Associations of COVID-19 lockdown with gestational length and preterm birth in China
Abstract Background The effects of COVID-19 lockdown measures on maternal and fetal health remain unclear. We examined the associations of COVID-19 lockdown with gestational length and preterm birth (PTB) in a Chinese population. Methods We obtained medical records of 595,396 singleton live infants...
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2021
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oai:doaj.org-article:f142f68d3b5046a5919c44047861ad392021-11-28T12:29:48ZAssociations of COVID-19 lockdown with gestational length and preterm birth in China10.1186/s12884-021-04268-51471-2393https://doaj.org/article/f142f68d3b5046a5919c44047861ad392021-11-01T00:00:00Zhttps://doi.org/10.1186/s12884-021-04268-5https://doaj.org/toc/1471-2393Abstract Background The effects of COVID-19 lockdown measures on maternal and fetal health remain unclear. We examined the associations of COVID-19 lockdown with gestational length and preterm birth (PTB) in a Chinese population. Methods We obtained medical records of 595,396 singleton live infants born between 2015 and 2020 in 5 cities in Guangdong Province, South China. The exposed group (N = 101,900) included women who experienced the COVID-19 Level I lockdown (1/23–2/24/2020) during pregnancy, while the unexposed group (N = 493,496) included women who were pregnant during the same calendar months in 2015–2019. Cumulative exposure was calculated based on days exposed to different levels of emergency responses with different weighting. Generalized linear regression models were applied to estimate the associations of lockdown exposure with gestational length and risk of PTB (< 37 weeks). Results The exposed group had a shorter mean gestational length than the unexposed group (38.66 vs 38.74 weeks: adjusted β = − 0.06 week [95%CI, − 0.07, − 0.05 week]). The exposed group also had a higher risk of PTB (5.7% vs 5.3%; adjusted OR = 1.08 [95%CI, 1.05, 1.11]). These associations seemed to be stronger when exposure occurred before or during the 23rd gestational week (GW) than during or after the 24th GW. Similarly, higher cumulative lockdown exposure was associated with a shorter gestational length and a higher risk of PTB. Conclusions The COVID-19 lockdown measures were associated with a slightly shorter gestational length and a moderately higher risk of PTB. Early and middle pregnancy periods may be a more susceptible exposure window.Moran DongRui QianJiaqi WangJingjie FanYufeng YeHe ZhouBrian WinEve ReidSuijin ZhengYanyun LvYudong PuHanwei ChenJuan JinQingmei LinXiaoyang LuoGuimin ChenYumeng ChenZhongrong HeGuanhao HeShouzhen ChengJianxiong HuJianpeng XiaoWenjun MaTao LiuXiaozhong WenBMCarticleCOVID-19LockdownGestational lengthPretermChinaGynecology and obstetricsRG1-991ENBMC Pregnancy and Childbirth, Vol 21, Iss 1, Pp 1-14 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
COVID-19 Lockdown Gestational length Preterm China Gynecology and obstetrics RG1-991 |
| spellingShingle |
COVID-19 Lockdown Gestational length Preterm China Gynecology and obstetrics RG1-991 Moran Dong Rui Qian Jiaqi Wang Jingjie Fan Yufeng Ye He Zhou Brian Win Eve Reid Suijin Zheng Yanyun Lv Yudong Pu Hanwei Chen Juan Jin Qingmei Lin Xiaoyang Luo Guimin Chen Yumeng Chen Zhongrong He Guanhao He Shouzhen Cheng Jianxiong Hu Jianpeng Xiao Wenjun Ma Tao Liu Xiaozhong Wen Associations of COVID-19 lockdown with gestational length and preterm birth in China |
| description |
Abstract Background The effects of COVID-19 lockdown measures on maternal and fetal health remain unclear. We examined the associations of COVID-19 lockdown with gestational length and preterm birth (PTB) in a Chinese population. Methods We obtained medical records of 595,396 singleton live infants born between 2015 and 2020 in 5 cities in Guangdong Province, South China. The exposed group (N = 101,900) included women who experienced the COVID-19 Level I lockdown (1/23–2/24/2020) during pregnancy, while the unexposed group (N = 493,496) included women who were pregnant during the same calendar months in 2015–2019. Cumulative exposure was calculated based on days exposed to different levels of emergency responses with different weighting. Generalized linear regression models were applied to estimate the associations of lockdown exposure with gestational length and risk of PTB (< 37 weeks). Results The exposed group had a shorter mean gestational length than the unexposed group (38.66 vs 38.74 weeks: adjusted β = − 0.06 week [95%CI, − 0.07, − 0.05 week]). The exposed group also had a higher risk of PTB (5.7% vs 5.3%; adjusted OR = 1.08 [95%CI, 1.05, 1.11]). These associations seemed to be stronger when exposure occurred before or during the 23rd gestational week (GW) than during or after the 24th GW. Similarly, higher cumulative lockdown exposure was associated with a shorter gestational length and a higher risk of PTB. Conclusions The COVID-19 lockdown measures were associated with a slightly shorter gestational length and a moderately higher risk of PTB. Early and middle pregnancy periods may be a more susceptible exposure window. |
| format |
article |
| author |
Moran Dong Rui Qian Jiaqi Wang Jingjie Fan Yufeng Ye He Zhou Brian Win Eve Reid Suijin Zheng Yanyun Lv Yudong Pu Hanwei Chen Juan Jin Qingmei Lin Xiaoyang Luo Guimin Chen Yumeng Chen Zhongrong He Guanhao He Shouzhen Cheng Jianxiong Hu Jianpeng Xiao Wenjun Ma Tao Liu Xiaozhong Wen |
| author_facet |
Moran Dong Rui Qian Jiaqi Wang Jingjie Fan Yufeng Ye He Zhou Brian Win Eve Reid Suijin Zheng Yanyun Lv Yudong Pu Hanwei Chen Juan Jin Qingmei Lin Xiaoyang Luo Guimin Chen Yumeng Chen Zhongrong He Guanhao He Shouzhen Cheng Jianxiong Hu Jianpeng Xiao Wenjun Ma Tao Liu Xiaozhong Wen |
| author_sort |
Moran Dong |
| title |
Associations of COVID-19 lockdown with gestational length and preterm birth in China |
| title_short |
Associations of COVID-19 lockdown with gestational length and preterm birth in China |
| title_full |
Associations of COVID-19 lockdown with gestational length and preterm birth in China |
| title_fullStr |
Associations of COVID-19 lockdown with gestational length and preterm birth in China |
| title_full_unstemmed |
Associations of COVID-19 lockdown with gestational length and preterm birth in China |
| title_sort |
associations of covid-19 lockdown with gestational length and preterm birth in china |
| publisher |
BMC |
| publishDate |
2021 |
| url |
https://doaj.org/article/f142f68d3b5046a5919c44047861ad39 |
| work_keys_str_mv |
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