Germline pathogenic variants of 11 breast cancer genes in 7,051 Japanese patients and 11,241 controls

Association between variants in 11 different genes and breast cancer risk has been established and sequencing of these genes is recommended to provide personalized diagnosis, therapy, and surveillance for the high-risk patients and their relatives. Here the authors analyse the frequency of germline...

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Autores principales:	Yukihide Momozawa, Yusuke Iwasaki, Michael T. Parsons, Yoichiro Kamatani, Atsushi Takahashi, Chieko Tamura, Toyomasa Katagiri, Teruhiko Yoshida, Seigo Nakamura, Kokichi Sugano, Yoshio Miki, Makoto Hirata, Koichi Matsuda, Amanda B. Spurdle, Michiaki Kubo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f152bcaf7fbb4ab986305cf674e86064
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spelling	oai:doaj.org-article:f152bcaf7fbb4ab986305cf674e860642021-12-02T17:32:32ZGermline pathogenic variants of 11 breast cancer genes in 7,051 Japanese patients and 11,241 controls10.1038/s41467-018-06581-82041-1723https://doaj.org/article/f152bcaf7fbb4ab986305cf674e860642018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06581-8https://doaj.org/toc/2041-1723Association between variants in 11 different genes and breast cancer risk has been established and sequencing of these genes is recommended to provide personalized diagnosis, therapy, and surveillance for the high-risk patients and their relatives. Here the authors analyse the frequency of germline pathogenic mutations in these genes specifically in a Japanese population.Yukihide MomozawaYusuke IwasakiMichael T. ParsonsYoichiro KamataniAtsushi TakahashiChieko TamuraToyomasa KatagiriTeruhiko YoshidaSeigo NakamuraKokichi SuganoYoshio MikiMakoto HirataKoichi MatsudaAmanda B. SpurdleMichiaki KuboNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yukihide Momozawa Yusuke Iwasaki Michael T. Parsons Yoichiro Kamatani Atsushi Takahashi Chieko Tamura Toyomasa Katagiri Teruhiko Yoshida Seigo Nakamura Kokichi Sugano Yoshio Miki Makoto Hirata Koichi Matsuda Amanda B. Spurdle Michiaki Kubo Germline pathogenic variants of 11 breast cancer genes in 7,051 Japanese patients and 11,241 controls
description	Association between variants in 11 different genes and breast cancer risk has been established and sequencing of these genes is recommended to provide personalized diagnosis, therapy, and surveillance for the high-risk patients and their relatives. Here the authors analyse the frequency of germline pathogenic mutations in these genes specifically in a Japanese population.
format	article
author	Yukihide Momozawa Yusuke Iwasaki Michael T. Parsons Yoichiro Kamatani Atsushi Takahashi Chieko Tamura Toyomasa Katagiri Teruhiko Yoshida Seigo Nakamura Kokichi Sugano Yoshio Miki Makoto Hirata Koichi Matsuda Amanda B. Spurdle Michiaki Kubo
author_facet	Yukihide Momozawa Yusuke Iwasaki Michael T. Parsons Yoichiro Kamatani Atsushi Takahashi Chieko Tamura Toyomasa Katagiri Teruhiko Yoshida Seigo Nakamura Kokichi Sugano Yoshio Miki Makoto Hirata Koichi Matsuda Amanda B. Spurdle Michiaki Kubo
author_sort	Yukihide Momozawa
title	Germline pathogenic variants of 11 breast cancer genes in 7,051 Japanese patients and 11,241 controls
title_short	Germline pathogenic variants of 11 breast cancer genes in 7,051 Japanese patients and 11,241 controls
title_full	Germline pathogenic variants of 11 breast cancer genes in 7,051 Japanese patients and 11,241 controls
title_fullStr	Germline pathogenic variants of 11 breast cancer genes in 7,051 Japanese patients and 11,241 controls
title_full_unstemmed	Germline pathogenic variants of 11 breast cancer genes in 7,051 Japanese patients and 11,241 controls
title_sort	germline pathogenic variants of 11 breast cancer genes in 7,051 japanese patients and 11,241 controls
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f152bcaf7fbb4ab986305cf674e86064
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Germline pathogenic variants of 11 breast cancer genes in 7,051 Japanese patients and 11,241 controls

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