Sex differences in gut microbiota in patients with major depressive disorder

Jian-jun Chen,1–4 Peng Zheng,2,3 Yi-yun Liu,2,3 Xiao-gang Zhong,2,3 Hai-yang Wang,2,3 Yu-jie Guo,2,3 Peng Xie2,3 1Institute of Life Sciences, 2Department of Neurology, First Affiliated Hospital, 3Institute of Neuroscience, 4Joint International Research Laboratory of Reproduction and Devel...

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Autores principales:	Chen JJ, Zheng P, Liu YY, Zhong XG, Wang HY, Guo YJ, Xie P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	major depressive disorder MDD gut microbiota biomarker Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/f16af7f401124063a74889ed0747c541
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spelling	oai:doaj.org-article:f16af7f401124063a74889ed0747c5412021-12-02T06:34:34ZSex differences in gut microbiota in patients with major depressive disorder1178-2021https://doaj.org/article/f16af7f401124063a74889ed0747c5412018-02-01T00:00:00Zhttps://www.dovepress.com/sex-differences-in-gut-microbiota-in-patients-with-major-depressive-di-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Jian-jun Chen,1–4 Peng Zheng,2,3 Yi-yun Liu,2,3 Xiao-gang Zhong,2,3 Hai-yang Wang,2,3 Yu-jie Guo,2,3 Peng Xie2,3 1Institute of Life Sciences, 2Department of Neurology, First Affiliated Hospital, 3Institute of Neuroscience, 4Joint International Research Laboratory of Reproduction and Development, Chongqing Medical University, Chongqing, China Objective: Our previous studies found that disturbances in gut microbiota might have a causative role in the onset of major depressive disorder (MDD). The aim of this study was to investigate whether there were sex differences in gut microbiota in patients with MDD. Patients and methods: First-episode drug-naïve MDD patients and healthy controls were included. 16S rRNA gene sequences extracted from the fecal samples of the included subjects were analyzed. Principal-coordinate analysis and partial least squares-discriminant analysis were used to assess whether there were sex-specific gut microbiota. A random forest algorithm was used to identify the differential operational taxonomic units. Linear discriminant-analysis effect size was further used to identify the dominant sex-specific phylotypes responsible for the differences between MDD patients and healthy controls. Results: In total, 57 and 74 differential operational taxonomic units responsible for separating female and male MDD patients from their healthy counterparts were identified. Compared with their healthy counterparts, increased Actinobacteria and decreased Bacteroidetes levels were found in female and male MDD patients, respectively. The most differentially abundant bacterial taxa in female and male MDD patients belonged to phyla Actinobacteria and Bacteroidia, respectively. Meanwhile, female and male MDD patients had different dominant phylotypes. Conclusion: These results demonstrated that there were sex differences in gut microbiota in patients with MDD. The suitability of Actinobacteria and Bacteroidia as the sex-specific biomarkers for diagnosing MDD should be further explored. Keywords: major depressive disorder, MDD, gut microbiota, biomarkerChen JJZheng PLiu YYZhong XGWang HYGuo YJXie PDove Medical Pressarticlemajor depressive disorderMDDgut microbiotabiomarkerNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 647-655 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	major depressive disorder MDD gut microbiota biomarker Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	major depressive disorder MDD gut microbiota biomarker Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Chen JJ Zheng P Liu YY Zhong XG Wang HY Guo YJ Xie P Sex differences in gut microbiota in patients with major depressive disorder
description	Jian-jun Chen,1–4 Peng Zheng,2,3 Yi-yun Liu,2,3 Xiao-gang Zhong,2,3 Hai-yang Wang,2,3 Yu-jie Guo,2,3 Peng Xie2,3 1Institute of Life Sciences, 2Department of Neurology, First Affiliated Hospital, 3Institute of Neuroscience, 4Joint International Research Laboratory of Reproduction and Development, Chongqing Medical University, Chongqing, China Objective: Our previous studies found that disturbances in gut microbiota might have a causative role in the onset of major depressive disorder (MDD). The aim of this study was to investigate whether there were sex differences in gut microbiota in patients with MDD. Patients and methods: First-episode drug-naïve MDD patients and healthy controls were included. 16S rRNA gene sequences extracted from the fecal samples of the included subjects were analyzed. Principal-coordinate analysis and partial least squares-discriminant analysis were used to assess whether there were sex-specific gut microbiota. A random forest algorithm was used to identify the differential operational taxonomic units. Linear discriminant-analysis effect size was further used to identify the dominant sex-specific phylotypes responsible for the differences between MDD patients and healthy controls. Results: In total, 57 and 74 differential operational taxonomic units responsible for separating female and male MDD patients from their healthy counterparts were identified. Compared with their healthy counterparts, increased Actinobacteria and decreased Bacteroidetes levels were found in female and male MDD patients, respectively. The most differentially abundant bacterial taxa in female and male MDD patients belonged to phyla Actinobacteria and Bacteroidia, respectively. Meanwhile, female and male MDD patients had different dominant phylotypes. Conclusion: These results demonstrated that there were sex differences in gut microbiota in patients with MDD. The suitability of Actinobacteria and Bacteroidia as the sex-specific biomarkers for diagnosing MDD should be further explored. Keywords: major depressive disorder, MDD, gut microbiota, biomarker
format	article
author	Chen JJ Zheng P Liu YY Zhong XG Wang HY Guo YJ Xie P
author_facet	Chen JJ Zheng P Liu YY Zhong XG Wang HY Guo YJ Xie P
author_sort	Chen JJ
title	Sex differences in gut microbiota in patients with major depressive disorder
title_short	Sex differences in gut microbiota in patients with major depressive disorder
title_full	Sex differences in gut microbiota in patients with major depressive disorder
title_fullStr	Sex differences in gut microbiota in patients with major depressive disorder
title_full_unstemmed	Sex differences in gut microbiota in patients with major depressive disorder
title_sort	sex differences in gut microbiota in patients with major depressive disorder
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/f16af7f401124063a74889ed0747c541
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_version_	1718399847804960768

Sex differences in gut microbiota in patients with major depressive disorder

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