Impacts of body composition parameters and liver cirrhosis on the severity of alcoholic acute pancreatitis.

<h4>Aim</h4>Liver cirrhosis and features of muscle or adipose tissues may affect the severity of acute pancreatitis (AP). We aimed to evaluate the impact of body composition parameters and liver cirrhosis on the severity of AP in patients with alcohol-induced AP (AAP).<h4>Methods&l...

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Autores principales:	Dong Kee Jang, Dong-Won Ahn, Kook Lae Lee, Byeong Gwan Kim, Ji Won Kim, Su Hwan Kim, Hyoun Woo Kang, Dong Seok Lee, Soon Ho Yoon, Sang Joon Park, Ji Bong Jeong
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f14a0516902547bf9166a1c1baa22f71
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spelling	oai:doaj.org-article:f14a0516902547bf9166a1c1baa22f712021-12-02T20:16:16ZImpacts of body composition parameters and liver cirrhosis on the severity of alcoholic acute pancreatitis.1932-620310.1371/journal.pone.0260309https://doaj.org/article/f14a0516902547bf9166a1c1baa22f712021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0260309https://doaj.org/toc/1932-6203<h4>Aim</h4>Liver cirrhosis and features of muscle or adipose tissues may affect the severity of acute pancreatitis (AP). We aimed to evaluate the impact of body composition parameters and liver cirrhosis on the severity of AP in patients with alcohol-induced AP (AAP).<h4>Methods</h4>Patients with presumed AAP who underwent CT within one week after admission were retrospectively enrolled. L3 sectional areas of abdominal fat and muscle, and mean muscle attenuations (MMAs) were quantified. The presence of liver cirrhosis was determined using clinical and CT findings. Factors potentially associated with moderately severe or severe AP were included in the multivariable logistic regression analysis.<h4>Results</h4>A total of 242 patients (47.0 ± 12.6 years, 215 males) with presumed AAP were included. The mild and moderately severe/severe (MSS) groups included 137 (56.6%) and 105 patients (43.4%), respectively. Patients in the MSS group had higher rates of liver cirrhosis, organ failure, and local complications. Among body composition parameters, mean MMA (33.4 vs 36.8 HU, P<0.0001) and abdominal muscle mass (126.5 vs 135.1 cm2, P = 0.029) were significantly lower in the MSS group. The presence of liver cirrhosis (OR, 4.192; 95% CI, 1.620-10.848) was found to be a significant risk factor for moderately severe or severe AP by multivariable analysis.<h4>Conclusion</h4>The results of this study suggest that liver cirrhosis has a significant impact on the severity of AAP. Of the body composition parameters examined, MMA and abdominal muscle mass showed potential as promising predictors.Dong Kee JangDong-Won AhnKook Lae LeeByeong Gwan KimJi Won KimSu Hwan KimHyoun Woo KangDong Seok LeeSoon Ho YoonSang Joon ParkJi Bong JeongPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0260309 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dong Kee Jang Dong-Won Ahn Kook Lae Lee Byeong Gwan Kim Ji Won Kim Su Hwan Kim Hyoun Woo Kang Dong Seok Lee Soon Ho Yoon Sang Joon Park Ji Bong Jeong Impacts of body composition parameters and liver cirrhosis on the severity of alcoholic acute pancreatitis.
description	<h4>Aim</h4>Liver cirrhosis and features of muscle or adipose tissues may affect the severity of acute pancreatitis (AP). We aimed to evaluate the impact of body composition parameters and liver cirrhosis on the severity of AP in patients with alcohol-induced AP (AAP).<h4>Methods</h4>Patients with presumed AAP who underwent CT within one week after admission were retrospectively enrolled. L3 sectional areas of abdominal fat and muscle, and mean muscle attenuations (MMAs) were quantified. The presence of liver cirrhosis was determined using clinical and CT findings. Factors potentially associated with moderately severe or severe AP were included in the multivariable logistic regression analysis.<h4>Results</h4>A total of 242 patients (47.0 ± 12.6 years, 215 males) with presumed AAP were included. The mild and moderately severe/severe (MSS) groups included 137 (56.6%) and 105 patients (43.4%), respectively. Patients in the MSS group had higher rates of liver cirrhosis, organ failure, and local complications. Among body composition parameters, mean MMA (33.4 vs 36.8 HU, P<0.0001) and abdominal muscle mass (126.5 vs 135.1 cm2, P = 0.029) were significantly lower in the MSS group. The presence of liver cirrhosis (OR, 4.192; 95% CI, 1.620-10.848) was found to be a significant risk factor for moderately severe or severe AP by multivariable analysis.<h4>Conclusion</h4>The results of this study suggest that liver cirrhosis has a significant impact on the severity of AAP. Of the body composition parameters examined, MMA and abdominal muscle mass showed potential as promising predictors.
format	article
author	Dong Kee Jang Dong-Won Ahn Kook Lae Lee Byeong Gwan Kim Ji Won Kim Su Hwan Kim Hyoun Woo Kang Dong Seok Lee Soon Ho Yoon Sang Joon Park Ji Bong Jeong
author_facet	Dong Kee Jang Dong-Won Ahn Kook Lae Lee Byeong Gwan Kim Ji Won Kim Su Hwan Kim Hyoun Woo Kang Dong Seok Lee Soon Ho Yoon Sang Joon Park Ji Bong Jeong
author_sort	Dong Kee Jang
title	Impacts of body composition parameters and liver cirrhosis on the severity of alcoholic acute pancreatitis.
title_short	Impacts of body composition parameters and liver cirrhosis on the severity of alcoholic acute pancreatitis.
title_full	Impacts of body composition parameters and liver cirrhosis on the severity of alcoholic acute pancreatitis.
title_fullStr	Impacts of body composition parameters and liver cirrhosis on the severity of alcoholic acute pancreatitis.
title_full_unstemmed	Impacts of body composition parameters and liver cirrhosis on the severity of alcoholic acute pancreatitis.
title_sort	impacts of body composition parameters and liver cirrhosis on the severity of alcoholic acute pancreatitis.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/f14a0516902547bf9166a1c1baa22f71
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Impacts of body composition parameters and liver cirrhosis on the severity of alcoholic acute pancreatitis.

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