THE THE HEPARIN INDUCED THROMBOCYTOPENIA IN CARDIAC SURGERY PATIENTS

Objective: Combination of ‘4Ts’ clinical scoring system and Particle gel immunoassay to determine the frequency of heparin-induced thrombocytopenia during heparin treatment in cardiac surgery patients. Study Design: Prospective observational study. Place and Duration of Study: This study was c...

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Autores principales:	Shakila Khadim, Nuzhat Salamat, Saleem Ahmad Khan, Kifayatullah ., Nisaruddin ., Muhammad Abdul Naeem
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2020
Materias:	heparin-induced thrombocytopenia (hit) Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f15db2dea29b4d6f9d2f8d3dbc865075
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spelling	oai:doaj.org-article:f15db2dea29b4d6f9d2f8d3dbc8650752021-11-05T03:06:52ZTHE THE HEPARIN INDUCED THROMBOCYTOPENIA IN CARDIAC SURGERY PATIENTS0030-96482411-8842https://doaj.org/article/f15db2dea29b4d6f9d2f8d3dbc8650752020-12-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/4061/3094https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: Combination of ‘4Ts’ clinical scoring system and Particle gel immunoassay to determine the frequency of heparin-induced thrombocytopenia during heparin treatment in cardiac surgery patients. Study Design: Prospective observational study. Place and Duration of Study: This study was conducted in the Pathology Department, Army Medical College in collaboration with Armed Forced Institute of Cardiology and Armed Forced Institute of Transfusion, Rawalpindi, from Jan 2019 to Dec 2019. Methodology: A total of 115 suspected cases of heparin-induced thrombocytopenia irrespective of age and gender were included in the study. A clinical scoring system the ‘4Ts’ was used for the classification of patients based on probability into three groups such as low, intermediate, and high probability groups. For the detection of antibodies against heparin/platelet factor 4 complexes, the Particle gel immunoassay was used. Results: There were 39 (33.9%) females and 76 (66.1%) males, the age range of 20 to 86 ± 12.9 years. Among the low probability group, there was no positive result, 2 (2.3%) patients showed positive serological evidence in the intermediate probability group. In the high probability group, 4 (23.5%) patients showed positive results with the chosen assay. Conclusion: Heparin-induced thrombocytopenia was found an overall 5.2% of patients undergoing cardiac surgery receiving unfractionated heparin. A combination of ‘4Ts’ pretest clinical scoring systems followed by PaGIA constitutes a simple strategy to screen for heparin-induced thrombocytopenia in suspected patients. This will avoid serious complications if the detection is not delayed.Shakila KhadimNuzhat SalamatSaleem Ahmad KhanKifayatullah .Nisaruddin .Muhammad Abdul NaeemArmy Medical College Rawalpindiarticleheparin-induced thrombocytopenia (hit)MedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 70, Iss 6, Pp 1919-1924 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	heparin-induced thrombocytopenia (hit) Medicine R Medicine (General) R5-920
spellingShingle	heparin-induced thrombocytopenia (hit) Medicine R Medicine (General) R5-920 Shakila Khadim Nuzhat Salamat Saleem Ahmad Khan Kifayatullah . Nisaruddin . Muhammad Abdul Naeem THE THE HEPARIN INDUCED THROMBOCYTOPENIA IN CARDIAC SURGERY PATIENTS
description	Objective: Combination of ‘4Ts’ clinical scoring system and Particle gel immunoassay to determine the frequency of heparin-induced thrombocytopenia during heparin treatment in cardiac surgery patients. Study Design: Prospective observational study. Place and Duration of Study: This study was conducted in the Pathology Department, Army Medical College in collaboration with Armed Forced Institute of Cardiology and Armed Forced Institute of Transfusion, Rawalpindi, from Jan 2019 to Dec 2019. Methodology: A total of 115 suspected cases of heparin-induced thrombocytopenia irrespective of age and gender were included in the study. A clinical scoring system the ‘4Ts’ was used for the classification of patients based on probability into three groups such as low, intermediate, and high probability groups. For the detection of antibodies against heparin/platelet factor 4 complexes, the Particle gel immunoassay was used. Results: There were 39 (33.9%) females and 76 (66.1%) males, the age range of 20 to 86 ± 12.9 years. Among the low probability group, there was no positive result, 2 (2.3%) patients showed positive serological evidence in the intermediate probability group. In the high probability group, 4 (23.5%) patients showed positive results with the chosen assay. Conclusion: Heparin-induced thrombocytopenia was found an overall 5.2% of patients undergoing cardiac surgery receiving unfractionated heparin. A combination of ‘4Ts’ pretest clinical scoring systems followed by PaGIA constitutes a simple strategy to screen for heparin-induced thrombocytopenia in suspected patients. This will avoid serious complications if the detection is not delayed.
format	article
author	Shakila Khadim Nuzhat Salamat Saleem Ahmad Khan Kifayatullah . Nisaruddin . Muhammad Abdul Naeem
author_facet	Shakila Khadim Nuzhat Salamat Saleem Ahmad Khan Kifayatullah . Nisaruddin . Muhammad Abdul Naeem
author_sort	Shakila Khadim
title	THE THE HEPARIN INDUCED THROMBOCYTOPENIA IN CARDIAC SURGERY PATIENTS
title_short	THE THE HEPARIN INDUCED THROMBOCYTOPENIA IN CARDIAC SURGERY PATIENTS
title_full	THE THE HEPARIN INDUCED THROMBOCYTOPENIA IN CARDIAC SURGERY PATIENTS
title_fullStr	THE THE HEPARIN INDUCED THROMBOCYTOPENIA IN CARDIAC SURGERY PATIENTS
title_full_unstemmed	THE THE HEPARIN INDUCED THROMBOCYTOPENIA IN CARDIAC SURGERY PATIENTS
title_sort	the heparin induced thrombocytopenia in cardiac surgery patients
publisher	Army Medical College Rawalpindi
publishDate	2020
url	https://doaj.org/article/f15db2dea29b4d6f9d2f8d3dbc865075
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THE THE HEPARIN INDUCED THROMBOCYTOPENIA IN CARDIAC SURGERY PATIENTS

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