Detecting awareness in the vegetative state: electroencephalographic evidence for attempted movements to command.

Patients in the Vegetative State (VS) do not produce overt motor behavior to command and are therefore considered to be unaware of themselves and of their environments. However, we recently showed that high-density electroencephalography (EEG) can be used to detect covert command-following in some V...

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Autores principales:	Damian Cruse, Srivas Chennu, Davinia Fernández-Espejo, William L Payne, G Bryan Young, Adrian M Owen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f14bc850acbd4590875d3b3a717c3e2d
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spelling	oai:doaj.org-article:f14bc850acbd4590875d3b3a717c3e2d2021-11-18T08:07:50ZDetecting awareness in the vegetative state: electroencephalographic evidence for attempted movements to command.1932-620310.1371/journal.pone.0049933https://doaj.org/article/f14bc850acbd4590875d3b3a717c3e2d2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23185489/?tool=EBIhttps://doaj.org/toc/1932-6203Patients in the Vegetative State (VS) do not produce overt motor behavior to command and are therefore considered to be unaware of themselves and of their environments. However, we recently showed that high-density electroencephalography (EEG) can be used to detect covert command-following in some VS patients. Due to its portability and inexpensiveness, EEG assessments of awareness have the potential to contribute to a standard clinical protocol, thus improving diagnostic accuracy. However, this technique requires refinement and optimization if it is to be used widely as a clinical tool. We asked a patient who had been repeatedly diagnosed as VS for 12-years to try to move his left and right hands, between periods of rest, while EEG was recorded from four scalp electrodes. We identified appropriate and statistically reliable modulations of sensorimotor beta rhythms following commands to try to move, which could be significantly classified at a single-trial level. These reliable effects indicate that the patient attempted to follow the commands, and was therefore aware, but was unable to execute an overtly discernable action. The cognitive demands of this novel task are lower than those used previously and, crucially, allow for awareness to be determined on the basis of a 20-minute EEG recording made with only four electrodes. This approach makes EEG assessments of awareness clinically viable, and therefore has potential for inclusion in a standard assessment of awareness in the VS.Damian CruseSrivas ChennuDavinia Fernández-EspejoWilliam L PayneG Bryan YoungAdrian M OwenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e49933 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Damian Cruse Srivas Chennu Davinia Fernández-Espejo William L Payne G Bryan Young Adrian M Owen Detecting awareness in the vegetative state: electroencephalographic evidence for attempted movements to command.
description	Patients in the Vegetative State (VS) do not produce overt motor behavior to command and are therefore considered to be unaware of themselves and of their environments. However, we recently showed that high-density electroencephalography (EEG) can be used to detect covert command-following in some VS patients. Due to its portability and inexpensiveness, EEG assessments of awareness have the potential to contribute to a standard clinical protocol, thus improving diagnostic accuracy. However, this technique requires refinement and optimization if it is to be used widely as a clinical tool. We asked a patient who had been repeatedly diagnosed as VS for 12-years to try to move his left and right hands, between periods of rest, while EEG was recorded from four scalp electrodes. We identified appropriate and statistically reliable modulations of sensorimotor beta rhythms following commands to try to move, which could be significantly classified at a single-trial level. These reliable effects indicate that the patient attempted to follow the commands, and was therefore aware, but was unable to execute an overtly discernable action. The cognitive demands of this novel task are lower than those used previously and, crucially, allow for awareness to be determined on the basis of a 20-minute EEG recording made with only four electrodes. This approach makes EEG assessments of awareness clinically viable, and therefore has potential for inclusion in a standard assessment of awareness in the VS.
format	article
author	Damian Cruse Srivas Chennu Davinia Fernández-Espejo William L Payne G Bryan Young Adrian M Owen
author_facet	Damian Cruse Srivas Chennu Davinia Fernández-Espejo William L Payne G Bryan Young Adrian M Owen
author_sort	Damian Cruse
title	Detecting awareness in the vegetative state: electroencephalographic evidence for attempted movements to command.
title_short	Detecting awareness in the vegetative state: electroencephalographic evidence for attempted movements to command.
title_full	Detecting awareness in the vegetative state: electroencephalographic evidence for attempted movements to command.
title_fullStr	Detecting awareness in the vegetative state: electroencephalographic evidence for attempted movements to command.
title_full_unstemmed	Detecting awareness in the vegetative state: electroencephalographic evidence for attempted movements to command.
title_sort	detecting awareness in the vegetative state: electroencephalographic evidence for attempted movements to command.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/f14bc850acbd4590875d3b3a717c3e2d
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Detecting awareness in the vegetative state: electroencephalographic evidence for attempted movements to command.

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