Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection

Kupffer cells are more resistant to M. tuberculosis when compared with alveolar macrophages. Here the authors show that this distinction is caused by the presence of ornithine and imidazole in Kupffer cells and that these metabolites can drive autophagy and M. tuberculosis killing in alveolar macrop...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Ramya Sivangala Thandi, Rajesh Kumar Radhakrishnan, Deepak Tripathi, Padmaja Paidipally, Abul K. Azad, Larry S. Schlesinger, Buka Samten, Sachin Mulik, Ramakrishna Vankayalapati
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Q
Acceso en línea:https://doaj.org/article/f17c1a1cefad4df6a818b7dcf60e439b
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:f17c1a1cefad4df6a818b7dcf60e439b
record_format dspace
spelling oai:doaj.org-article:f17c1a1cefad4df6a818b7dcf60e439b2021-12-02T17:01:22ZOrnithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection10.1038/s41467-020-17310-52041-1723https://doaj.org/article/f17c1a1cefad4df6a818b7dcf60e439b2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17310-5https://doaj.org/toc/2041-1723Kupffer cells are more resistant to M. tuberculosis when compared with alveolar macrophages. Here the authors show that this distinction is caused by the presence of ornithine and imidazole in Kupffer cells and that these metabolites can drive autophagy and M. tuberculosis killing in alveolar macrophages when given intranasally to infected mice.Ramya Sivangala ThandiRajesh Kumar RadhakrishnanDeepak TripathiPadmaja PaidipallyAbul K. AzadLarry S. SchlesingerBuka SamtenSachin MulikRamakrishna VankayalapatiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ramya Sivangala Thandi
Rajesh Kumar Radhakrishnan
Deepak Tripathi
Padmaja Paidipally
Abul K. Azad
Larry S. Schlesinger
Buka Samten
Sachin Mulik
Ramakrishna Vankayalapati
Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection
description Kupffer cells are more resistant to M. tuberculosis when compared with alveolar macrophages. Here the authors show that this distinction is caused by the presence of ornithine and imidazole in Kupffer cells and that these metabolites can drive autophagy and M. tuberculosis killing in alveolar macrophages when given intranasally to infected mice.
format article
author Ramya Sivangala Thandi
Rajesh Kumar Radhakrishnan
Deepak Tripathi
Padmaja Paidipally
Abul K. Azad
Larry S. Schlesinger
Buka Samten
Sachin Mulik
Ramakrishna Vankayalapati
author_facet Ramya Sivangala Thandi
Rajesh Kumar Radhakrishnan
Deepak Tripathi
Padmaja Paidipally
Abul K. Azad
Larry S. Schlesinger
Buka Samten
Sachin Mulik
Ramakrishna Vankayalapati
author_sort Ramya Sivangala Thandi
title Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection
title_short Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection
title_full Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection
title_fullStr Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection
title_full_unstemmed Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection
title_sort ornithine-a urea cycle metabolite enhances autophagy and controls mycobacterium tuberculosis infection
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/f17c1a1cefad4df6a818b7dcf60e439b
work_keys_str_mv AT ramyasivangalathandi ornithineaureacyclemetaboliteenhancesautophagyandcontrolsmycobacteriumtuberculosisinfection
AT rajeshkumarradhakrishnan ornithineaureacyclemetaboliteenhancesautophagyandcontrolsmycobacteriumtuberculosisinfection
AT deepaktripathi ornithineaureacyclemetaboliteenhancesautophagyandcontrolsmycobacteriumtuberculosisinfection
AT padmajapaidipally ornithineaureacyclemetaboliteenhancesautophagyandcontrolsmycobacteriumtuberculosisinfection
AT abulkazad ornithineaureacyclemetaboliteenhancesautophagyandcontrolsmycobacteriumtuberculosisinfection
AT larrysschlesinger ornithineaureacyclemetaboliteenhancesautophagyandcontrolsmycobacteriumtuberculosisinfection
AT bukasamten ornithineaureacyclemetaboliteenhancesautophagyandcontrolsmycobacteriumtuberculosisinfection
AT sachinmulik ornithineaureacyclemetaboliteenhancesautophagyandcontrolsmycobacteriumtuberculosisinfection
AT ramakrishnavankayalapati ornithineaureacyclemetaboliteenhancesautophagyandcontrolsmycobacteriumtuberculosisinfection
_version_ 1718382186588012544