Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection
Kupffer cells are more resistant to M. tuberculosis when compared with alveolar macrophages. Here the authors show that this distinction is caused by the presence of ornithine and imidazole in Kupffer cells and that these metabolites can drive autophagy and M. tuberculosis killing in alveolar macrop...
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Nature Portfolio
2020
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oai:doaj.org-article:f17c1a1cefad4df6a818b7dcf60e439b2021-12-02T17:01:22ZOrnithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection10.1038/s41467-020-17310-52041-1723https://doaj.org/article/f17c1a1cefad4df6a818b7dcf60e439b2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17310-5https://doaj.org/toc/2041-1723Kupffer cells are more resistant to M. tuberculosis when compared with alveolar macrophages. Here the authors show that this distinction is caused by the presence of ornithine and imidazole in Kupffer cells and that these metabolites can drive autophagy and M. tuberculosis killing in alveolar macrophages when given intranasally to infected mice.Ramya Sivangala ThandiRajesh Kumar RadhakrishnanDeepak TripathiPadmaja PaidipallyAbul K. AzadLarry S. SchlesingerBuka SamtenSachin MulikRamakrishna VankayalapatiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020) |
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Science Q Ramya Sivangala Thandi Rajesh Kumar Radhakrishnan Deepak Tripathi Padmaja Paidipally Abul K. Azad Larry S. Schlesinger Buka Samten Sachin Mulik Ramakrishna Vankayalapati Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection |
description |
Kupffer cells are more resistant to M. tuberculosis when compared with alveolar macrophages. Here the authors show that this distinction is caused by the presence of ornithine and imidazole in Kupffer cells and that these metabolites can drive autophagy and M. tuberculosis killing in alveolar macrophages when given intranasally to infected mice. |
format |
article |
author |
Ramya Sivangala Thandi Rajesh Kumar Radhakrishnan Deepak Tripathi Padmaja Paidipally Abul K. Azad Larry S. Schlesinger Buka Samten Sachin Mulik Ramakrishna Vankayalapati |
author_facet |
Ramya Sivangala Thandi Rajesh Kumar Radhakrishnan Deepak Tripathi Padmaja Paidipally Abul K. Azad Larry S. Schlesinger Buka Samten Sachin Mulik Ramakrishna Vankayalapati |
author_sort |
Ramya Sivangala Thandi |
title |
Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection |
title_short |
Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection |
title_full |
Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection |
title_fullStr |
Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection |
title_full_unstemmed |
Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection |
title_sort |
ornithine-a urea cycle metabolite enhances autophagy and controls mycobacterium tuberculosis infection |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/f17c1a1cefad4df6a818b7dcf60e439b |
work_keys_str_mv |
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1718382186588012544 |