Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism

How neurons and neuronal activity regulate astrocyte functions is poorly understood. Haselet al. identify two large groups of astrocytic genes that are regulated by neuronal contact and synaptic activity respectively, with distinct roles in astrocytic function; interestingly, many of these genes are...

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Autores principales:	Philip Hasel, Owen Dando, Zoeb Jiwaji, Paul Baxter, Alison C. Todd, Samuel Heron, Nóra M. Márkus, Jamie McQueen, David W. Hampton, Megan Torvell, Sachin S. Tiwari, Sean McKay, Abel Eraso-Pichot, Antonio Zorzano, Roser Masgrau, Elena Galea, Siddharthan Chandran, David J. A. Wyllie, T. Ian Simpson, Giles E. Hardingham
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f17cb8505a5e4abe82484929859194ff
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spelling	oai:doaj.org-article:f17cb8505a5e4abe82484929859194ff2021-12-02T17:06:28ZNeurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism10.1038/ncomms151322041-1723https://doaj.org/article/f17cb8505a5e4abe82484929859194ff2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15132https://doaj.org/toc/2041-1723How neurons and neuronal activity regulate astrocyte functions is poorly understood. Haselet al. identify two large groups of astrocytic genes that are regulated by neuronal contact and synaptic activity respectively, with distinct roles in astrocytic function; interestingly, many of these genes are dysregulated in neurodegeneration.Philip HaselOwen DandoZoeb JiwajiPaul BaxterAlison C. ToddSamuel HeronNóra M. MárkusJamie McQueenDavid W. HamptonMegan TorvellSachin S. TiwariSean McKayAbel Eraso-PichotAntonio ZorzanoRoser MasgrauElena GaleaSiddharthan ChandranDavid J. A. WyllieT. Ian SimpsonGiles E. HardinghamNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Philip Hasel Owen Dando Zoeb Jiwaji Paul Baxter Alison C. Todd Samuel Heron Nóra M. Márkus Jamie McQueen David W. Hampton Megan Torvell Sachin S. Tiwari Sean McKay Abel Eraso-Pichot Antonio Zorzano Roser Masgrau Elena Galea Siddharthan Chandran David J. A. Wyllie T. Ian Simpson Giles E. Hardingham Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism
description	How neurons and neuronal activity regulate astrocyte functions is poorly understood. Haselet al. identify two large groups of astrocytic genes that are regulated by neuronal contact and synaptic activity respectively, with distinct roles in astrocytic function; interestingly, many of these genes are dysregulated in neurodegeneration.
format	article
author	Philip Hasel Owen Dando Zoeb Jiwaji Paul Baxter Alison C. Todd Samuel Heron Nóra M. Márkus Jamie McQueen David W. Hampton Megan Torvell Sachin S. Tiwari Sean McKay Abel Eraso-Pichot Antonio Zorzano Roser Masgrau Elena Galea Siddharthan Chandran David J. A. Wyllie T. Ian Simpson Giles E. Hardingham
author_facet	Philip Hasel Owen Dando Zoeb Jiwaji Paul Baxter Alison C. Todd Samuel Heron Nóra M. Márkus Jamie McQueen David W. Hampton Megan Torvell Sachin S. Tiwari Sean McKay Abel Eraso-Pichot Antonio Zorzano Roser Masgrau Elena Galea Siddharthan Chandran David J. A. Wyllie T. Ian Simpson Giles E. Hardingham
author_sort	Philip Hasel
title	Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism
title_short	Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism
title_full	Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism
title_fullStr	Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism
title_full_unstemmed	Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism
title_sort	neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f17cb8505a5e4abe82484929859194ff
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Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism

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