Duplex DNA engagement and RPA oppositely regulate the DNA-unwinding rate of CMG helicase

During eukaryotic chromosome replication cells utilize ring-shaped CMG helicase that separates the two strands of the DNA double helix. Here the authors reveal that CMG helicase activity is inhibited by duplex DNA engagement at the fork, which is relieved by binding of RPA to the lagging-strand temp...

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Autores principales:	Hazal B. Kose, Sherry Xie, George Cameron, Melania S. Strycharska, Hasan Yardimci
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f1629f52a95e404d9f34d3b0e1e99501
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id	oai:doaj.org-article:f1629f52a95e404d9f34d3b0e1e99501
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spelling	oai:doaj.org-article:f1629f52a95e404d9f34d3b0e1e995012021-12-02T16:26:33ZDuplex DNA engagement and RPA oppositely regulate the DNA-unwinding rate of CMG helicase10.1038/s41467-020-17443-72041-1723https://doaj.org/article/f1629f52a95e404d9f34d3b0e1e995012020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17443-7https://doaj.org/toc/2041-1723During eukaryotic chromosome replication cells utilize ring-shaped CMG helicase that separates the two strands of the DNA double helix. Here the authors reveal that CMG helicase activity is inhibited by duplex DNA engagement at the fork, which is relieved by binding of RPA to the lagging-strand template.Hazal B. KoseSherry XieGeorge CameronMelania S. StrycharskaHasan YardimciNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hazal B. Kose Sherry Xie George Cameron Melania S. Strycharska Hasan Yardimci Duplex DNA engagement and RPA oppositely regulate the DNA-unwinding rate of CMG helicase
description	During eukaryotic chromosome replication cells utilize ring-shaped CMG helicase that separates the two strands of the DNA double helix. Here the authors reveal that CMG helicase activity is inhibited by duplex DNA engagement at the fork, which is relieved by binding of RPA to the lagging-strand template.
format	article
author	Hazal B. Kose Sherry Xie George Cameron Melania S. Strycharska Hasan Yardimci
author_facet	Hazal B. Kose Sherry Xie George Cameron Melania S. Strycharska Hasan Yardimci
author_sort	Hazal B. Kose
title	Duplex DNA engagement and RPA oppositely regulate the DNA-unwinding rate of CMG helicase
title_short	Duplex DNA engagement and RPA oppositely regulate the DNA-unwinding rate of CMG helicase
title_full	Duplex DNA engagement and RPA oppositely regulate the DNA-unwinding rate of CMG helicase
title_fullStr	Duplex DNA engagement and RPA oppositely regulate the DNA-unwinding rate of CMG helicase
title_full_unstemmed	Duplex DNA engagement and RPA oppositely regulate the DNA-unwinding rate of CMG helicase
title_sort	duplex dna engagement and rpa oppositely regulate the dna-unwinding rate of cmg helicase
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f1629f52a95e404d9f34d3b0e1e99501
work_keys_str_mv	AT hazalbkose duplexdnaengagementandrpaoppositelyregulatethednaunwindingrateofcmghelicase AT sherryxie duplexdnaengagementandrpaoppositelyregulatethednaunwindingrateofcmghelicase AT georgecameron duplexdnaengagementandrpaoppositelyregulatethednaunwindingrateofcmghelicase AT melaniasstrycharska duplexdnaengagementandrpaoppositelyregulatethednaunwindingrateofcmghelicase AT hasanyardimci duplexdnaengagementandrpaoppositelyregulatethednaunwindingrateofcmghelicase
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Duplex DNA engagement and RPA oppositely regulate the DNA-unwinding rate of CMG helicase

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