The effect of the total small vessel disease burden on the structural brain network

Abstract Different cerebral small vessel disease (SVD) lesion types have been shown to disrupt structural brain network individually. Considering that they often coexist, we investigated the relation between their collective effect using the recently proposed total SVD score and structural brain net...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xiaopei Xu, Kui Kai Lau, Yuen Kwun Wong, Henry K. F. Mak, Edward S. Hui
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f1581b9c9f9b431786f2e013a02658ed
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f1581b9c9f9b431786f2e013a02658ed
record_format	dspace
spelling	oai:doaj.org-article:f1581b9c9f9b431786f2e013a02658ed2021-12-02T12:32:10ZThe effect of the total small vessel disease burden on the structural brain network10.1038/s41598-018-25917-42045-2322https://doaj.org/article/f1581b9c9f9b431786f2e013a02658ed2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25917-4https://doaj.org/toc/2045-2322Abstract Different cerebral small vessel disease (SVD) lesion types have been shown to disrupt structural brain network individually. Considering that they often coexist, we investigated the relation between their collective effect using the recently proposed total SVD score and structural brain network on MRI in 95 patients with first transient ischemic attack (TIA) or ischemic stroke. Fifty-nine patients with and 36 without any SVD lesions were included. The total SVD score was recorded. Diffusion tensor imaging was performed to estimate structural brain connections for subsequent brain connectivity analysis. The global efficiency and characteristic path length of the structural brain network are respectively lower and higher due to SVD. Lower nodal efficiency is also found in the insular, precuneus, supplementary motor area, paracentral lobule, putamen and hippocampus. The total SVD score is correlated with global network measures, the local clustering coefficient and nodal efficiency of hippocampus, and the nodal efficiency of paracentral lobule. We have successfully demonstrated that the disruption of global and local structural brain networks are associated with the increase in the overall SVD severity or burden of patients with TIA or first-time stroke.Xiaopei XuKui Kai LauYuen Kwun WongHenry K. F. MakEdward S. HuiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaopei Xu Kui Kai Lau Yuen Kwun Wong Henry K. F. Mak Edward S. Hui The effect of the total small vessel disease burden on the structural brain network
description	Abstract Different cerebral small vessel disease (SVD) lesion types have been shown to disrupt structural brain network individually. Considering that they often coexist, we investigated the relation between their collective effect using the recently proposed total SVD score and structural brain network on MRI in 95 patients with first transient ischemic attack (TIA) or ischemic stroke. Fifty-nine patients with and 36 without any SVD lesions were included. The total SVD score was recorded. Diffusion tensor imaging was performed to estimate structural brain connections for subsequent brain connectivity analysis. The global efficiency and characteristic path length of the structural brain network are respectively lower and higher due to SVD. Lower nodal efficiency is also found in the insular, precuneus, supplementary motor area, paracentral lobule, putamen and hippocampus. The total SVD score is correlated with global network measures, the local clustering coefficient and nodal efficiency of hippocampus, and the nodal efficiency of paracentral lobule. We have successfully demonstrated that the disruption of global and local structural brain networks are associated with the increase in the overall SVD severity or burden of patients with TIA or first-time stroke.
format	article
author	Xiaopei Xu Kui Kai Lau Yuen Kwun Wong Henry K. F. Mak Edward S. Hui
author_facet	Xiaopei Xu Kui Kai Lau Yuen Kwun Wong Henry K. F. Mak Edward S. Hui
author_sort	Xiaopei Xu
title	The effect of the total small vessel disease burden on the structural brain network
title_short	The effect of the total small vessel disease burden on the structural brain network
title_full	The effect of the total small vessel disease burden on the structural brain network
title_fullStr	The effect of the total small vessel disease burden on the structural brain network
title_full_unstemmed	The effect of the total small vessel disease burden on the structural brain network
title_sort	effect of the total small vessel disease burden on the structural brain network
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f1581b9c9f9b431786f2e013a02658ed
work_keys_str_mv	AT xiaopeixu theeffectofthetotalsmallvesseldiseaseburdenonthestructuralbrainnetwork AT kuikailau theeffectofthetotalsmallvesseldiseaseburdenonthestructuralbrainnetwork AT yuenkwunwong theeffectofthetotalsmallvesseldiseaseburdenonthestructuralbrainnetwork AT henrykfmak theeffectofthetotalsmallvesseldiseaseburdenonthestructuralbrainnetwork AT edwardshui theeffectofthetotalsmallvesseldiseaseburdenonthestructuralbrainnetwork AT xiaopeixu effectofthetotalsmallvesseldiseaseburdenonthestructuralbrainnetwork AT kuikailau effectofthetotalsmallvesseldiseaseburdenonthestructuralbrainnetwork AT yuenkwunwong effectofthetotalsmallvesseldiseaseburdenonthestructuralbrainnetwork AT henrykfmak effectofthetotalsmallvesseldiseaseburdenonthestructuralbrainnetwork AT edwardshui effectofthetotalsmallvesseldiseaseburdenonthestructuralbrainnetwork
_version_	1718394192939450368

The effect of the total small vessel disease burden on the structural brain network

Ejemplares similares