A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units

Polyketides are typically assembled from a starter unit and malonyl- and/or methylmalonyl-CoA-derived extender units, but the macrolide antibiotics stambomycins incorporate non-standard alkylmalonyl-CoA extender units. Here, the authors describe the biosynthetic pathway responsible for this unusual...

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Autores principales:	Lauren Ray, Timothy R. Valentic, Takeshi Miyazawa, David M. Withall, Lijiang Song, Jacob C. Milligan, Hiroyuki Osada, Shunji Takahashi, Shiou-Chuan Tsai, Gregory L. Challis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f13d3b5a30894fbfb9a232d6e4194380
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spelling	oai:doaj.org-article:f13d3b5a30894fbfb9a232d6e41943802021-12-02T15:34:11ZA crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units10.1038/ncomms136092041-1723https://doaj.org/article/f13d3b5a30894fbfb9a232d6e41943802016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13609https://doaj.org/toc/2041-1723Polyketides are typically assembled from a starter unit and malonyl- and/or methylmalonyl-CoA-derived extender units, but the macrolide antibiotics stambomycins incorporate non-standard alkylmalonyl-CoA extender units. Here, the authors describe the biosynthetic pathway responsible for this unusual synthesis.Lauren RayTimothy R. ValenticTakeshi MiyazawaDavid M. WithallLijiang SongJacob C. MilliganHiroyuki OsadaShunji TakahashiShiou-Chuan TsaiGregory L. ChallisNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lauren Ray Timothy R. Valentic Takeshi Miyazawa David M. Withall Lijiang Song Jacob C. Milligan Hiroyuki Osada Shunji Takahashi Shiou-Chuan Tsai Gregory L. Challis A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units
description	Polyketides are typically assembled from a starter unit and malonyl- and/or methylmalonyl-CoA-derived extender units, but the macrolide antibiotics stambomycins incorporate non-standard alkylmalonyl-CoA extender units. Here, the authors describe the biosynthetic pathway responsible for this unusual synthesis.
format	article
author	Lauren Ray Timothy R. Valentic Takeshi Miyazawa David M. Withall Lijiang Song Jacob C. Milligan Hiroyuki Osada Shunji Takahashi Shiou-Chuan Tsai Gregory L. Challis
author_facet	Lauren Ray Timothy R. Valentic Takeshi Miyazawa David M. Withall Lijiang Song Jacob C. Milligan Hiroyuki Osada Shunji Takahashi Shiou-Chuan Tsai Gregory L. Challis
author_sort	Lauren Ray
title	A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units
title_short	A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units
title_full	A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units
title_fullStr	A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units
title_full_unstemmed	A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units
title_sort	crotonyl-coa reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-coa polyketide synthase extender units
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/f13d3b5a30894fbfb9a232d6e4194380
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A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units

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