Risk Management Assessments of Anti-tuberculosis Adverse Drug Reaction: A Systematic Review

To improve adherence to treatment, quality of life of patients on anti-tuberculosis drugs, and prevent antibiotic resistance, we conducted this systematic review to support risk minimization actions. Methods: Medline, Scopus, and Web of Science were searched with a focus on adverse drug reactions. T...

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Autores principales:	Traore Boubacar, Tsoumbou Bakana Gladys, Nani Samira, Hassoune Samira
Formato:	article
Lenguaje:	EN FR
Publicado:	EDP Sciences 2021
Materias:	Environmental sciences GE1-350
Acceso en línea:	https://doaj.org/article/f141a8c4a3e443a2b0e1fe648137439a
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spelling	oai:doaj.org-article:f141a8c4a3e443a2b0e1fe648137439a2021-11-12T11:44:08ZRisk Management Assessments of Anti-tuberculosis Adverse Drug Reaction: A Systematic Review2267-124210.1051/e3sconf/202131901042https://doaj.org/article/f141a8c4a3e443a2b0e1fe648137439a2021-01-01T00:00:00Zhttps://www.e3s-conferences.org/articles/e3sconf/pdf/2021/95/e3sconf_vigisan_01042.pdfhttps://doaj.org/toc/2267-1242To improve adherence to treatment, quality of life of patients on anti-tuberculosis drugs, and prevent antibiotic resistance, we conducted this systematic review to support risk minimization actions. Methods: Medline, Scopus, and Web of Science were searched with a focus on adverse drug reactions. Two independent reviewers assessed the methodological quality of the included studies using criteria defined by the Newcastle Ottawa Scale. Results: Seven studies were included, and four risk management strategies were identified (psychological intervention, drug dose reduction with or without prescription of adjunctive drugs, drug switching, permanent or temporary drug discontinuation). The strategies adopted were dependent on the nature and severity of the adverse events. All drugs responsible for serious adverse effects were changed or discontinued. Conclusions: The results highlight the relatively low frequency of adverse events leading to permanent discontinuation of 1st-line anti-tuberculosis drugs, but also emphasize the high incidence of adverse events leading to permanent discontinuation of cycloserine.Traore BoubacarTsoumbou Bakana GladysNani SamiraHassoune SamiraEDP SciencesarticleEnvironmental sciencesGE1-350ENFRE3S Web of Conferences, Vol 319, p 01042 (2021)
institution	DOAJ
collection	DOAJ
language	EN FR
topic	Environmental sciences GE1-350
spellingShingle	Environmental sciences GE1-350 Traore Boubacar Tsoumbou Bakana Gladys Nani Samira Hassoune Samira Risk Management Assessments of Anti-tuberculosis Adverse Drug Reaction: A Systematic Review
description	To improve adherence to treatment, quality of life of patients on anti-tuberculosis drugs, and prevent antibiotic resistance, we conducted this systematic review to support risk minimization actions. Methods: Medline, Scopus, and Web of Science were searched with a focus on adverse drug reactions. Two independent reviewers assessed the methodological quality of the included studies using criteria defined by the Newcastle Ottawa Scale. Results: Seven studies were included, and four risk management strategies were identified (psychological intervention, drug dose reduction with or without prescription of adjunctive drugs, drug switching, permanent or temporary drug discontinuation). The strategies adopted were dependent on the nature and severity of the adverse events. All drugs responsible for serious adverse effects were changed or discontinued. Conclusions: The results highlight the relatively low frequency of adverse events leading to permanent discontinuation of 1st-line anti-tuberculosis drugs, but also emphasize the high incidence of adverse events leading to permanent discontinuation of cycloserine.
format	article
author	Traore Boubacar Tsoumbou Bakana Gladys Nani Samira Hassoune Samira
author_facet	Traore Boubacar Tsoumbou Bakana Gladys Nani Samira Hassoune Samira
author_sort	Traore Boubacar
title	Risk Management Assessments of Anti-tuberculosis Adverse Drug Reaction: A Systematic Review
title_short	Risk Management Assessments of Anti-tuberculosis Adverse Drug Reaction: A Systematic Review
title_full	Risk Management Assessments of Anti-tuberculosis Adverse Drug Reaction: A Systematic Review
title_fullStr	Risk Management Assessments of Anti-tuberculosis Adverse Drug Reaction: A Systematic Review
title_full_unstemmed	Risk Management Assessments of Anti-tuberculosis Adverse Drug Reaction: A Systematic Review
title_sort	risk management assessments of anti-tuberculosis adverse drug reaction: a systematic review
publisher	EDP Sciences
publishDate	2021
url	https://doaj.org/article/f141a8c4a3e443a2b0e1fe648137439a
work_keys_str_mv	AT traoreboubacar riskmanagementassessmentsofantituberculosisadversedrugreactionasystematicreview AT tsoumboubakanagladys riskmanagementassessmentsofantituberculosisadversedrugreactionasystematicreview AT nanisamira riskmanagementassessmentsofantituberculosisadversedrugreactionasystematicreview AT hassounesamira riskmanagementassessmentsofantituberculosisadversedrugreactionasystematicreview
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Risk Management Assessments of Anti-tuberculosis Adverse Drug Reaction: A Systematic Review

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