Sex differences in the longitudinal relationship of low-grade inflammation and echocardiographic measures in the Hoorn and FLEMENGHO Study.
<h4>Background</h4>This study aimed to determine the within-person and between-persons associations of low-grade inflammation (LGI) and endothelial dysfunction (ED) with echocardiographic measures related to diastolic dysfunction (DD) in two general populations and whether these associat...
Guardado en:
| Autores principales: | , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/f16a21d3f1e341fdb23700860bb5fdaf |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:f16a21d3f1e341fdb23700860bb5fdaf |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:f16a21d3f1e341fdb23700860bb5fdaf2021-11-25T06:19:20ZSex differences in the longitudinal relationship of low-grade inflammation and echocardiographic measures in the Hoorn and FLEMENGHO Study.1932-620310.1371/journal.pone.0251148https://doaj.org/article/f16a21d3f1e341fdb23700860bb5fdaf2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0251148https://doaj.org/toc/1932-6203<h4>Background</h4>This study aimed to determine the within-person and between-persons associations of low-grade inflammation (LGI) and endothelial dysfunction (ED) with echocardiographic measures related to diastolic dysfunction (DD) in two general populations and whether these associations differed by sex.<h4>Methods</h4>Biomarkers and echocardiographic measures were measured at both baseline and follow-up in the Hoorn Study (n = 383) and FLEMENGHO (n = 491). Individual biomarker levels were combined into either a Z-score of LGI (CRP, SAA, IL-6, IL-8, TNF-α and sICAM-1) or ED (sICAM-1, sVCAM-1, sE-selectin and sTM). Mixed models were used to determine within-person and between-persons associations of biomarker Z-scores with left ventricular ejection fraction (LVEF), left ventricular mass index (LVMI) and left atrial volume index (LAVI). These associations were adjusted for a-priori selected confounders.<h4>Results</h4>Overall Z-scores for LGI or ED were not associated with echocardiographic measures. Effect modification by sex was apparent for ED with LVEF in both cohorts (P-for interaction = 0.08 and 0.06), but stratified results were not consistent. Effect modification by sex was apparent for TNF-α in the Hoorn Study and E-selectin in FLEMENGHO with LVEF (P-for interaction≤0.05). In the Hoorn Study, women whose TNF-α levels increased with 1-SD over time had a decrease in LVEF of 2.2 (-4.5;0.01) %. In FLEMENGHO, men whose E-selectin levels increased with 1-SD over time had a decrease in LVEF of 1.6 (-2.7;-0.5) %.<h4>Conclusion</h4>Our study did not show consistent associations of LGI and ED with echocardiographic measures. Some evidence of effect modification by sex was present for ED and specific biomarkers.Sharon RemmelzwaalJoline W J BeulensPetra J M EldersCoen D A StehouwerZhenyu ZhangM Louis HandokoYolande AppelmanVanessa van EmpelStephane R B HeymansLutgarde ThijsJan A StaessenA Johanne van BallegooijenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0251148 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Sharon Remmelzwaal Joline W J Beulens Petra J M Elders Coen D A Stehouwer Zhenyu Zhang M Louis Handoko Yolande Appelman Vanessa van Empel Stephane R B Heymans Lutgarde Thijs Jan A Staessen A Johanne van Ballegooijen Sex differences in the longitudinal relationship of low-grade inflammation and echocardiographic measures in the Hoorn and FLEMENGHO Study. |
| description |
<h4>Background</h4>This study aimed to determine the within-person and between-persons associations of low-grade inflammation (LGI) and endothelial dysfunction (ED) with echocardiographic measures related to diastolic dysfunction (DD) in two general populations and whether these associations differed by sex.<h4>Methods</h4>Biomarkers and echocardiographic measures were measured at both baseline and follow-up in the Hoorn Study (n = 383) and FLEMENGHO (n = 491). Individual biomarker levels were combined into either a Z-score of LGI (CRP, SAA, IL-6, IL-8, TNF-α and sICAM-1) or ED (sICAM-1, sVCAM-1, sE-selectin and sTM). Mixed models were used to determine within-person and between-persons associations of biomarker Z-scores with left ventricular ejection fraction (LVEF), left ventricular mass index (LVMI) and left atrial volume index (LAVI). These associations were adjusted for a-priori selected confounders.<h4>Results</h4>Overall Z-scores for LGI or ED were not associated with echocardiographic measures. Effect modification by sex was apparent for ED with LVEF in both cohorts (P-for interaction = 0.08 and 0.06), but stratified results were not consistent. Effect modification by sex was apparent for TNF-α in the Hoorn Study and E-selectin in FLEMENGHO with LVEF (P-for interaction≤0.05). In the Hoorn Study, women whose TNF-α levels increased with 1-SD over time had a decrease in LVEF of 2.2 (-4.5;0.01) %. In FLEMENGHO, men whose E-selectin levels increased with 1-SD over time had a decrease in LVEF of 1.6 (-2.7;-0.5) %.<h4>Conclusion</h4>Our study did not show consistent associations of LGI and ED with echocardiographic measures. Some evidence of effect modification by sex was present for ED and specific biomarkers. |
| format |
article |
| author |
Sharon Remmelzwaal Joline W J Beulens Petra J M Elders Coen D A Stehouwer Zhenyu Zhang M Louis Handoko Yolande Appelman Vanessa van Empel Stephane R B Heymans Lutgarde Thijs Jan A Staessen A Johanne van Ballegooijen |
| author_facet |
Sharon Remmelzwaal Joline W J Beulens Petra J M Elders Coen D A Stehouwer Zhenyu Zhang M Louis Handoko Yolande Appelman Vanessa van Empel Stephane R B Heymans Lutgarde Thijs Jan A Staessen A Johanne van Ballegooijen |
| author_sort |
Sharon Remmelzwaal |
| title |
Sex differences in the longitudinal relationship of low-grade inflammation and echocardiographic measures in the Hoorn and FLEMENGHO Study. |
| title_short |
Sex differences in the longitudinal relationship of low-grade inflammation and echocardiographic measures in the Hoorn and FLEMENGHO Study. |
| title_full |
Sex differences in the longitudinal relationship of low-grade inflammation and echocardiographic measures in the Hoorn and FLEMENGHO Study. |
| title_fullStr |
Sex differences in the longitudinal relationship of low-grade inflammation and echocardiographic measures in the Hoorn and FLEMENGHO Study. |
| title_full_unstemmed |
Sex differences in the longitudinal relationship of low-grade inflammation and echocardiographic measures in the Hoorn and FLEMENGHO Study. |
| title_sort |
sex differences in the longitudinal relationship of low-grade inflammation and echocardiographic measures in the hoorn and flemengho study. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2021 |
| url |
https://doaj.org/article/f16a21d3f1e341fdb23700860bb5fdaf |
| work_keys_str_mv |
AT sharonremmelzwaal sexdifferencesinthelongitudinalrelationshipoflowgradeinflammationandechocardiographicmeasuresinthehoornandflemenghostudy AT jolinewjbeulens sexdifferencesinthelongitudinalrelationshipoflowgradeinflammationandechocardiographicmeasuresinthehoornandflemenghostudy AT petrajmelders sexdifferencesinthelongitudinalrelationshipoflowgradeinflammationandechocardiographicmeasuresinthehoornandflemenghostudy AT coendastehouwer sexdifferencesinthelongitudinalrelationshipoflowgradeinflammationandechocardiographicmeasuresinthehoornandflemenghostudy AT zhenyuzhang sexdifferencesinthelongitudinalrelationshipoflowgradeinflammationandechocardiographicmeasuresinthehoornandflemenghostudy AT mlouishandoko sexdifferencesinthelongitudinalrelationshipoflowgradeinflammationandechocardiographicmeasuresinthehoornandflemenghostudy AT yolandeappelman sexdifferencesinthelongitudinalrelationshipoflowgradeinflammationandechocardiographicmeasuresinthehoornandflemenghostudy AT vanessavanempel sexdifferencesinthelongitudinalrelationshipoflowgradeinflammationandechocardiographicmeasuresinthehoornandflemenghostudy AT stephanerbheymans sexdifferencesinthelongitudinalrelationshipoflowgradeinflammationandechocardiographicmeasuresinthehoornandflemenghostudy AT lutgardethijs sexdifferencesinthelongitudinalrelationshipoflowgradeinflammationandechocardiographicmeasuresinthehoornandflemenghostudy AT janastaessen sexdifferencesinthelongitudinalrelationshipoflowgradeinflammationandechocardiographicmeasuresinthehoornandflemenghostudy AT ajohannevanballegooijen sexdifferencesinthelongitudinalrelationshipoflowgradeinflammationandechocardiographicmeasuresinthehoornandflemenghostudy |
| _version_ |
1718413900475531264 |