A Short Course Computer-assisted Cognitive Remediation in Patients with Schizophrenia Spectrum Disorders: A Randomized Clinical Trial

Introduction: Cognitive Remediation Therapy (CRT) is used to improve cognitive functioning in patients with Schizophrenia Spectrum Disorders (SSDs). Most of the previous studies had incorporated a long rehabilitation program. This study aimed to evaluate the effects of a short and easy to implement...

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Autores principales:	Samira Hatami, Zahra Mirsepassi, Azadeh Sedighnia, Mehdi Tehranidoost, Maryam Masoomi, Vandad Sharifi
Formato:	article
Lenguaje:	EN
Publicado:	Iran University of Medical Sciences 2021
Materias:	cognitive remediation schizophrenia cognitive rehabilitation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/f15ede159dcc45d095d67b76d0179ce7
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spelling	oai:doaj.org-article:f15ede159dcc45d095d67b76d0179ce72021-12-05T08:43:44ZA Short Course Computer-assisted Cognitive Remediation in Patients with Schizophrenia Spectrum Disorders: A Randomized Clinical Trial2008-126X2228-7442https://doaj.org/article/f15ede159dcc45d095d67b76d0179ce72021-07-01T00:00:00Zhttp://bcn.iums.ac.ir/article-1-2025-en.htmlhttps://doaj.org/toc/2008-126Xhttps://doaj.org/toc/2228-7442Introduction: Cognitive Remediation Therapy (CRT) is used to improve cognitive functioning in patients with Schizophrenia Spectrum Disorders (SSDs). Most of the previous studies had incorporated a long rehabilitation program. This study aimed to evaluate the effects of a short and easy to implement computer-based CRT on cognitive performance in patients with SSDs using a randomized controlled trial design. Methods: Sixty-Two patients with SSDs were enrolled in Roozbeh Hospital (Tehran City, Iran); they were randomized to either receive a CRT program added to the standard pharmacological treatment (n=31) or the standard treatment alone (n=31). The remediation consisted of 10 sessions of CRT provided 2-3 times a week applying the Cogpack software. The cognitive performance was assessed in attention, memory, and executive functions before and after the intervention using the respective tests of the Cambridge Neuropsychological Test Automated Battery (CANTAB). Results: This study did not demonstrate any significant improvement in attention and executive function between the experimental and control group. However, we observed modest improvements in some aspects of visual memory (first trial memory score, F=9.152, P<0.001, Cohen’s d=0.40; mean errors to success, F=6.991, P=0.011, Cohen’s d=0.14; stages completed on the first trial, F=7.155, P=0. 010, Cohen’s d=0.71; total errors, F=5.730, P=0.020, Cohen’s d=0.53). Conclusion: We observed only modest improvements in the patients’ cognitive functioning after a short course of CRT. The short duration of the training and lack of a comprehensive rehabilitation plan may explain the obtained findings.Samira HatamiZahra MirsepassiAzadeh SedighniaMehdi TehranidoostMaryam MasoomiVandad SharifiIran University of Medical Sciencesarticlecognitive remediationschizophreniacognitive rehabilitationNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBasic and Clinical Neuroscience, Vol 12, Iss 4, Pp 551-562 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cognitive remediation schizophrenia cognitive rehabilitation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	cognitive remediation schizophrenia cognitive rehabilitation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Samira Hatami Zahra Mirsepassi Azadeh Sedighnia Mehdi Tehranidoost Maryam Masoomi Vandad Sharifi A Short Course Computer-assisted Cognitive Remediation in Patients with Schizophrenia Spectrum Disorders: A Randomized Clinical Trial
description	Introduction: Cognitive Remediation Therapy (CRT) is used to improve cognitive functioning in patients with Schizophrenia Spectrum Disorders (SSDs). Most of the previous studies had incorporated a long rehabilitation program. This study aimed to evaluate the effects of a short and easy to implement computer-based CRT on cognitive performance in patients with SSDs using a randomized controlled trial design. Methods: Sixty-Two patients with SSDs were enrolled in Roozbeh Hospital (Tehran City, Iran); they were randomized to either receive a CRT program added to the standard pharmacological treatment (n=31) or the standard treatment alone (n=31). The remediation consisted of 10 sessions of CRT provided 2-3 times a week applying the Cogpack software. The cognitive performance was assessed in attention, memory, and executive functions before and after the intervention using the respective tests of the Cambridge Neuropsychological Test Automated Battery (CANTAB). Results: This study did not demonstrate any significant improvement in attention and executive function between the experimental and control group. However, we observed modest improvements in some aspects of visual memory (first trial memory score, F=9.152, P<0.001, Cohen’s d=0.40; mean errors to success, F=6.991, P=0.011, Cohen’s d=0.14; stages completed on the first trial, F=7.155, P=0. 010, Cohen’s d=0.71; total errors, F=5.730, P=0.020, Cohen’s d=0.53). Conclusion: We observed only modest improvements in the patients’ cognitive functioning after a short course of CRT. The short duration of the training and lack of a comprehensive rehabilitation plan may explain the obtained findings.
format	article
author	Samira Hatami Zahra Mirsepassi Azadeh Sedighnia Mehdi Tehranidoost Maryam Masoomi Vandad Sharifi
author_facet	Samira Hatami Zahra Mirsepassi Azadeh Sedighnia Mehdi Tehranidoost Maryam Masoomi Vandad Sharifi
author_sort	Samira Hatami
title	A Short Course Computer-assisted Cognitive Remediation in Patients with Schizophrenia Spectrum Disorders: A Randomized Clinical Trial
title_short	A Short Course Computer-assisted Cognitive Remediation in Patients with Schizophrenia Spectrum Disorders: A Randomized Clinical Trial
title_full	A Short Course Computer-assisted Cognitive Remediation in Patients with Schizophrenia Spectrum Disorders: A Randomized Clinical Trial
title_fullStr	A Short Course Computer-assisted Cognitive Remediation in Patients with Schizophrenia Spectrum Disorders: A Randomized Clinical Trial
title_full_unstemmed	A Short Course Computer-assisted Cognitive Remediation in Patients with Schizophrenia Spectrum Disorders: A Randomized Clinical Trial
title_sort	short course computer-assisted cognitive remediation in patients with schizophrenia spectrum disorders: a randomized clinical trial
publisher	Iran University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/f15ede159dcc45d095d67b76d0179ce7
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A Short Course Computer-assisted Cognitive Remediation in Patients with Schizophrenia Spectrum Disorders: A Randomized Clinical Trial

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