Cilia locally synthesize proteins to sustain their ultrastructure and functions

Cilia are microtubule-based organelles containing proteins transported from the cell body. Here, the authors show that the multicilia of mouse ependymal cells contain ribosomal components, tubulin mRNA,18 S rRNA and nascent tubulin peptides, suggesting local translation in the ciliary compartment.

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Autores principales:	Kai Hao, Yawen Chen, Xiumin Yan, Xueliang Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f153ef30b907416d8975a2a3bce6b9d5
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id	oai:doaj.org-article:f153ef30b907416d8975a2a3bce6b9d5
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spelling	oai:doaj.org-article:f153ef30b907416d8975a2a3bce6b9d52021-12-05T12:21:48ZCilia locally synthesize proteins to sustain their ultrastructure and functions10.1038/s41467-021-27298-12041-1723https://doaj.org/article/f153ef30b907416d8975a2a3bce6b9d52021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27298-1https://doaj.org/toc/2041-1723Cilia are microtubule-based organelles containing proteins transported from the cell body. Here, the authors show that the multicilia of mouse ependymal cells contain ribosomal components, tubulin mRNA,18 S rRNA and nascent tubulin peptides, suggesting local translation in the ciliary compartment.Kai HaoYawen ChenXiumin YanXueliang ZhuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kai Hao Yawen Chen Xiumin Yan Xueliang Zhu Cilia locally synthesize proteins to sustain their ultrastructure and functions
description	Cilia are microtubule-based organelles containing proteins transported from the cell body. Here, the authors show that the multicilia of mouse ependymal cells contain ribosomal components, tubulin mRNA,18 S rRNA and nascent tubulin peptides, suggesting local translation in the ciliary compartment.
format	article
author	Kai Hao Yawen Chen Xiumin Yan Xueliang Zhu
author_facet	Kai Hao Yawen Chen Xiumin Yan Xueliang Zhu
author_sort	Kai Hao
title	Cilia locally synthesize proteins to sustain their ultrastructure and functions
title_short	Cilia locally synthesize proteins to sustain their ultrastructure and functions
title_full	Cilia locally synthesize proteins to sustain their ultrastructure and functions
title_fullStr	Cilia locally synthesize proteins to sustain their ultrastructure and functions
title_full_unstemmed	Cilia locally synthesize proteins to sustain their ultrastructure and functions
title_sort	cilia locally synthesize proteins to sustain their ultrastructure and functions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f153ef30b907416d8975a2a3bce6b9d5
work_keys_str_mv	AT kaihao cilialocallysynthesizeproteinstosustaintheirultrastructureandfunctions AT yawenchen cilialocallysynthesizeproteinstosustaintheirultrastructureandfunctions AT xiuminyan cilialocallysynthesizeproteinstosustaintheirultrastructureandfunctions AT xueliangzhu cilialocallysynthesizeproteinstosustaintheirultrastructureandfunctions
_version_	1718372051595558912

Cilia locally synthesize proteins to sustain their ultrastructure and functions

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