Nationwide Hospital-Based Seroprevalence of Hepatitis A and Hepatitis E Virus in Bangladesh

Background: Hepatitis A virus (HAV) and hepatitis E virus (HEV) are transmitted by the fecal-oral route and are responsible for epidemic and sporadic outbreaks of acute hepatitis in low-income countries like Bangladesh. Objective: The purpose of this study was to describe the seroprevalence of acute...

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Autores principales:	Ashraful Islam Khan, M Salimuzzaman, Md. Taufiqul Islam, Mokibul Hassan Afrad, Tahmina Shirin, Monjur Hossain Khan Jony, Md. Ashraful Alam, Mahmudur Rahman, Meerjady Sabrina Flora, Firdausi Qadri
Formato:	article
Lenguaje:	EN
Publicado:	Ubiquity Press 2020
Materias:	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/f1485aaf2c89429786b982f868fc8230
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spelling	oai:doaj.org-article:f1485aaf2c89429786b982f868fc82302021-12-02T09:33:18ZNationwide Hospital-Based Seroprevalence of Hepatitis A and Hepatitis E Virus in Bangladesh2214-999610.5334/aogh.2574https://doaj.org/article/f1485aaf2c89429786b982f868fc82302020-03-01T00:00:00Zhttps://annalsofglobalhealth.org/articles/2574https://doaj.org/toc/2214-9996Background: Hepatitis A virus (HAV) and hepatitis E virus (HEV) are transmitted by the fecal-oral route and are responsible for epidemic and sporadic outbreaks of acute hepatitis in low-income countries like Bangladesh. Objective: The purpose of this study was to describe the seroprevalence of acute hepatitis due to HAV and HEV infection in Bangladesh. Methods: The nationwide food-borne illness surveillance started in 2014 at 10 different hospitals which covered seven divisions of Bangladesh. Blood samples were collected from suspected acute hepatitis cases and screened for the anti-HAV IgM and anti-HEV IgM using enzyme-linked immunosorbent assay (ELISA). Participants’ socioeconomic status, clinical, sanitation and food history were recorded. Multivariate logistic regression was performed to determine the risk factors associated with HAV and HEV infection. Findings: A total of 998 patients were enrolled and tested for both HAV and HEV. Among these, 19% (191/998) were identified as HAV positive and 10% (103/998) were HEV positive. The median age was 12 years and 25 years for HAV and HEV positive patients, respectively. The prevalence of HAV was higher among the females (24.9%), whereas HEV was higher among males (11.2%). The highest occurrence of HAV was observed among children while HEV was most prevalent in the 15–60 years age group (12.4%). Conclusion: Through our nationwide surveillance, it is evident that hepatitis A and hepatitis E infection is common in Bangladesh. These data will be useful towards planning preventive and control measures by strengthening the sanitation programs and vaccination strategies in Bangladesh.Ashraful Islam KhanM SalimuzzamanMd. Taufiqul IslamMokibul Hassan AfradTahmina ShirinMonjur Hossain Khan JonyMd. Ashraful AlamMahmudur RahmanMeerjady Sabrina FloraFirdausi QadriUbiquity PressarticleInfectious and parasitic diseasesRC109-216Public aspects of medicineRA1-1270ENAnnals of Global Health, Vol 86, Iss 1 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
spellingShingle	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270 Ashraful Islam Khan M Salimuzzaman Md. Taufiqul Islam Mokibul Hassan Afrad Tahmina Shirin Monjur Hossain Khan Jony Md. Ashraful Alam Mahmudur Rahman Meerjady Sabrina Flora Firdausi Qadri Nationwide Hospital-Based Seroprevalence of Hepatitis A and Hepatitis E Virus in Bangladesh
description	Background: Hepatitis A virus (HAV) and hepatitis E virus (HEV) are transmitted by the fecal-oral route and are responsible for epidemic and sporadic outbreaks of acute hepatitis in low-income countries like Bangladesh. Objective: The purpose of this study was to describe the seroprevalence of acute hepatitis due to HAV and HEV infection in Bangladesh. Methods: The nationwide food-borne illness surveillance started in 2014 at 10 different hospitals which covered seven divisions of Bangladesh. Blood samples were collected from suspected acute hepatitis cases and screened for the anti-HAV IgM and anti-HEV IgM using enzyme-linked immunosorbent assay (ELISA). Participants’ socioeconomic status, clinical, sanitation and food history were recorded. Multivariate logistic regression was performed to determine the risk factors associated with HAV and HEV infection. Findings: A total of 998 patients were enrolled and tested for both HAV and HEV. Among these, 19% (191/998) were identified as HAV positive and 10% (103/998) were HEV positive. The median age was 12 years and 25 years for HAV and HEV positive patients, respectively. The prevalence of HAV was higher among the females (24.9%), whereas HEV was higher among males (11.2%). The highest occurrence of HAV was observed among children while HEV was most prevalent in the 15–60 years age group (12.4%). Conclusion: Through our nationwide surveillance, it is evident that hepatitis A and hepatitis E infection is common in Bangladesh. These data will be useful towards planning preventive and control measures by strengthening the sanitation programs and vaccination strategies in Bangladesh.
format	article
author	Ashraful Islam Khan M Salimuzzaman Md. Taufiqul Islam Mokibul Hassan Afrad Tahmina Shirin Monjur Hossain Khan Jony Md. Ashraful Alam Mahmudur Rahman Meerjady Sabrina Flora Firdausi Qadri
author_facet	Ashraful Islam Khan M Salimuzzaman Md. Taufiqul Islam Mokibul Hassan Afrad Tahmina Shirin Monjur Hossain Khan Jony Md. Ashraful Alam Mahmudur Rahman Meerjady Sabrina Flora Firdausi Qadri
author_sort	Ashraful Islam Khan
title	Nationwide Hospital-Based Seroprevalence of Hepatitis A and Hepatitis E Virus in Bangladesh
title_short	Nationwide Hospital-Based Seroprevalence of Hepatitis A and Hepatitis E Virus in Bangladesh
title_full	Nationwide Hospital-Based Seroprevalence of Hepatitis A and Hepatitis E Virus in Bangladesh
title_fullStr	Nationwide Hospital-Based Seroprevalence of Hepatitis A and Hepatitis E Virus in Bangladesh
title_full_unstemmed	Nationwide Hospital-Based Seroprevalence of Hepatitis A and Hepatitis E Virus in Bangladesh
title_sort	nationwide hospital-based seroprevalence of hepatitis a and hepatitis e virus in bangladesh
publisher	Ubiquity Press
publishDate	2020
url	https://doaj.org/article/f1485aaf2c89429786b982f868fc8230
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Nationwide Hospital-Based Seroprevalence of Hepatitis A and Hepatitis E Virus in Bangladesh

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