In vitro cytotoxicity of GO–DOx on FaDu squamous carcinoma cell lines

In vitro cytotoxicity of GO–DOx on FaDu squamous carcinoma cell lines

Manjri Singh,1 Parul Gupta,2 Richa Baronia,1 Priti Singh,1 Stalin Karuppiah,1 Rishi Shankar,3 Premendra D Dwivedi,2 Surinder P Singh1 1CSIR-National Physical Laboratory, New Delhi, 2CSIR-Indian Institute of Toxicology Research, Lucknow, Uttar Pradesh, 3Institute of Life Sciences, Ahmedabad Universi...

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Autores principales: Singh M, Gupta P, Baronia R, Singh P, Karuppiah S, Shanker R, Dwivedi PD, Singh SP
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2018
Materias:
Graphene Oxide (GO)
Doxorubicin (DOx)
Nanomedicine
Head and Neck Cancer (HNC)
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/f1774e2291bd4b29a9f816472748f9be
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spelling oai:doaj.org-article:f1774e2291bd4b29a9f816472748f9be2021-12-02T02:20:03ZIn vitro cytotoxicity of GO–DOx on FaDu squamous carcinoma cell lines1178-2013https://doaj.org/article/f1774e2291bd4b29a9f816472748f9be2018-03-01T00:00:00Zhttps://www.dovepress.com/in-vitro-cytotoxicity-of-go-dox-on-fadu-squamous-carcinoma-cell-lines-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Manjri Singh,1 Parul Gupta,2 Richa Baronia,1 Priti Singh,1 Stalin Karuppiah,1 Rishi Shankar,3 Premendra D Dwivedi,2 Surinder P Singh1 1CSIR-National Physical Laboratory, New Delhi, 2CSIR-Indian Institute of Toxicology Research, Lucknow, Uttar Pradesh, 3Institute of Life Sciences, Ahmedabad University, Ahmedabad, Gujarat, India Abstract: We have synthesized graphene oxide (GO) nanosheets using modified Hummer’s method and conjugated it with doxorubicin (DOx), an anticancer drug. Drug release kinetics from GO–DOx conjugate indicated the drug release at acidic pH. MTT assay performed on FaDu hypopharyngeal cancer cell lines revealed that the GO–DOx nanoconjugate inhibited cell proliferation more efficiently compared with pure DOx. Preliminary results indicate the potential of designed GO–DOx drug conjugate for head and neck cancer. Keywords: graphene oxide, doxorubicin, nanomedicine, head and neck cancerSingh MGupta PBaronia RSingh PKaruppiah SShanker RDwivedi PDSingh SPDove Medical PressarticleGraphene Oxide (GO)Doxorubicin (DOx)NanomedicineHead and Neck Cancer (HNC)Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 107-111 (2018)
institution DOAJ
collection DOAJ
language EN
topic Graphene Oxide (GO)
Doxorubicin (DOx)
Nanomedicine
Head and Neck Cancer (HNC)
Medicine (General)
R5-920
spellingShingle Graphene Oxide (GO)
Doxorubicin (DOx)
Nanomedicine
Head and Neck Cancer (HNC)
Medicine (General)
R5-920
Singh M
Gupta P
Baronia R
Singh P
Karuppiah S
Shanker R
Dwivedi PD
Singh SP
In vitro cytotoxicity of GO–DOx on FaDu squamous carcinoma cell lines
description Manjri Singh,1 Parul Gupta,2 Richa Baronia,1 Priti Singh,1 Stalin Karuppiah,1 Rishi Shankar,3 Premendra D Dwivedi,2 Surinder P Singh1 1CSIR-National Physical Laboratory, New Delhi, 2CSIR-Indian Institute of Toxicology Research, Lucknow, Uttar Pradesh, 3Institute of Life Sciences, Ahmedabad University, Ahmedabad, Gujarat, India Abstract: We have synthesized graphene oxide (GO) nanosheets using modified Hummer’s method and conjugated it with doxorubicin (DOx), an anticancer drug. Drug release kinetics from GO–DOx conjugate indicated the drug release at acidic pH. MTT assay performed on FaDu hypopharyngeal cancer cell lines revealed that the GO–DOx nanoconjugate inhibited cell proliferation more efficiently compared with pure DOx. Preliminary results indicate the potential of designed GO–DOx drug conjugate for head and neck cancer. Keywords: graphene oxide, doxorubicin, nanomedicine, head and neck cancer
format article
author Singh M
Gupta P
Baronia R
Singh P
Karuppiah S
Shanker R
Dwivedi PD
Singh SP
author_facet Singh M
Gupta P
Baronia R
Singh P
Karuppiah S
Shanker R
Dwivedi PD
Singh SP
author_sort Singh M
title In vitro cytotoxicity of GO–DOx on FaDu squamous carcinoma cell lines
title_short In vitro cytotoxicity of GO–DOx on FaDu squamous carcinoma cell lines
title_full In vitro cytotoxicity of GO–DOx on FaDu squamous carcinoma cell lines
title_fullStr In vitro cytotoxicity of GO–DOx on FaDu squamous carcinoma cell lines
title_full_unstemmed In vitro cytotoxicity of GO–DOx on FaDu squamous carcinoma cell lines
title_sort in vitro cytotoxicity of go–dox on fadu squamous carcinoma cell lines
publisher Dove Medical Press
publishDate 2018
url https://doaj.org/article/f1774e2291bd4b29a9f816472748f9be
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