Overexpression of p16(INK4a) in urothelial carcinoma in situ is a marker for MAPK-mediated epithelial-mesenchymal transition but is not related to human papillomavirus infection.

Overexpression of p16(INK4a) in urothelial carcinoma in situ is a marker for MAPK-mediated epithelial-mesenchymal transition but is not related to human papillomavirus infection.

<h4>Background</h4>The role of human papillomavirus (HPV) in bladder carcinogenesis remains controversial. Overexpression of p16(INK4a), a surrogate marker for infection with oncogenic HPV in other tumours, has been described for urothelial carcinoma in situ (UCIS). Our goal was therefor...

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Autores principales: Julie Steinestel, Marcus V Cronauer, Johannes Müller, Andreas Al Ghazal, Peter Skowronek, Annette Arndt, Klaus Kraft, Mark Schrader, Andres J Schrader, Konrad Steinestel
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/f16bc1e74cf3469bb6a4d6b4af6c2d49
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