Hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis

Hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis

The application of STING agonists and the blockade of the SIRPα–CD47 signaling axis are emerging immunotherapeutic strategies. Here the authors show that hybrid cellular membrane nanovesicles loaded with a STING agonist or overexpressing high-affinity SIRPα variants can be exploited to promote anti-...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Lang Rao, Lei Wu, Zhida Liu, Rui Tian, Guocan Yu, Zijian Zhou, Kuikun Yang, Hong-Gang Xiong, Anli Zhang, Guang-Tao Yu, Wenjing Sun, Han Xu, Jingya Guo, Andrew Li, Hongmin Chen, Zhi-Jun Sun, Yang-Xin Fu, Xiaoyuan Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/f17de9f800584c86b4d4c951356870bb
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:f17de9f800584c86b4d4c951356870bb
record_format dspace
spelling oai:doaj.org-article:f17de9f800584c86b4d4c951356870bb2021-12-02T17:18:07ZHybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis10.1038/s41467-020-18626-y2041-1723https://doaj.org/article/f17de9f800584c86b4d4c951356870bb2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18626-yhttps://doaj.org/toc/2041-1723The application of STING agonists and the blockade of the SIRPα–CD47 signaling axis are emerging immunotherapeutic strategies. Here the authors show that hybrid cellular membrane nanovesicles loaded with a STING agonist or overexpressing high-affinity SIRPα variants can be exploited to promote anti-tumor immune responses.Lang RaoLei WuZhida LiuRui TianGuocan YuZijian ZhouKuikun YangHong-Gang XiongAnli ZhangGuang-Tao YuWenjing SunHan XuJingya GuoAndrew LiHongmin ChenZhi-Jun SunYang-Xin FuXiaoyuan ChenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Lang Rao
Lei Wu
Zhida Liu
Rui Tian
Guocan Yu
Zijian Zhou
Kuikun Yang
Hong-Gang Xiong
Anli Zhang
Guang-Tao Yu
Wenjing Sun
Han Xu
Jingya Guo
Andrew Li
Hongmin Chen
Zhi-Jun Sun
Yang-Xin Fu
Xiaoyuan Chen
Hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis
description The application of STING agonists and the blockade of the SIRPα–CD47 signaling axis are emerging immunotherapeutic strategies. Here the authors show that hybrid cellular membrane nanovesicles loaded with a STING agonist or overexpressing high-affinity SIRPα variants can be exploited to promote anti-tumor immune responses.
format article
author Lang Rao
Lei Wu
Zhida Liu
Rui Tian
Guocan Yu
Zijian Zhou
Kuikun Yang
Hong-Gang Xiong
Anli Zhang
Guang-Tao Yu
Wenjing Sun
Han Xu
Jingya Guo
Andrew Li
Hongmin Chen
Zhi-Jun Sun
Yang-Xin Fu
Xiaoyuan Chen
author_facet Lang Rao
Lei Wu
Zhida Liu
Rui Tian
Guocan Yu
Zijian Zhou
Kuikun Yang
Hong-Gang Xiong
Anli Zhang
Guang-Tao Yu
Wenjing Sun
Han Xu
Jingya Guo
Andrew Li
Hongmin Chen
Zhi-Jun Sun
Yang-Xin Fu
Xiaoyuan Chen
author_sort Lang Rao
title Hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis
title_short Hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis
title_full Hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis
title_fullStr Hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis
title_full_unstemmed Hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis
title_sort hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/f17de9f800584c86b4d4c951356870bb
work_keys_str_mv AT langrao hybridcellularmembranenanovesiclesamplifymacrophageimmuneresponsesagainstcancerrecurrenceandmetastasis
AT leiwu hybridcellularmembranenanovesiclesamplifymacrophageimmuneresponsesagainstcancerrecurrenceandmetastasis
AT zhidaliu hybridcellularmembranenanovesiclesamplifymacrophageimmuneresponsesagainstcancerrecurrenceandmetastasis
AT ruitian hybridcellularmembranenanovesiclesamplifymacrophageimmuneresponsesagainstcancerrecurrenceandmetastasis
AT guocanyu hybridcellularmembranenanovesiclesamplifymacrophageimmuneresponsesagainstcancerrecurrenceandmetastasis
AT zijianzhou hybridcellularmembranenanovesiclesamplifymacrophageimmuneresponsesagainstcancerrecurrenceandmetastasis
AT kuikunyang hybridcellularmembranenanovesiclesamplifymacrophageimmuneresponsesagainstcancerrecurrenceandmetastasis
AT honggangxiong hybridcellularmembranenanovesiclesamplifymacrophageimmuneresponsesagainstcancerrecurrenceandmetastasis
AT anlizhang hybridcellularmembranenanovesiclesamplifymacrophageimmuneresponsesagainstcancerrecurrenceandmetastasis
AT guangtaoyu hybridcellularmembranenanovesiclesamplifymacrophageimmuneresponsesagainstcancerrecurrenceandmetastasis
AT wenjingsun hybridcellularmembranenanovesiclesamplifymacrophageimmuneresponsesagainstcancerrecurrenceandmetastasis
AT hanxu hybridcellularmembranenanovesiclesamplifymacrophageimmuneresponsesagainstcancerrecurrenceandmetastasis
AT jingyaguo hybridcellularmembranenanovesiclesamplifymacrophageimmuneresponsesagainstcancerrecurrenceandmetastasis
AT andrewli hybridcellularmembranenanovesiclesamplifymacrophageimmuneresponsesagainstcancerrecurrenceandmetastasis
AT hongminchen hybridcellularmembranenanovesiclesamplifymacrophageimmuneresponsesagainstcancerrecurrenceandmetastasis
AT zhijunsun hybridcellularmembranenanovesiclesamplifymacrophageimmuneresponsesagainstcancerrecurrenceandmetastasis
AT yangxinfu hybridcellularmembranenanovesiclesamplifymacrophageimmuneresponsesagainstcancerrecurrenceandmetastasis
AT xiaoyuanchen hybridcellularmembranenanovesiclesamplifymacrophageimmuneresponsesagainstcancerrecurrenceandmetastasis
_version_ 1718381176964513792

Ejemplares similares