DNA single-strand break-induced DNA damage response causes heart failure

DNA damage response (DDR) is activated in cardiomyocytes of the failing heart, but the type of DNA damage leading to DDR is unclear. Higoet al. show that in mice heart failure is caused in part by unrepaired DNA single-strand breaks in cardiomyocytes, which activate persistent DDR and trigger an NF-...

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Autores principales:	Tomoaki Higo, Atsuhiko T. Naito, Tomokazu Sumida, Masato Shibamoto, Katsuki Okada, Seitaro Nomura, Akito Nakagawa, Toshihiro Yamaguchi, Taku Sakai, Akihito Hashimoto, Yuki Kuramoto, Masamichi Ito, Shungo Hikoso, Hiroshi Akazawa, Jong-Kook Lee, Ichiro Shiojima, Peter J. McKinnon, Yasushi Sakata, Issei Komuro
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f167f426b5044f03bde4b9f896135c5c
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spelling	oai:doaj.org-article:f167f426b5044f03bde4b9f896135c5c2021-12-02T14:40:55ZDNA single-strand break-induced DNA damage response causes heart failure10.1038/ncomms151042041-1723https://doaj.org/article/f167f426b5044f03bde4b9f896135c5c2017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms15104https://doaj.org/toc/2041-1723DNA damage response (DDR) is activated in cardiomyocytes of the failing heart, but the type of DNA damage leading to DDR is unclear. Higoet al. show that in mice heart failure is caused in part by unrepaired DNA single-strand breaks in cardiomyocytes, which activate persistent DDR and trigger an NF-κB-dependent cardiac inflammation.Tomoaki HigoAtsuhiko T. NaitoTomokazu SumidaMasato ShibamotoKatsuki OkadaSeitaro NomuraAkito NakagawaToshihiro YamaguchiTaku SakaiAkihito HashimotoYuki KuramotoMasamichi ItoShungo HikosoHiroshi AkazawaJong-Kook LeeIchiro ShiojimaPeter J. McKinnonYasushi SakataIssei KomuroNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tomoaki Higo Atsuhiko T. Naito Tomokazu Sumida Masato Shibamoto Katsuki Okada Seitaro Nomura Akito Nakagawa Toshihiro Yamaguchi Taku Sakai Akihito Hashimoto Yuki Kuramoto Masamichi Ito Shungo Hikoso Hiroshi Akazawa Jong-Kook Lee Ichiro Shiojima Peter J. McKinnon Yasushi Sakata Issei Komuro DNA single-strand break-induced DNA damage response causes heart failure
description	DNA damage response (DDR) is activated in cardiomyocytes of the failing heart, but the type of DNA damage leading to DDR is unclear. Higoet al. show that in mice heart failure is caused in part by unrepaired DNA single-strand breaks in cardiomyocytes, which activate persistent DDR and trigger an NF-κB-dependent cardiac inflammation.
format	article
author	Tomoaki Higo Atsuhiko T. Naito Tomokazu Sumida Masato Shibamoto Katsuki Okada Seitaro Nomura Akito Nakagawa Toshihiro Yamaguchi Taku Sakai Akihito Hashimoto Yuki Kuramoto Masamichi Ito Shungo Hikoso Hiroshi Akazawa Jong-Kook Lee Ichiro Shiojima Peter J. McKinnon Yasushi Sakata Issei Komuro
author_facet	Tomoaki Higo Atsuhiko T. Naito Tomokazu Sumida Masato Shibamoto Katsuki Okada Seitaro Nomura Akito Nakagawa Toshihiro Yamaguchi Taku Sakai Akihito Hashimoto Yuki Kuramoto Masamichi Ito Shungo Hikoso Hiroshi Akazawa Jong-Kook Lee Ichiro Shiojima Peter J. McKinnon Yasushi Sakata Issei Komuro
author_sort	Tomoaki Higo
title	DNA single-strand break-induced DNA damage response causes heart failure
title_short	DNA single-strand break-induced DNA damage response causes heart failure
title_full	DNA single-strand break-induced DNA damage response causes heart failure
title_fullStr	DNA single-strand break-induced DNA damage response causes heart failure
title_full_unstemmed	DNA single-strand break-induced DNA damage response causes heart failure
title_sort	dna single-strand break-induced dna damage response causes heart failure
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f167f426b5044f03bde4b9f896135c5c
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DNA single-strand break-induced DNA damage response causes heart failure

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