Atrial natriuretic peptide and posterior pituitary neurohormone changes in patients with acute schizophrenia

Derya Guzel,1 Ahmet Bulent Yazici,2 Tugba Mutu Pek,2 Songul Doganay,1 Alime Burcin Saykan Simsek,2 Kadir Saglam,1 Caglar Turan,2 Esra Yazici2 1Department of Physiology, School of Medicine, Sakarya University, Sakarya, Turkey; 2Department of Psychiatry, School of Medicine, Sakarya University, Sakary...

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Autores principales:	Guzel D, Yazici AB, Mutu Pek T, Doganay S, Saykan Simsek AB, Saglam K, Turan C, Yazici E
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	schizophrenia oxytocin PANS GAF CGI AVP Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/f1573253a4214a5199fa0f75d0cb6a2d
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spelling	oai:doaj.org-article:f1573253a4214a5199fa0f75d0cb6a2d2021-12-02T00:43:11ZAtrial natriuretic peptide and posterior pituitary neurohormone changes in patients with acute schizophrenia1178-2021https://doaj.org/article/f1573253a4214a5199fa0f75d0cb6a2d2018-07-01T00:00:00Zhttps://www.dovepress.com/atrial-natriuretic-peptide-and-posterior-pituitary-neurohormone-change-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Derya Guzel,1 Ahmet Bulent Yazici,2 Tugba Mutu Pek,2 Songul Doganay,1 Alime Burcin Saykan Simsek,2 Kadir Saglam,1 Caglar Turan,2 Esra Yazici2 1Department of Physiology, School of Medicine, Sakarya University, Sakarya, Turkey; 2Department of Psychiatry, School of Medicine, Sakarya University, Sakarya, Turkey Objectives: Interactions between neuropeptides and psychiatric disorders have been investigated for many years. The aim of this study was to evaluate oxytocin (OXT), arginine-vasopressin (AVP), and atrial natriuretic peptide (ANP) and assess their interactions with each other, as well as investigate these changes with the manifestations of schizophrenia. Participants and methods: Thirty-four individuals having acute schizophrenia and 24 healthy individuals as the control group were included in the study. Positive and Negative Syndrome Scales, Global Assessment of Functionality score, and Clinical Global Impression (CGI) scores were measured. Serum hormone levels were analyzed using enzyme-linked immunosorbent assay and were compared with the clinical findings. Results: OXT levels were significantly lower and AVP levels were significantly higher in patients having acute schizophrenia than the control group. OXT was negatively correlated with Positive and Negative Syndrome Scales positive score and CGI score, while it was positively correlated with Global Assessment of Functionality score. AVP was negatively correlated with CGI score. ANP levels of the patients having schizophrenia were lower than the control group; however, there was no significant correlation with clinical findings. Conclusion: The obtained data indicate that the AVP level was higher, but OXT and ANP levels were lower in the patients having acute schizophrenia. Specifically OXT is related with reduced disease severity and increased functionality. Keywords: schizophrenia, oxytocin, PANS, GAF, CGI, AVPGuzel DYazici ABMutu Pek TDoganay SSaykan Simsek ABSaglam KTuran CYazici EDove Medical PressarticleschizophreniaoxytocinPANSGAFCGIAVPNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 1855-1860 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	schizophrenia oxytocin PANS GAF CGI AVP Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	schizophrenia oxytocin PANS GAF CGI AVP Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Guzel D Yazici AB Mutu Pek T Doganay S Saykan Simsek AB Saglam K Turan C Yazici E Atrial natriuretic peptide and posterior pituitary neurohormone changes in patients with acute schizophrenia
description	Derya Guzel,1 Ahmet Bulent Yazici,2 Tugba Mutu Pek,2 Songul Doganay,1 Alime Burcin Saykan Simsek,2 Kadir Saglam,1 Caglar Turan,2 Esra Yazici2 1Department of Physiology, School of Medicine, Sakarya University, Sakarya, Turkey; 2Department of Psychiatry, School of Medicine, Sakarya University, Sakarya, Turkey Objectives: Interactions between neuropeptides and psychiatric disorders have been investigated for many years. The aim of this study was to evaluate oxytocin (OXT), arginine-vasopressin (AVP), and atrial natriuretic peptide (ANP) and assess their interactions with each other, as well as investigate these changes with the manifestations of schizophrenia. Participants and methods: Thirty-four individuals having acute schizophrenia and 24 healthy individuals as the control group were included in the study. Positive and Negative Syndrome Scales, Global Assessment of Functionality score, and Clinical Global Impression (CGI) scores were measured. Serum hormone levels were analyzed using enzyme-linked immunosorbent assay and were compared with the clinical findings. Results: OXT levels were significantly lower and AVP levels were significantly higher in patients having acute schizophrenia than the control group. OXT was negatively correlated with Positive and Negative Syndrome Scales positive score and CGI score, while it was positively correlated with Global Assessment of Functionality score. AVP was negatively correlated with CGI score. ANP levels of the patients having schizophrenia were lower than the control group; however, there was no significant correlation with clinical findings. Conclusion: The obtained data indicate that the AVP level was higher, but OXT and ANP levels were lower in the patients having acute schizophrenia. Specifically OXT is related with reduced disease severity and increased functionality. Keywords: schizophrenia, oxytocin, PANS, GAF, CGI, AVP
format	article
author	Guzel D Yazici AB Mutu Pek T Doganay S Saykan Simsek AB Saglam K Turan C Yazici E
author_facet	Guzel D Yazici AB Mutu Pek T Doganay S Saykan Simsek AB Saglam K Turan C Yazici E
author_sort	Guzel D
title	Atrial natriuretic peptide and posterior pituitary neurohormone changes in patients with acute schizophrenia
title_short	Atrial natriuretic peptide and posterior pituitary neurohormone changes in patients with acute schizophrenia
title_full	Atrial natriuretic peptide and posterior pituitary neurohormone changes in patients with acute schizophrenia
title_fullStr	Atrial natriuretic peptide and posterior pituitary neurohormone changes in patients with acute schizophrenia
title_full_unstemmed	Atrial natriuretic peptide and posterior pituitary neurohormone changes in patients with acute schizophrenia
title_sort	atrial natriuretic peptide and posterior pituitary neurohormone changes in patients with acute schizophrenia
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/f1573253a4214a5199fa0f75d0cb6a2d
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Atrial natriuretic peptide and posterior pituitary neurohormone changes in patients with acute schizophrenia

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