Insulin resistance is associated with poor functional outcome after acute ischemic stroke in non-diabetic patients

Abstract Insulin resistance is associated with the occurrence of stroke and atherosclerotic disease. However, the relationship between insulin resistance and the prognosis of acute ischemic stroke in non-diabetic patients is unclear. We hypothesized that insulin resistance might affect short-term fu...

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Autores principales:	Yoonkyung Chang, Chi Kyung Kim, Min-Kyung Kim, Woo‐Keun Seo, Kyungmi Oh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f14aa765648242be8d9c43d64fbbcd89
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spelling	oai:doaj.org-article:f14aa765648242be8d9c43d64fbbcd892021-12-02T15:22:59ZInsulin resistance is associated with poor functional outcome after acute ischemic stroke in non-diabetic patients10.1038/s41598-020-80315-z2045-2322https://doaj.org/article/f14aa765648242be8d9c43d64fbbcd892021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80315-zhttps://doaj.org/toc/2045-2322Abstract Insulin resistance is associated with the occurrence of stroke and atherosclerotic disease. However, the relationship between insulin resistance and the prognosis of acute ischemic stroke in non-diabetic patients is unclear. We hypothesized that insulin resistance might affect short-term functional recovery after acute ischemic stroke in non-diabetic patients. Between May 2014 and December 2016, 1377 consecutive patients with acute ischemic stroke were enrolled from a prospectively maintained stroke registry. After excluding patients with transient ischemic attacks (TIA), pre-stroke disabilities, diabetes mellitus, and patients with incomplete evaluations, 517 patients were included in the study. The homeostasis model assessment of insulin resistance (HOMA-IR) score was used to evaluate the degree of insulin resistance. The patients with the highest quartile of log HOMA-IR index scores were younger and had higher fasting blood glucose, total cholesterol, triglycerides, low-density lipoprotein, and HbA1c levels. Multivariable logistic regression analysis revealed that log HOMA-IR scores were independently associated with poor prognosis after adjusting for age and sex and p < 0.1 in univariable analysis. Insulin resistance was associated with the poor functional outcome of non-diabetic stroke patients. This evidence supports treating insulin resistance in acute ischemic stroke patients with blood glucose levels within the normal range.Yoonkyung ChangChi Kyung KimMin-Kyung KimWoo‐Keun SeoKyungmi OhNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yoonkyung Chang Chi Kyung Kim Min-Kyung Kim Woo‐Keun Seo Kyungmi Oh Insulin resistance is associated with poor functional outcome after acute ischemic stroke in non-diabetic patients
description	Abstract Insulin resistance is associated with the occurrence of stroke and atherosclerotic disease. However, the relationship between insulin resistance and the prognosis of acute ischemic stroke in non-diabetic patients is unclear. We hypothesized that insulin resistance might affect short-term functional recovery after acute ischemic stroke in non-diabetic patients. Between May 2014 and December 2016, 1377 consecutive patients with acute ischemic stroke were enrolled from a prospectively maintained stroke registry. After excluding patients with transient ischemic attacks (TIA), pre-stroke disabilities, diabetes mellitus, and patients with incomplete evaluations, 517 patients were included in the study. The homeostasis model assessment of insulin resistance (HOMA-IR) score was used to evaluate the degree of insulin resistance. The patients with the highest quartile of log HOMA-IR index scores were younger and had higher fasting blood glucose, total cholesterol, triglycerides, low-density lipoprotein, and HbA1c levels. Multivariable logistic regression analysis revealed that log HOMA-IR scores were independently associated with poor prognosis after adjusting for age and sex and p < 0.1 in univariable analysis. Insulin resistance was associated with the poor functional outcome of non-diabetic stroke patients. This evidence supports treating insulin resistance in acute ischemic stroke patients with blood glucose levels within the normal range.
format	article
author	Yoonkyung Chang Chi Kyung Kim Min-Kyung Kim Woo‐Keun Seo Kyungmi Oh
author_facet	Yoonkyung Chang Chi Kyung Kim Min-Kyung Kim Woo‐Keun Seo Kyungmi Oh
author_sort	Yoonkyung Chang
title	Insulin resistance is associated with poor functional outcome after acute ischemic stroke in non-diabetic patients
title_short	Insulin resistance is associated with poor functional outcome after acute ischemic stroke in non-diabetic patients
title_full	Insulin resistance is associated with poor functional outcome after acute ischemic stroke in non-diabetic patients
title_fullStr	Insulin resistance is associated with poor functional outcome after acute ischemic stroke in non-diabetic patients
title_full_unstemmed	Insulin resistance is associated with poor functional outcome after acute ischemic stroke in non-diabetic patients
title_sort	insulin resistance is associated with poor functional outcome after acute ischemic stroke in non-diabetic patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f14aa765648242be8d9c43d64fbbcd89
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Insulin resistance is associated with poor functional outcome after acute ischemic stroke in non-diabetic patients

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