Associations of FKBP5 polymorphisms and methylation and parenting style with depressive symptoms among Chinese adolescents

Abstract Background Genetic factors may interplay with environmental stressors to contribute to risks of depressive symptoms. This study aimed to investigate the association of FKBP5 polymorphisms and DNA methylation with depressive symptoms among Chinese adolescents, considering the role of parenti...

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Autores principales:	Lan Guo, Wanxin Wang, Yangfeng Guo, Xueying Du, Guangduoji Shi, Ciyong Lu
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	FKBP5 polymorphism and methylation Parenting style Depressive symptoms Chinese adolescents Nested case-control study Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/f1418aaed45a47199ab794b8272c7b78
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spelling	oai:doaj.org-article:f1418aaed45a47199ab794b8272c7b782021-11-14T12:08:31ZAssociations of FKBP5 polymorphisms and methylation and parenting style with depressive symptoms among Chinese adolescents10.1186/s12888-021-03576-61471-244Xhttps://doaj.org/article/f1418aaed45a47199ab794b8272c7b782021-11-01T00:00:00Zhttps://doi.org/10.1186/s12888-021-03576-6https://doaj.org/toc/1471-244XAbstract Background Genetic factors may interplay with environmental stressors to contribute to risks of depressive symptoms. This study aimed to investigate the association of FKBP5 polymorphisms and DNA methylation with depressive symptoms among Chinese adolescents, considering the role of parenting style. Methods This study used a nested case-control study design based on a cohort study, and the case (n = 120) and control groups (n = 118) were matched with age. Depressive symptoms, parenting style, and other demographics were measured. Fourteen potential polymorphisms and one promoter region in the FKBP5 gene were selected for genotyping and methylation analysis. Results In the adjusted models, a significant association between FKBP5 rs7757037 and depressive symptoms was found in the codominant model (AG vs. GG; adjusted odds ratio [AOR] = 2.56, 95% CI = 1.13–5.78) and dominant model (AA+AG vs. GG; AOR = 2.38, 95% CI = 1.11–5.120); rs2817032 and rs2817035 polymorphisms were associated with depressive symptoms in the codominant model and dominant model. Significant interactions between rs7757037 and the father’s parenting style were found in the codominant model (P = 0.043) and dominant model (P = 0.043), but the gene-environment interactions were not significant after correcting for multiple testing. Moreover, the significant main effects of FKBP5 methylation status on depressive symptoms were not observed, and there was no significant interaction between FKBP5 methylation status and parenting style on depressive symptoms. Conclusions Further studies are required to confirm the effect of FKBP5 polymorphisms and methylation as well as their interactions with parenting styles in larger samples.Lan GuoWanxin WangYangfeng GuoXueying DuGuangduoji ShiCiyong LuBMCarticleFKBP5 polymorphism and methylationParenting styleDepressive symptomsChinese adolescentsNested case-control studyPsychiatryRC435-571ENBMC Psychiatry, Vol 21, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	FKBP5 polymorphism and methylation Parenting style Depressive symptoms Chinese adolescents Nested case-control study Psychiatry RC435-571
spellingShingle	FKBP5 polymorphism and methylation Parenting style Depressive symptoms Chinese adolescents Nested case-control study Psychiatry RC435-571 Lan Guo Wanxin Wang Yangfeng Guo Xueying Du Guangduoji Shi Ciyong Lu Associations of FKBP5 polymorphisms and methylation and parenting style with depressive symptoms among Chinese adolescents
description	Abstract Background Genetic factors may interplay with environmental stressors to contribute to risks of depressive symptoms. This study aimed to investigate the association of FKBP5 polymorphisms and DNA methylation with depressive symptoms among Chinese adolescents, considering the role of parenting style. Methods This study used a nested case-control study design based on a cohort study, and the case (n = 120) and control groups (n = 118) were matched with age. Depressive symptoms, parenting style, and other demographics were measured. Fourteen potential polymorphisms and one promoter region in the FKBP5 gene were selected for genotyping and methylation analysis. Results In the adjusted models, a significant association between FKBP5 rs7757037 and depressive symptoms was found in the codominant model (AG vs. GG; adjusted odds ratio [AOR] = 2.56, 95% CI = 1.13–5.78) and dominant model (AA+AG vs. GG; AOR = 2.38, 95% CI = 1.11–5.120); rs2817032 and rs2817035 polymorphisms were associated with depressive symptoms in the codominant model and dominant model. Significant interactions between rs7757037 and the father’s parenting style were found in the codominant model (P = 0.043) and dominant model (P = 0.043), but the gene-environment interactions were not significant after correcting for multiple testing. Moreover, the significant main effects of FKBP5 methylation status on depressive symptoms were not observed, and there was no significant interaction between FKBP5 methylation status and parenting style on depressive symptoms. Conclusions Further studies are required to confirm the effect of FKBP5 polymorphisms and methylation as well as their interactions with parenting styles in larger samples.
format	article
author	Lan Guo Wanxin Wang Yangfeng Guo Xueying Du Guangduoji Shi Ciyong Lu
author_facet	Lan Guo Wanxin Wang Yangfeng Guo Xueying Du Guangduoji Shi Ciyong Lu
author_sort	Lan Guo
title	Associations of FKBP5 polymorphisms and methylation and parenting style with depressive symptoms among Chinese adolescents
title_short	Associations of FKBP5 polymorphisms and methylation and parenting style with depressive symptoms among Chinese adolescents
title_full	Associations of FKBP5 polymorphisms and methylation and parenting style with depressive symptoms among Chinese adolescents
title_fullStr	Associations of FKBP5 polymorphisms and methylation and parenting style with depressive symptoms among Chinese adolescents
title_full_unstemmed	Associations of FKBP5 polymorphisms and methylation and parenting style with depressive symptoms among Chinese adolescents
title_sort	associations of fkbp5 polymorphisms and methylation and parenting style with depressive symptoms among chinese adolescents
publisher	BMC
publishDate	2021
url	https://doaj.org/article/f1418aaed45a47199ab794b8272c7b78
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Associations of FKBP5 polymorphisms and methylation and parenting style with depressive symptoms among Chinese adolescents

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