Lipid biomarkers in statin users with coronary artery disease annotated by coronary computed tomography angiography

Abstract Molecular markers are suggested to improve the diagnostic and prognostic accuracy in patients with coronary artery disease (CAD) beyond current clinical scores based on age, gender, symptoms and traditional risk factors. In this context, plasma lipids are emerging as predictors of both plaq...

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Autores principales:	Elena Michelucci, Nicoletta Di Giorgi, Francesco Finamore, Jeff M. Smit, Arthur J. H. A. Scholte, Giovanni Signore, Silvia Rocchiccioli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f13f5c972baf4beaaff2f2f857835146
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spelling	oai:doaj.org-article:f13f5c972baf4beaaff2f2f8578351462021-12-02T17:40:48ZLipid biomarkers in statin users with coronary artery disease annotated by coronary computed tomography angiography10.1038/s41598-021-92339-02045-2322https://doaj.org/article/f13f5c972baf4beaaff2f2f8578351462021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92339-0https://doaj.org/toc/2045-2322Abstract Molecular markers are suggested to improve the diagnostic and prognostic accuracy in patients with coronary artery disease (CAD) beyond current clinical scores based on age, gender, symptoms and traditional risk factors. In this context, plasma lipids are emerging as predictors of both plaque composition and risk of future events. We aim to identify plasma lipid biomarkers associated to CAD indexes of stenosis severity, plaque lipid content and a comprensive score of CAD extent and its risk. We used a simple high performance liquid chromatography-tandem mass spectrometry method to identify 69 plasma lipids in 132 subjects referred to Coronary Computed Tomography Angiography (CCTA) for suspected CAD, all under statin treatment. Patients were stratified in groups using three different CCTA-based annotations: CTA-risk score, lipid plaque prevalence (LPP) ratio and the coronary artery disease-reporting and data system (CAD-RADS). We identified a common set of lipid biomarkers composed of 7 sphingomyelins and 3 phosphatidylethanolamines, which discriminates between high risk CAD patients and controls regardless of the CAD annotations used (CTA score, LPP ratio, or CAD-RADS). These results highlight the potential of circulating lipids as biomarkers of stenosis severity, non calcified plaque composition and overall plaque risk of events.Elena MichelucciNicoletta Di GiorgiFrancesco FinamoreJeff M. SmitArthur J. H. A. ScholteGiovanni SignoreSilvia RocchiccioliNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elena Michelucci Nicoletta Di Giorgi Francesco Finamore Jeff M. Smit Arthur J. H. A. Scholte Giovanni Signore Silvia Rocchiccioli Lipid biomarkers in statin users with coronary artery disease annotated by coronary computed tomography angiography
description	Abstract Molecular markers are suggested to improve the diagnostic and prognostic accuracy in patients with coronary artery disease (CAD) beyond current clinical scores based on age, gender, symptoms and traditional risk factors. In this context, plasma lipids are emerging as predictors of both plaque composition and risk of future events. We aim to identify plasma lipid biomarkers associated to CAD indexes of stenosis severity, plaque lipid content and a comprensive score of CAD extent and its risk. We used a simple high performance liquid chromatography-tandem mass spectrometry method to identify 69 plasma lipids in 132 subjects referred to Coronary Computed Tomography Angiography (CCTA) for suspected CAD, all under statin treatment. Patients were stratified in groups using three different CCTA-based annotations: CTA-risk score, lipid plaque prevalence (LPP) ratio and the coronary artery disease-reporting and data system (CAD-RADS). We identified a common set of lipid biomarkers composed of 7 sphingomyelins and 3 phosphatidylethanolamines, which discriminates between high risk CAD patients and controls regardless of the CAD annotations used (CTA score, LPP ratio, or CAD-RADS). These results highlight the potential of circulating lipids as biomarkers of stenosis severity, non calcified plaque composition and overall plaque risk of events.
format	article
author	Elena Michelucci Nicoletta Di Giorgi Francesco Finamore Jeff M. Smit Arthur J. H. A. Scholte Giovanni Signore Silvia Rocchiccioli
author_facet	Elena Michelucci Nicoletta Di Giorgi Francesco Finamore Jeff M. Smit Arthur J. H. A. Scholte Giovanni Signore Silvia Rocchiccioli
author_sort	Elena Michelucci
title	Lipid biomarkers in statin users with coronary artery disease annotated by coronary computed tomography angiography
title_short	Lipid biomarkers in statin users with coronary artery disease annotated by coronary computed tomography angiography
title_full	Lipid biomarkers in statin users with coronary artery disease annotated by coronary computed tomography angiography
title_fullStr	Lipid biomarkers in statin users with coronary artery disease annotated by coronary computed tomography angiography
title_full_unstemmed	Lipid biomarkers in statin users with coronary artery disease annotated by coronary computed tomography angiography
title_sort	lipid biomarkers in statin users with coronary artery disease annotated by coronary computed tomography angiography
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f13f5c972baf4beaaff2f2f857835146
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Lipid biomarkers in statin users with coronary artery disease annotated by coronary computed tomography angiography

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