In vivo knockdown of TAK1 accelerates bone marrow proliferation/differentiation and induces systemic inflammation.

In vivo knockdown of TAK1 accelerates bone marrow proliferation/differentiation and induces systemic inflammation.

TAK1 (TGF-β Activated Kinase 1) is a MAPK kinase kinase, which activates the p38- and JNK-MAPK and NF-κB pathways downstream of receptors such as Toll-Like-, cytokine- and T-cell and B-cell receptors. Representing such an important node in the pro-inflammatory signal-transduction network, the functi...

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Détails bibliographiques
Auteurs principaux: Paul M Vink, Wendy M Smout, Lilian J Driessen-Engels, Alex M de Bruin, Dianne Delsing, Magda A Krajnc-Franken, Aswin J Jansen, Eric F Rovers, André A van Puijenbroek, Allard Kaptein, Martijn A Nolte, Anja Garritsen, Hans van Eenennaam
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2013
Sujets:
Medicine
R
Science
Q
Accès en ligne:https://doaj.org/article/f155c1e5db6e4d95b71327873beac492
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Internet

https://doaj.org/article/f155c1e5db6e4d95b71327873beac492

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