Hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis

Hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis

The application of STING agonists and the blockade of the SIRPα–CD47 signaling axis are emerging immunotherapeutic strategies. Here the authors show that hybrid cellular membrane nanovesicles loaded with a STING agonist or overexpressing high-affinity SIRPα variants can be exploited to promote anti-...

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Autores principales: Lang Rao, Lei Wu, Zhida Liu, Rui Tian, Guocan Yu, Zijian Zhou, Kuikun Yang, Hong-Gang Xiong, Anli Zhang, Guang-Tao Yu, Wenjing Sun, Han Xu, Jingya Guo, Andrew Li, Hongmin Chen, Zhi-Jun Sun, Yang-Xin Fu, Xiaoyuan Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/f17de9f800584c86b4d4c951356870bb
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Sumario:The application of STING agonists and the blockade of the SIRPα–CD47 signaling axis are emerging immunotherapeutic strategies. Here the authors show that hybrid cellular membrane nanovesicles loaded with a STING agonist or overexpressing high-affinity SIRPα variants can be exploited to promote anti-tumor immune responses.

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