Glycolytic regulation of cell rearrangement in angiogenesis

Glycolytic regulator PFKFB3 is a key player in vessel sprouting. Here the authors develop a computational model predicting that PFKFB3 drives endothelial cell rearrangement during vessel sprouting by promoting filopodia formation and reducing intercellular adhesion, and empirically validate this pre...

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Autores principales:	Bert Cruys, Brian W. Wong, Anna Kuchnio, Dries Verdegem, Anna Rita Cantelmo, Lena-Christin Conradi, Saar Vandekeere, Ann Bouché, Ivo Cornelissen, Stefan Vinckier, Roeland M. H. Merks, Elisabetta Dejana, Holger Gerhardt, Mieke Dewerchin, Katie Bentley, Peter Carmeliet
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f168b79c697d4569b921c383b7c0a3c0
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spelling	oai:doaj.org-article:f168b79c697d4569b921c383b7c0a3c02021-12-02T15:35:44ZGlycolytic regulation of cell rearrangement in angiogenesis10.1038/ncomms122402041-1723https://doaj.org/article/f168b79c697d4569b921c383b7c0a3c02016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12240https://doaj.org/toc/2041-1723Glycolytic regulator PFKFB3 is a key player in vessel sprouting. Here the authors develop a computational model predicting that PFKFB3 drives endothelial cell rearrangement during vessel sprouting by promoting filopodia formation and reducing intercellular adhesion, and empirically validate this prediction.Bert CruysBrian W. WongAnna KuchnioDries VerdegemAnna Rita CantelmoLena-Christin ConradiSaar VandekeereAnn BouchéIvo CornelissenStefan VinckierRoeland M. H. MerksElisabetta DejanaHolger GerhardtMieke DewerchinKatie BentleyPeter CarmelietNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bert Cruys Brian W. Wong Anna Kuchnio Dries Verdegem Anna Rita Cantelmo Lena-Christin Conradi Saar Vandekeere Ann Bouché Ivo Cornelissen Stefan Vinckier Roeland M. H. Merks Elisabetta Dejana Holger Gerhardt Mieke Dewerchin Katie Bentley Peter Carmeliet Glycolytic regulation of cell rearrangement in angiogenesis
description	Glycolytic regulator PFKFB3 is a key player in vessel sprouting. Here the authors develop a computational model predicting that PFKFB3 drives endothelial cell rearrangement during vessel sprouting by promoting filopodia formation and reducing intercellular adhesion, and empirically validate this prediction.
format	article
author	Bert Cruys Brian W. Wong Anna Kuchnio Dries Verdegem Anna Rita Cantelmo Lena-Christin Conradi Saar Vandekeere Ann Bouché Ivo Cornelissen Stefan Vinckier Roeland M. H. Merks Elisabetta Dejana Holger Gerhardt Mieke Dewerchin Katie Bentley Peter Carmeliet
author_facet	Bert Cruys Brian W. Wong Anna Kuchnio Dries Verdegem Anna Rita Cantelmo Lena-Christin Conradi Saar Vandekeere Ann Bouché Ivo Cornelissen Stefan Vinckier Roeland M. H. Merks Elisabetta Dejana Holger Gerhardt Mieke Dewerchin Katie Bentley Peter Carmeliet
author_sort	Bert Cruys
title	Glycolytic regulation of cell rearrangement in angiogenesis
title_short	Glycolytic regulation of cell rearrangement in angiogenesis
title_full	Glycolytic regulation of cell rearrangement in angiogenesis
title_fullStr	Glycolytic regulation of cell rearrangement in angiogenesis
title_full_unstemmed	Glycolytic regulation of cell rearrangement in angiogenesis
title_sort	glycolytic regulation of cell rearrangement in angiogenesis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/f168b79c697d4569b921c383b7c0a3c0
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Glycolytic regulation of cell rearrangement in angiogenesis

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