Analysis of pupillometer results according to disease stage in patients with Parkinson’s disease

Abstract We performed pupillometer testing on 132 patients with Parkinson’s disease, stratified into two groups according to the disease stage. Neurological examinations and pupillometry were performed in the ON state. Patients in the Hoehn and Yahr stages 1 and 2 comprised the early group, and pati...

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Autores principales:	Sooyeoun You, Jeong-Ho Hong, Joonsang Yoo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f14e1d78ba024d678ab7e720ffe11f55
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spelling	oai:doaj.org-article:f14e1d78ba024d678ab7e720ffe11f552021-12-02T14:58:47ZAnalysis of pupillometer results according to disease stage in patients with Parkinson’s disease10.1038/s41598-021-97599-42045-2322https://doaj.org/article/f14e1d78ba024d678ab7e720ffe11f552021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97599-4https://doaj.org/toc/2045-2322Abstract We performed pupillometer testing on 132 patients with Parkinson’s disease, stratified into two groups according to the disease stage. Neurological examinations and pupillometry were performed in the ON state. Patients in the Hoehn and Yahr stages 1 and 2 comprised the early group, and patients in stages 3–5 formed the late group. We performed age- and sex-matched (2:1) propensity score matching to compensate for the effect of age on pupil light reflex. Eight pupillometer parameters were measured and compared between the two groups. After the propensity score matching, the early group had 64 patients and the late group had 32 patients. The late group had a longer disease duration and took a higher levodopa equivalent dose than the early group. The constriction velocity (P = 0.006) and maximum constriction velocity (P = 0.005) were significantly faster in the early group than in the late group. Pupil size, minimum diameter, and dilation velocity were similar in both groups. The pupillary contraction velocity decreased with the disease progression, suggesting that the progression of Parkinson’s disease could be identified by the pupil constriction velocity.Sooyeoun YouJeong-Ho HongJoonsang YooNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sooyeoun You Jeong-Ho Hong Joonsang Yoo Analysis of pupillometer results according to disease stage in patients with Parkinson’s disease
description	Abstract We performed pupillometer testing on 132 patients with Parkinson’s disease, stratified into two groups according to the disease stage. Neurological examinations and pupillometry were performed in the ON state. Patients in the Hoehn and Yahr stages 1 and 2 comprised the early group, and patients in stages 3–5 formed the late group. We performed age- and sex-matched (2:1) propensity score matching to compensate for the effect of age on pupil light reflex. Eight pupillometer parameters were measured and compared between the two groups. After the propensity score matching, the early group had 64 patients and the late group had 32 patients. The late group had a longer disease duration and took a higher levodopa equivalent dose than the early group. The constriction velocity (P = 0.006) and maximum constriction velocity (P = 0.005) were significantly faster in the early group than in the late group. Pupil size, minimum diameter, and dilation velocity were similar in both groups. The pupillary contraction velocity decreased with the disease progression, suggesting that the progression of Parkinson’s disease could be identified by the pupil constriction velocity.
format	article
author	Sooyeoun You Jeong-Ho Hong Joonsang Yoo
author_facet	Sooyeoun You Jeong-Ho Hong Joonsang Yoo
author_sort	Sooyeoun You
title	Analysis of pupillometer results according to disease stage in patients with Parkinson’s disease
title_short	Analysis of pupillometer results according to disease stage in patients with Parkinson’s disease
title_full	Analysis of pupillometer results according to disease stage in patients with Parkinson’s disease
title_fullStr	Analysis of pupillometer results according to disease stage in patients with Parkinson’s disease
title_full_unstemmed	Analysis of pupillometer results according to disease stage in patients with Parkinson’s disease
title_sort	analysis of pupillometer results according to disease stage in patients with parkinson’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f14e1d78ba024d678ab7e720ffe11f55
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Analysis of pupillometer results according to disease stage in patients with Parkinson’s disease

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