathological scans.<h4>Results</h4>FP-CIT binding reduction in patients with CBS was characterized by larger variability, more uniform reduction throughout the striatum and greater hemispheric asymmetry compared to PD. Moreover, there was no significant correlation between tracer uptake values and clinical features such as disease duration and severity. Despite all CBS subjects showed obvious bilateral extrapyramidal signs, FP-CIT uptake was found to be normal bilaterally in four CBS patients and only unilaterally in other four cases. Extensive clinical, neuropsychological and imaging assessment did not reveal remarkable differences between CBS subjects with normal vs. pathological FP-CIT uptake.<h4>Conclusions</h4>Our findings support the hypothesis that extrapyramidal motor symptoms in CBS are not invariably associated with SNc neuronal degeneration and that supranigral factors may play a major role in several cases. CBS individuals with normal FP-CIT uptake do not show any clinical or cognitive feature suggesting a different pathology than CBD. |
| format |
article |
| author |
Roberto Cilia Carlo Rossi Daniela Frosini Duccio Volterrani Chiara Siri Cristina Pagni Riccardo Benti Gianni Pezzoli Ubaldo Bonuccelli Angelo Antonini Roberto Ceravolo |
| author_facet |
Roberto Cilia Carlo Rossi Daniela Frosini Duccio Volterrani Chiara Siri Cristina Pagni Riccardo Benti Gianni Pezzoli Ubaldo Bonuccelli Angelo Antonini Roberto Ceravolo |
| author_sort |
Roberto Cilia |
| title |
Dopamine Transporter SPECT Imaging in Corticobasal Syndrome. |
| title_short |
Dopamine Transporter SPECT Imaging in Corticobasal Syndrome. |
| title_full |
Dopamine Transporter SPECT Imaging in Corticobasal Syndrome. |
| title_fullStr |
Dopamine Transporter SPECT Imaging in Corticobasal Syndrome. |
| title_full_unstemmed |
Dopamine Transporter SPECT Imaging in Corticobasal Syndrome. |
| title_sort |
dopamine transporter spect imaging in corticobasal syndrome. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2011 |
| url |
https://doaj.org/article/f13962d81269497b942c45cdf95caf72 |
| work_keys_str_mv |
AT robertocilia dopaminetransporterspectimagingincorticobasalsyndrome AT carlorossi dopaminetransporterspectimagingincorticobasalsyndrome AT danielafrosini dopaminetransporterspectimagingincorticobasalsyndrome AT ducciovolterrani dopaminetransporterspectimagingincorticobasalsyndrome AT chiarasiri dopaminetransporterspectimagingincorticobasalsyndrome AT cristinapagni dopaminetransporterspectimagingincorticobasalsyndrome AT riccardobenti dopaminetransporterspectimagingincorticobasalsyndrome AT giannipezzoli dopaminetransporterspectimagingincorticobasalsyndrome AT ubaldobonuccelli dopaminetransporterspectimagingincorticobasalsyndrome AT angeloantonini dopaminetransporterspectimagingincorticobasalsyndrome AT robertoceravolo dopaminetransporterspectimagingincorticobasalsyndrome |
| _version_ |
1718424265496199168 |