Effects of 5-aminolevulinic acid supplementation on home-based walking training achievement in middle-aged depressive women: randomized, double-blind, crossover pilot study

Effects of 5-aminolevulinic acid supplementation on home-based walking training achievement in middle-aged depressive women: randomized, double-blind, crossover pilot study

Abstract Depressive patients often experience difficulty in performing exercise due to physical and psychological barriers. We examined the effects of 5-aminolevulinic acid (ALA) with sodium ferrous citrate (SFC) supplementation during home-based walking training in middle-aged depressive women. Nin...

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Autores principales: Hiroshi Suzuki, Shizue Masuki, Akiyo Morikawa, Yu Ogawa, Yoshi-ichiro Kamijo, Kiwamu Takahashi, Motowo Nakajima, Hiroshi Nose
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Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/f156c4d480a04bc285a1def63af9db6f
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spelling oai:doaj.org-article:f156c4d480a04bc285a1def63af9db6f2021-12-02T12:32:09ZEffects of 5-aminolevulinic acid supplementation on home-based walking training achievement in middle-aged depressive women: randomized, double-blind, crossover pilot study10.1038/s41598-018-25452-22045-2322https://doaj.org/article/f156c4d480a04bc285a1def63af9db6f2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25452-2https://doaj.org/toc/2045-2322Abstract Depressive patients often experience difficulty in performing exercise due to physical and psychological barriers. We examined the effects of 5-aminolevulinic acid (ALA) with sodium ferrous citrate (SFC) supplementation during home-based walking training in middle-aged depressive women. Nine outpatients [53 ± 8 (SD) yr] with major depressive disorder participated in the pilot study with randomized, placebo-controlled, double-blind crossover design. They underwent two trials for 7 days, each performing interval walking training (IWT) with ALA + SFC (ALA + SFC) or placebo supplement intake (PLC) intermittently with >a 10-day washout period. For the first 6 days of each trial, exercise intensity for IWT was measured by accelerometry. Before and after each trial, subjects underwent a graded cycling test, and lactate concentration in plasma ([Lac−]p), oxygen consumption rate ($${\dot{{\bf{V}}}{\bf{O}}}_{{\bf{2}}}$$ V˙O2 ), and carbon dioxide production rate ($${\dot{{\bf{V}}}{\bf{\text{CO}}}}_{{\bf{2}}}$$ V˙CO2 ) were measured with depression severity by the Montgomery–Åsberg Depression Rating Scale (MADRS). We found that the increases in [Lac−]p, $${\dot{{\bf{V}}}{\bf{O}}}_{{\bf{2}}}$$ V˙O2 and $${\dot{{\bf{V}}}{\bf{\text{CO}}}}_{{\bf{2}}}$$ V˙CO2 during the test were attenuated only in ALA + SFC ([before vs. after] × workload; all, P < 0.01), accompanied by increased training days, impulse, and time at fast walking during IWT (all, P < 0.05) with decreased MADRS-score (P = 0.001). Thus, ALA + SFC supplementation increased IWT achievement to improve depressive symptoms in middle-aged women.Hiroshi SuzukiShizue MasukiAkiyo MorikawaYu OgawaYoshi-ichiro KamijoKiwamu TakahashiMotowo NakajimaHiroshi NoseNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Hiroshi Suzuki
Shizue Masuki
Akiyo Morikawa
Yu Ogawa
Yoshi-ichiro Kamijo
Kiwamu Takahashi
Motowo Nakajima
Hiroshi Nose
Effects of 5-aminolevulinic acid supplementation on home-based walking training achievement in middle-aged depressive women: randomized, double-blind, crossover pilot study
description Abstract Depressive patients often experience difficulty in performing exercise due to physical and psychological barriers. We examined the effects of 5-aminolevulinic acid (ALA) with sodium ferrous citrate (SFC) supplementation during home-based walking training in middle-aged depressive women. Nine outpatients [53 ± 8 (SD) yr] with major depressive disorder participated in the pilot study with randomized, placebo-controlled, double-blind crossover design. They underwent two trials for 7 days, each performing interval walking training (IWT) with ALA + SFC (ALA + SFC) or placebo supplement intake (PLC) intermittently with >a 10-day washout period. For the first 6 days of each trial, exercise intensity for IWT was measured by accelerometry. Before and after each trial, subjects underwent a graded cycling test, and lactate concentration in plasma ([Lac−]p), oxygen consumption rate ($${\dot{{\bf{V}}}{\bf{O}}}_{{\bf{2}}}$$ V˙O2 ), and carbon dioxide production rate ($${\dot{{\bf{V}}}{\bf{\text{CO}}}}_{{\bf{2}}}$$ V˙CO2 ) were measured with depression severity by the Montgomery–Åsberg Depression Rating Scale (MADRS). We found that the increases in [Lac−]p, $${\dot{{\bf{V}}}{\bf{O}}}_{{\bf{2}}}$$ V˙O2 and $${\dot{{\bf{V}}}{\bf{\text{CO}}}}_{{\bf{2}}}$$ V˙CO2 during the test were attenuated only in ALA + SFC ([before vs. after] × workload; all, P < 0.01), accompanied by increased training days, impulse, and time at fast walking during IWT (all, P < 0.05) with decreased MADRS-score (P = 0.001). Thus, ALA + SFC supplementation increased IWT achievement to improve depressive symptoms in middle-aged women.
format article
author Hiroshi Suzuki
Shizue Masuki
Akiyo Morikawa
Yu Ogawa
Yoshi-ichiro Kamijo
Kiwamu Takahashi
Motowo Nakajima
Hiroshi Nose
author_facet Hiroshi Suzuki
Shizue Masuki
Akiyo Morikawa
Yu Ogawa
Yoshi-ichiro Kamijo
Kiwamu Takahashi
Motowo Nakajima
Hiroshi Nose
author_sort Hiroshi Suzuki
title Effects of 5-aminolevulinic acid supplementation on home-based walking training achievement in middle-aged depressive women: randomized, double-blind, crossover pilot study
title_short Effects of 5-aminolevulinic acid supplementation on home-based walking training achievement in middle-aged depressive women: randomized, double-blind, crossover pilot study
title_full Effects of 5-aminolevulinic acid supplementation on home-based walking training achievement in middle-aged depressive women: randomized, double-blind, crossover pilot study
title_fullStr Effects of 5-aminolevulinic acid supplementation on home-based walking training achievement in middle-aged depressive women: randomized, double-blind, crossover pilot study
title_full_unstemmed Effects of 5-aminolevulinic acid supplementation on home-based walking training achievement in middle-aged depressive women: randomized, double-blind, crossover pilot study
title_sort effects of 5-aminolevulinic acid supplementation on home-based walking training achievement in middle-aged depressive women: randomized, double-blind, crossover pilot study
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/f156c4d480a04bc285a1def63af9db6f
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