Characteristics of Invasive Pulmonary Fungal Diseases Diagnosed by Pathological Examination

Objective. To explore the characteristics of invasive pulmonary fungal disease and the spectrum of pathogens causing invasive pulmonary fungal disease diagnosed by pathological examination using fungal stains. Methods. Patients with an invasive pulmonary fungal disease diagnosed by histopathological...

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Autores principales:	Dong Zhang, Xin Li, Junquan Zhang, Junping Wu, Xin Sun
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Infectious and parasitic diseases RC109-216 Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/f161622db2a44086b53233b3f156dc2f
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spelling	oai:doaj.org-article:f161622db2a44086b53233b3f156dc2f2021-11-08T02:37:11ZCharacteristics of Invasive Pulmonary Fungal Diseases Diagnosed by Pathological Examination1918-149310.1155/2021/5944518https://doaj.org/article/f161622db2a44086b53233b3f156dc2f2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/5944518https://doaj.org/toc/1918-1493Objective. To explore the characteristics of invasive pulmonary fungal disease and the spectrum of pathogens causing invasive pulmonary fungal disease diagnosed by pathological examination using fungal stains. Methods. Patients with an invasive pulmonary fungal disease diagnosed by histopathological analysis through the use of fungal stains (including Grocott’s methenamine silver and periodic acid-Schiff stains) were included in this study. The clinical records, radiological reports, pathology, and fungal culture results were reviewed. Results. Forty-eight invasive pulmonary fungal disease patients diagnosed by histopathological analysis in the Tianjin Haihe Hospital (including 8 cases obtained by pulmonary resection, 35 cases by fiberoptic bronchoscopic biopsy, and 5 cases by percutaneous lung biopsy) were included. There were 24 male and 24 female patients, aged 21–80 years (53 ± 13 years). There were 37 cases of pulmonary aspergillosis, 4 cases of pulmonary cryptococcosis, 2 cases of pulmonary mucormycosis, and 5 in which pathogens were not determined due to limited tissue availability. Among 48 cases, 32 specimens were submitted to fungal culture. No fungus was detected in culture, although 26 cases of fungus infections were diagnosed by histopathological analysis. Only 3 cases were consistent between histopathological and culture results. In 3 cases, the pathogen was identified as Aspergillus spp. by the histopathological analysis, while the contrasting fungal culture results identified Candida albicans. Conclusion. Candida albicans pneumonia was rare, while aspergillosis was common in invasive pulmonary fungal disease diagnosed by histopathological analysis. The majority of patients with an invasive pulmonary fungal disease were culture-negative. Although culture can clarify the fungal pathogen species, it has low sensitivity. Pathological examination with fungal stains has its advantages in diagnosing fungal disease; therefore, more attention should be paid to the role of pathological examination in the diagnosis of fungal disease.Dong ZhangXin LiJunquan ZhangJunping WuXin SunHindawi LimitedarticleInfectious and parasitic diseasesRC109-216MicrobiologyQR1-502ENCanadian Journal of Infectious Diseases and Medical Microbiology, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Infectious and parasitic diseases RC109-216 Microbiology QR1-502
spellingShingle	Infectious and parasitic diseases RC109-216 Microbiology QR1-502 Dong Zhang Xin Li Junquan Zhang Junping Wu Xin Sun Characteristics of Invasive Pulmonary Fungal Diseases Diagnosed by Pathological Examination
description	Objective. To explore the characteristics of invasive pulmonary fungal disease and the spectrum of pathogens causing invasive pulmonary fungal disease diagnosed by pathological examination using fungal stains. Methods. Patients with an invasive pulmonary fungal disease diagnosed by histopathological analysis through the use of fungal stains (including Grocott’s methenamine silver and periodic acid-Schiff stains) were included in this study. The clinical records, radiological reports, pathology, and fungal culture results were reviewed. Results. Forty-eight invasive pulmonary fungal disease patients diagnosed by histopathological analysis in the Tianjin Haihe Hospital (including 8 cases obtained by pulmonary resection, 35 cases by fiberoptic bronchoscopic biopsy, and 5 cases by percutaneous lung biopsy) were included. There were 24 male and 24 female patients, aged 21–80 years (53 ± 13 years). There were 37 cases of pulmonary aspergillosis, 4 cases of pulmonary cryptococcosis, 2 cases of pulmonary mucormycosis, and 5 in which pathogens were not determined due to limited tissue availability. Among 48 cases, 32 specimens were submitted to fungal culture. No fungus was detected in culture, although 26 cases of fungus infections were diagnosed by histopathological analysis. Only 3 cases were consistent between histopathological and culture results. In 3 cases, the pathogen was identified as Aspergillus spp. by the histopathological analysis, while the contrasting fungal culture results identified Candida albicans. Conclusion. Candida albicans pneumonia was rare, while aspergillosis was common in invasive pulmonary fungal disease diagnosed by histopathological analysis. The majority of patients with an invasive pulmonary fungal disease were culture-negative. Although culture can clarify the fungal pathogen species, it has low sensitivity. Pathological examination with fungal stains has its advantages in diagnosing fungal disease; therefore, more attention should be paid to the role of pathological examination in the diagnosis of fungal disease.
format	article
author	Dong Zhang Xin Li Junquan Zhang Junping Wu Xin Sun
author_facet	Dong Zhang Xin Li Junquan Zhang Junping Wu Xin Sun
author_sort	Dong Zhang
title	Characteristics of Invasive Pulmonary Fungal Diseases Diagnosed by Pathological Examination
title_short	Characteristics of Invasive Pulmonary Fungal Diseases Diagnosed by Pathological Examination
title_full	Characteristics of Invasive Pulmonary Fungal Diseases Diagnosed by Pathological Examination
title_fullStr	Characteristics of Invasive Pulmonary Fungal Diseases Diagnosed by Pathological Examination
title_full_unstemmed	Characteristics of Invasive Pulmonary Fungal Diseases Diagnosed by Pathological Examination
title_sort	characteristics of invasive pulmonary fungal diseases diagnosed by pathological examination
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/f161622db2a44086b53233b3f156dc2f
work_keys_str_mv	AT dongzhang characteristicsofinvasivepulmonaryfungaldiseasesdiagnosedbypathologicalexamination AT xinli characteristicsofinvasivepulmonaryfungaldiseasesdiagnosedbypathologicalexamination AT junquanzhang characteristicsofinvasivepulmonaryfungaldiseasesdiagnosedbypathologicalexamination AT junpingwu characteristicsofinvasivepulmonaryfungaldiseasesdiagnosedbypathologicalexamination AT xinsun characteristicsofinvasivepulmonaryfungaldiseasesdiagnosedbypathologicalexamination
_version_	1718443056590487552

Characteristics of Invasive Pulmonary Fungal Diseases Diagnosed by Pathological Examination

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