Right stellate ganglion block improves learning and memory dysfunction and hippocampal injury in rats with sleep deprivation

Abstract Background Sleep deprivation (SD) often leads to complex detrimental consequences, though the mechanisms underlying these dysfunctional effects remain largely unknown. We investigated whether the right stellate ganglion block in rats can improve the spatial learning and memory dysfunction i...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Dongsheng Dai, Biqiong Zheng, Zenggui Yu, Shizhu Lin, Yijie Tang, Mengnan Chen, Peng Ke, Chengjie Zheng, Yanqing Chen, Xiaodan Wu
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Sleep deprivation Stellate ganglion block Spatial learning and memory Hippocampus Mechanism Anesthesiology RD78.3-87.3
Acceso en línea:	https://doaj.org/article/f16a3d36a9df4d42a6b515821b26092f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f16a3d36a9df4d42a6b515821b26092f
record_format	dspace
spelling	oai:doaj.org-article:f16a3d36a9df4d42a6b515821b26092f2021-11-14T12:11:43ZRight stellate ganglion block improves learning and memory dysfunction and hippocampal injury in rats with sleep deprivation10.1186/s12871-021-01486-41471-2253https://doaj.org/article/f16a3d36a9df4d42a6b515821b26092f2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12871-021-01486-4https://doaj.org/toc/1471-2253Abstract Background Sleep deprivation (SD) often leads to complex detrimental consequences, though the mechanisms underlying these dysfunctional effects remain largely unknown. We investigated whether the right stellate ganglion block in rats can improve the spatial learning and memory dysfunction induced by sleep deprivation by alleviating the damage of hippocampus in rats. Methods Sixty four male Sprague Dawley rats were randomly divided into four groups: Control, SD (sleep deprivation), SGB (stellate ganglion block) and SGB + SD (stellate ganglion block+ sleep deprivation) (n = 16). The SGB and SD + SGB groups were subjected to right stellate ganglion block through posterior approach method once per day. SD and SD + SGB groups were treated with modified multi-platform water environment method for 96 h sleep deprivation in rats and their body weights were analyzed. Histopathological changes of hippocampal neurons in rats and the expression of Caspase-3 in hippocampus of rats was detected by western blotting. ELISA was used to detect the content of IL-6, IL-1 in hippocampus and serum melatonin levels. Results Compared with the group SD, the spatial learning and memory function of the group SD + SGB was improved, the weight loss was alleviated, the pathological damage of the hippocampus was reduced and the expression of IL-6, IL-1β and Caspase-3 in the hippocampus was decreased. The content of rat serum melatonin was also increased. Conclusions The right stellate ganglion block can improve the spatial learning and memory dysfunction of rats with sleep deprivation, and the underlying mechanism may be related to alleviating the apoptosis and inflammation of hippocampus of rats with sleep deprivation.Dongsheng DaiBiqiong ZhengZenggui YuShizhu LinYijie TangMengnan ChenPeng KeChengjie ZhengYanqing ChenXiaodan WuBMCarticleSleep deprivationStellate ganglion blockSpatial learning and memoryHippocampusMechanismAnesthesiologyRD78.3-87.3ENBMC Anesthesiology, Vol 21, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Sleep deprivation Stellate ganglion block Spatial learning and memory Hippocampus Mechanism Anesthesiology RD78.3-87.3
spellingShingle	Sleep deprivation Stellate ganglion block Spatial learning and memory Hippocampus Mechanism Anesthesiology RD78.3-87.3 Dongsheng Dai Biqiong Zheng Zenggui Yu Shizhu Lin Yijie Tang Mengnan Chen Peng Ke Chengjie Zheng Yanqing Chen Xiaodan Wu Right stellate ganglion block improves learning and memory dysfunction and hippocampal injury in rats with sleep deprivation
description	Abstract Background Sleep deprivation (SD) often leads to complex detrimental consequences, though the mechanisms underlying these dysfunctional effects remain largely unknown. We investigated whether the right stellate ganglion block in rats can improve the spatial learning and memory dysfunction induced by sleep deprivation by alleviating the damage of hippocampus in rats. Methods Sixty four male Sprague Dawley rats were randomly divided into four groups: Control, SD (sleep deprivation), SGB (stellate ganglion block) and SGB + SD (stellate ganglion block+ sleep deprivation) (n = 16). The SGB and SD + SGB groups were subjected to right stellate ganglion block through posterior approach method once per day. SD and SD + SGB groups were treated with modified multi-platform water environment method for 96 h sleep deprivation in rats and their body weights were analyzed. Histopathological changes of hippocampal neurons in rats and the expression of Caspase-3 in hippocampus of rats was detected by western blotting. ELISA was used to detect the content of IL-6, IL-1 in hippocampus and serum melatonin levels. Results Compared with the group SD, the spatial learning and memory function of the group SD + SGB was improved, the weight loss was alleviated, the pathological damage of the hippocampus was reduced and the expression of IL-6, IL-1β and Caspase-3 in the hippocampus was decreased. The content of rat serum melatonin was also increased. Conclusions The right stellate ganglion block can improve the spatial learning and memory dysfunction of rats with sleep deprivation, and the underlying mechanism may be related to alleviating the apoptosis and inflammation of hippocampus of rats with sleep deprivation.
format	article
author	Dongsheng Dai Biqiong Zheng Zenggui Yu Shizhu Lin Yijie Tang Mengnan Chen Peng Ke Chengjie Zheng Yanqing Chen Xiaodan Wu
author_facet	Dongsheng Dai Biqiong Zheng Zenggui Yu Shizhu Lin Yijie Tang Mengnan Chen Peng Ke Chengjie Zheng Yanqing Chen Xiaodan Wu
author_sort	Dongsheng Dai
title	Right stellate ganglion block improves learning and memory dysfunction and hippocampal injury in rats with sleep deprivation
title_short	Right stellate ganglion block improves learning and memory dysfunction and hippocampal injury in rats with sleep deprivation
title_full	Right stellate ganglion block improves learning and memory dysfunction and hippocampal injury in rats with sleep deprivation
title_fullStr	Right stellate ganglion block improves learning and memory dysfunction and hippocampal injury in rats with sleep deprivation
title_full_unstemmed	Right stellate ganglion block improves learning and memory dysfunction and hippocampal injury in rats with sleep deprivation
title_sort	right stellate ganglion block improves learning and memory dysfunction and hippocampal injury in rats with sleep deprivation
publisher	BMC
publishDate	2021
url	https://doaj.org/article/f16a3d36a9df4d42a6b515821b26092f
work_keys_str_mv	AT dongshengdai rightstellateganglionblockimproveslearningandmemorydysfunctionandhippocampalinjuryinratswithsleepdeprivation AT biqiongzheng rightstellateganglionblockimproveslearningandmemorydysfunctionandhippocampalinjuryinratswithsleepdeprivation AT zengguiyu rightstellateganglionblockimproveslearningandmemorydysfunctionandhippocampalinjuryinratswithsleepdeprivation AT shizhulin rightstellateganglionblockimproveslearningandmemorydysfunctionandhippocampalinjuryinratswithsleepdeprivation AT yijietang rightstellateganglionblockimproveslearningandmemorydysfunctionandhippocampalinjuryinratswithsleepdeprivation AT mengnanchen rightstellateganglionblockimproveslearningandmemorydysfunctionandhippocampalinjuryinratswithsleepdeprivation AT pengke rightstellateganglionblockimproveslearningandmemorydysfunctionandhippocampalinjuryinratswithsleepdeprivation AT chengjiezheng rightstellateganglionblockimproveslearningandmemorydysfunctionandhippocampalinjuryinratswithsleepdeprivation AT yanqingchen rightstellateganglionblockimproveslearningandmemorydysfunctionandhippocampalinjuryinratswithsleepdeprivation AT xiaodanwu rightstellateganglionblockimproveslearningandmemorydysfunctionandhippocampalinjuryinratswithsleepdeprivation
_version_	1718429440963248128

Right stellate ganglion block improves learning and memory dysfunction and hippocampal injury in rats with sleep deprivation

Ejemplares similares