FREQUENCY OF HUMAN LEUKOCYTE ANTIGEN B27(HLA-B27) IN CLINICALLY DIAGNOSED ANKYLOSING SPONDYLITIS; A STUDY OF 100 CASES

Objective: To determine the frequency of Human leukocyte antigen B-27 patients with clinically diagnosed ankylosing spondylitis and frequency of peripheral joints‟ involvement and serum inflammatory markers (raised serum C-reactive protein & erythrocyte sedimentation rate). Study Design: Desc...

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Autores principales:	Sardar Muhammad, Amer Fakhr, Muhammad Adnan Manzar, Farzana Hakim, Taimoor Ashraf Khan, Bilal Ahmad
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2019
Materias:	ankylosing spondylitis axial spondylitis extra articular manifestation human leukocyte antigen b-27 (hla b-27) inflammatory markers peripheral arthritis spondyloarthritis Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f139c44766804d3490cff819a313c00d
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spelling	oai:doaj.org-article:f139c44766804d3490cff819a313c00d2021-11-05T04:22:09ZFREQUENCY OF HUMAN LEUKOCYTE ANTIGEN B27(HLA-B27) IN CLINICALLY DIAGNOSED ANKYLOSING SPONDYLITIS; A STUDY OF 100 CASES0030-96482411-8842https://doaj.org/article/f139c44766804d3490cff819a313c00d2019-12-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/3632/2455https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine the frequency of Human leukocyte antigen B-27 patients with clinically diagnosed ankylosing spondylitis and frequency of peripheral joints‟ involvement and serum inflammatory markers (raised serum C-reactive protein & erythrocyte sedimentation rate). Study Design: Descriptive, cross-sectional study. Place and Duration of Study: Department of Rheumatology Pak Emirates Military Hospital, Rawalpindi for duration of 10 months from Jan 2018 to Oct 2018. Methodology: We included 100 cases of Ankylosing Spondylitis. Sample was selected by consecutive sampling technique and used “(Modified) New York Classification Criteria for Ankylosing Spondylitis”. Blood samples for C-reactive protein & erythrocyte sedimentation rate and Human leukocyte antigen B-27 were analysed by the same pathologist. We analyzed the data by using SPSS version 20. Results: Mean age of cases was 25 ± 4.5 years. Seventy-seven patients were positive for Human leukocyte antigen B27 and 23 were negative. In 69% patients erythrocyte sedimentation rate was high and in 64% patients C-reactive protein was raised. In 33% patient there was only axial involvement while peripheral arthritis was present in 67% of patients and enthesitis in 60%. Only 5% patients have the uveitis (All positive for Human leukocyte antigen B-27). Only one patient had cardiac involvement. Conclusion: Ankylosing Spondylitis was found a common disease and study results showed similar trends of positive Human leukocyte antigen B-27 cases as in the rest of the world. Human leukocyte antigen B-27 has a strong statistically significant association with peripheral joint involvement and acute anterior uveitis.Sardar MuhammadAmer FakhrMuhammad Adnan ManzarFarzana HakimTaimoor Ashraf KhanBilal AhmadArmy Medical College Rawalpindiarticleankylosing spondylitisaxial spondylitisextra articular manifestationhuman leukocyte antigen b-27 (hla b-27)inflammatory markersperipheral arthritisspondyloarthritisMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 69, Iss 6, Pp 1194-1198 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	ankylosing spondylitis axial spondylitis extra articular manifestation human leukocyte antigen b-27 (hla b-27) inflammatory markers peripheral arthritis spondyloarthritis Medicine R Medicine (General) R5-920
spellingShingle	ankylosing spondylitis axial spondylitis extra articular manifestation human leukocyte antigen b-27 (hla b-27) inflammatory markers peripheral arthritis spondyloarthritis Medicine R Medicine (General) R5-920 Sardar Muhammad Amer Fakhr Muhammad Adnan Manzar Farzana Hakim Taimoor Ashraf Khan Bilal Ahmad FREQUENCY OF HUMAN LEUKOCYTE ANTIGEN B27(HLA-B27) IN CLINICALLY DIAGNOSED ANKYLOSING SPONDYLITIS; A STUDY OF 100 CASES
description	Objective: To determine the frequency of Human leukocyte antigen B-27 patients with clinically diagnosed ankylosing spondylitis and frequency of peripheral joints‟ involvement and serum inflammatory markers (raised serum C-reactive protein & erythrocyte sedimentation rate). Study Design: Descriptive, cross-sectional study. Place and Duration of Study: Department of Rheumatology Pak Emirates Military Hospital, Rawalpindi for duration of 10 months from Jan 2018 to Oct 2018. Methodology: We included 100 cases of Ankylosing Spondylitis. Sample was selected by consecutive sampling technique and used “(Modified) New York Classification Criteria for Ankylosing Spondylitis”. Blood samples for C-reactive protein & erythrocyte sedimentation rate and Human leukocyte antigen B-27 were analysed by the same pathologist. We analyzed the data by using SPSS version 20. Results: Mean age of cases was 25 ± 4.5 years. Seventy-seven patients were positive for Human leukocyte antigen B27 and 23 were negative. In 69% patients erythrocyte sedimentation rate was high and in 64% patients C-reactive protein was raised. In 33% patient there was only axial involvement while peripheral arthritis was present in 67% of patients and enthesitis in 60%. Only 5% patients have the uveitis (All positive for Human leukocyte antigen B-27). Only one patient had cardiac involvement. Conclusion: Ankylosing Spondylitis was found a common disease and study results showed similar trends of positive Human leukocyte antigen B-27 cases as in the rest of the world. Human leukocyte antigen B-27 has a strong statistically significant association with peripheral joint involvement and acute anterior uveitis.
format	article
author	Sardar Muhammad Amer Fakhr Muhammad Adnan Manzar Farzana Hakim Taimoor Ashraf Khan Bilal Ahmad
author_facet	Sardar Muhammad Amer Fakhr Muhammad Adnan Manzar Farzana Hakim Taimoor Ashraf Khan Bilal Ahmad
author_sort	Sardar Muhammad
title	FREQUENCY OF HUMAN LEUKOCYTE ANTIGEN B27(HLA-B27) IN CLINICALLY DIAGNOSED ANKYLOSING SPONDYLITIS; A STUDY OF 100 CASES
title_short	FREQUENCY OF HUMAN LEUKOCYTE ANTIGEN B27(HLA-B27) IN CLINICALLY DIAGNOSED ANKYLOSING SPONDYLITIS; A STUDY OF 100 CASES
title_full	FREQUENCY OF HUMAN LEUKOCYTE ANTIGEN B27(HLA-B27) IN CLINICALLY DIAGNOSED ANKYLOSING SPONDYLITIS; A STUDY OF 100 CASES
title_fullStr	FREQUENCY OF HUMAN LEUKOCYTE ANTIGEN B27(HLA-B27) IN CLINICALLY DIAGNOSED ANKYLOSING SPONDYLITIS; A STUDY OF 100 CASES
title_full_unstemmed	FREQUENCY OF HUMAN LEUKOCYTE ANTIGEN B27(HLA-B27) IN CLINICALLY DIAGNOSED ANKYLOSING SPONDYLITIS; A STUDY OF 100 CASES
title_sort	frequency of human leukocyte antigen b27(hla-b27) in clinically diagnosed ankylosing spondylitis; a study of 100 cases
publisher	Army Medical College Rawalpindi
publishDate	2019
url	https://doaj.org/article/f139c44766804d3490cff819a313c00d
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FREQUENCY OF HUMAN LEUKOCYTE ANTIGEN B27(HLA-B27) IN CLINICALLY DIAGNOSED ANKYLOSING SPONDYLITIS; A STUDY OF 100 CASES

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