Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection

Kupffer cells are more resistant to M. tuberculosis when compared with alveolar macrophages. Here the authors show that this distinction is caused by the presence of ornithine and imidazole in Kupffer cells and that these metabolites can drive autophagy and M. tuberculosis killing in alveolar macrop...

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Auteurs principaux:	Ramya Sivangala Thandi, Rajesh Kumar Radhakrishnan, Deepak Tripathi, Padmaja Paidipally, Abul K. Azad, Larry S. Schlesinger, Buka Samten, Sachin Mulik, Ramakrishna Vankayalapati
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2020
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/f17c1a1cefad4df6a818b7dcf60e439b
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spelling	oai:doaj.org-article:f17c1a1cefad4df6a818b7dcf60e439b2021-12-02T17:01:22ZOrnithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection10.1038/s41467-020-17310-52041-1723https://doaj.org/article/f17c1a1cefad4df6a818b7dcf60e439b2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17310-5https://doaj.org/toc/2041-1723Kupffer cells are more resistant to M. tuberculosis when compared with alveolar macrophages. Here the authors show that this distinction is caused by the presence of ornithine and imidazole in Kupffer cells and that these metabolites can drive autophagy and M. tuberculosis killing in alveolar macrophages when given intranasally to infected mice.Ramya Sivangala ThandiRajesh Kumar RadhakrishnanDeepak TripathiPadmaja PaidipallyAbul K. AzadLarry S. SchlesingerBuka SamtenSachin MulikRamakrishna VankayalapatiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ramya Sivangala Thandi Rajesh Kumar Radhakrishnan Deepak Tripathi Padmaja Paidipally Abul K. Azad Larry S. Schlesinger Buka Samten Sachin Mulik Ramakrishna Vankayalapati Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection
description	Kupffer cells are more resistant to M. tuberculosis when compared with alveolar macrophages. Here the authors show that this distinction is caused by the presence of ornithine and imidazole in Kupffer cells and that these metabolites can drive autophagy and M. tuberculosis killing in alveolar macrophages when given intranasally to infected mice.
format	article
author	Ramya Sivangala Thandi Rajesh Kumar Radhakrishnan Deepak Tripathi Padmaja Paidipally Abul K. Azad Larry S. Schlesinger Buka Samten Sachin Mulik Ramakrishna Vankayalapati
author_facet	Ramya Sivangala Thandi Rajesh Kumar Radhakrishnan Deepak Tripathi Padmaja Paidipally Abul K. Azad Larry S. Schlesinger Buka Samten Sachin Mulik Ramakrishna Vankayalapati
author_sort	Ramya Sivangala Thandi
title	Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection
title_short	Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection
title_full	Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection
title_fullStr	Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection
title_full_unstemmed	Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection
title_sort	ornithine-a urea cycle metabolite enhances autophagy and controls mycobacterium tuberculosis infection
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f17c1a1cefad4df6a818b7dcf60e439b
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Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection

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