Editorial of Special Issue “Multiple Sclerosis: Diagnosis and Treatment II”

The special issue on Multiple Sclerosis: Diagnosis and Treatment II, reflects advances and discoveries in the molecular and cellular mechanisms of disease, and novel laboratory techniques providing more sensitivity to diagnostic techninques and the understanding of neuroinflammation. Mitochondrial-m...

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Autor principal:	Victor M. Rivera
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	multiple sclerosis acetylcholine PBMCs minority populations spinal cord sphingosine-1-phosphate modulators Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f13e262a3a3c4f5cb9ce136b14313a7a
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spelling	oai:doaj.org-article:f13e262a3a3c4f5cb9ce136b14313a7a2021-11-25T16:49:31ZEditorial of Special Issue “Multiple Sclerosis: Diagnosis and Treatment II”10.3390/biomedicines91116052227-9059https://doaj.org/article/f13e262a3a3c4f5cb9ce136b14313a7a2021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1605https://doaj.org/toc/2227-9059The special issue on Multiple Sclerosis: Diagnosis and Treatment II, reflects advances and discoveries in the molecular and cellular mechanisms of disease, and novel laboratory techniques providing more sensitivity to diagnostic techninques and the understanding of neuroinflammation. Mitochondrial-mediated apoptosis in isolated peripheral blood mononuclear cells and the role of reactive oxygen species are studied as indicators of activity of MS. In these cells, downregulation of circular and linera RNAs are reported as markers of highly active disease in MS. Progress and importance of Neurofilaments determinations in early diagnosis and as a marker of disease activity, and the analysis of the complex mechanisms and therapeutic potential of Sphingosine-1-phosphate receptor modulator are discussed. Epidemiologic observations from a highly diversified area of the world provide more insights into this important aspect of MS; discussions on the clinical challenges posed by spinal cord involvement in demyelinatind disorders and the latest aspects of pediatric onset MS, complement this fine collection of scientific papers.Victor M. RiveraMDPI AGarticlemultiple sclerosisacetylcholinePBMCsminority populationsspinal cordsphingosine-1-phosphate modulatorsBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1605, p 1605 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	multiple sclerosis acetylcholine PBMCs minority populations spinal cord sphingosine-1-phosphate modulators Biology (General) QH301-705.5
spellingShingle	multiple sclerosis acetylcholine PBMCs minority populations spinal cord sphingosine-1-phosphate modulators Biology (General) QH301-705.5 Victor M. Rivera Editorial of Special Issue “Multiple Sclerosis: Diagnosis and Treatment II”
description	The special issue on Multiple Sclerosis: Diagnosis and Treatment II, reflects advances and discoveries in the molecular and cellular mechanisms of disease, and novel laboratory techniques providing more sensitivity to diagnostic techninques and the understanding of neuroinflammation. Mitochondrial-mediated apoptosis in isolated peripheral blood mononuclear cells and the role of reactive oxygen species are studied as indicators of activity of MS. In these cells, downregulation of circular and linera RNAs are reported as markers of highly active disease in MS. Progress and importance of Neurofilaments determinations in early diagnosis and as a marker of disease activity, and the analysis of the complex mechanisms and therapeutic potential of Sphingosine-1-phosphate receptor modulator are discussed. Epidemiologic observations from a highly diversified area of the world provide more insights into this important aspect of MS; discussions on the clinical challenges posed by spinal cord involvement in demyelinatind disorders and the latest aspects of pediatric onset MS, complement this fine collection of scientific papers.
format	article
author	Victor M. Rivera
author_facet	Victor M. Rivera
author_sort	Victor M. Rivera
title	Editorial of Special Issue “Multiple Sclerosis: Diagnosis and Treatment II”
title_short	Editorial of Special Issue “Multiple Sclerosis: Diagnosis and Treatment II”
title_full	Editorial of Special Issue “Multiple Sclerosis: Diagnosis and Treatment II”
title_fullStr	Editorial of Special Issue “Multiple Sclerosis: Diagnosis and Treatment II”
title_full_unstemmed	Editorial of Special Issue “Multiple Sclerosis: Diagnosis and Treatment II”
title_sort	editorial of special issue “multiple sclerosis: diagnosis and treatment ii”
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f13e262a3a3c4f5cb9ce136b14313a7a
work_keys_str_mv	AT victormrivera editorialofspecialissuemultiplesclerosisdiagnosisandtreatmentii
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Editorial of Special Issue “Multiple Sclerosis: Diagnosis and Treatment II”

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