Functional language shift to the right hemisphere in patients with language-eloquent brain tumors.

<h4>Objectives</h4>Language function is mainly located within the left hemisphere of the brain, especially in right-handed subjects. However, functional MRI (fMRI) has demonstrated changes of language organization in patients with left-sided perisylvian lesions to the right hemisphere. B...

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Autores principales:	Sandro M Krieg, Nico Sollmann, Theresa Hauck, Sebastian Ille, Annette Foerschler, Bernhard Meyer, Florian Ringel
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f15206d5d954460fbf46603e4d9f2180
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spelling	oai:doaj.org-article:f15206d5d954460fbf46603e4d9f21802021-11-18T08:54:51ZFunctional language shift to the right hemisphere in patients with language-eloquent brain tumors.1932-620310.1371/journal.pone.0075403https://doaj.org/article/f15206d5d954460fbf46603e4d9f21802013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24069410/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objectives</h4>Language function is mainly located within the left hemisphere of the brain, especially in right-handed subjects. However, functional MRI (fMRI) has demonstrated changes of language organization in patients with left-sided perisylvian lesions to the right hemisphere. Because intracerebral lesions can impair fMRI, this study was designed to investigate human language plasticity with a virtual lesion model using repetitive navigated transcranial magnetic stimulation (rTMS).<h4>Experimental design</h4>Fifteen patients with lesions of left-sided language-eloquent brain areas and 50 healthy and purely right-handed participants underwent bilateral rTMS language mapping via an object-naming task. All patients were proven to have left-sided language function during awake surgery. The rTMS-induced language errors were categorized into 6 different error types. The error ratio (induced errors/number of stimulations) was determined for each brain region on both hemispheres. A hemispheric dominance ratio was then defined for each region as the quotient of the error ratio (left/right) of the corresponding area of both hemispheres (ratio >1 = left dominant; ratio <1 = right dominant).<h4>Results</h4>Patients with language-eloquent lesions showed a statistically significantly lower ratio than healthy participants concerning "all errors" and "all errors without hesitations", which indicates a higher participation of the right hemisphere in language function. Yet, there was no cortical region with pronounced difference in language dominance compared to the whole hemisphere.<h4>Conclusions</h4>This is the first study that shows by means of an anatomically accurate virtual lesion model that a shift of language function to the non-dominant hemisphere can occur.Sandro M KriegNico SollmannTheresa HauckSebastian IlleAnnette FoerschlerBernhard MeyerFlorian RingelPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e75403 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sandro M Krieg Nico Sollmann Theresa Hauck Sebastian Ille Annette Foerschler Bernhard Meyer Florian Ringel Functional language shift to the right hemisphere in patients with language-eloquent brain tumors.
description	<h4>Objectives</h4>Language function is mainly located within the left hemisphere of the brain, especially in right-handed subjects. However, functional MRI (fMRI) has demonstrated changes of language organization in patients with left-sided perisylvian lesions to the right hemisphere. Because intracerebral lesions can impair fMRI, this study was designed to investigate human language plasticity with a virtual lesion model using repetitive navigated transcranial magnetic stimulation (rTMS).<h4>Experimental design</h4>Fifteen patients with lesions of left-sided language-eloquent brain areas and 50 healthy and purely right-handed participants underwent bilateral rTMS language mapping via an object-naming task. All patients were proven to have left-sided language function during awake surgery. The rTMS-induced language errors were categorized into 6 different error types. The error ratio (induced errors/number of stimulations) was determined for each brain region on both hemispheres. A hemispheric dominance ratio was then defined for each region as the quotient of the error ratio (left/right) of the corresponding area of both hemispheres (ratio >1 = left dominant; ratio <1 = right dominant).<h4>Results</h4>Patients with language-eloquent lesions showed a statistically significantly lower ratio than healthy participants concerning "all errors" and "all errors without hesitations", which indicates a higher participation of the right hemisphere in language function. Yet, there was no cortical region with pronounced difference in language dominance compared to the whole hemisphere.<h4>Conclusions</h4>This is the first study that shows by means of an anatomically accurate virtual lesion model that a shift of language function to the non-dominant hemisphere can occur.
format	article
author	Sandro M Krieg Nico Sollmann Theresa Hauck Sebastian Ille Annette Foerschler Bernhard Meyer Florian Ringel
author_facet	Sandro M Krieg Nico Sollmann Theresa Hauck Sebastian Ille Annette Foerschler Bernhard Meyer Florian Ringel
author_sort	Sandro M Krieg
title	Functional language shift to the right hemisphere in patients with language-eloquent brain tumors.
title_short	Functional language shift to the right hemisphere in patients with language-eloquent brain tumors.
title_full	Functional language shift to the right hemisphere in patients with language-eloquent brain tumors.
title_fullStr	Functional language shift to the right hemisphere in patients with language-eloquent brain tumors.
title_full_unstemmed	Functional language shift to the right hemisphere in patients with language-eloquent brain tumors.
title_sort	functional language shift to the right hemisphere in patients with language-eloquent brain tumors.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/f15206d5d954460fbf46603e4d9f2180
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Functional language shift to the right hemisphere in patients with language-eloquent brain tumors.

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