Fungal endocarditis after type a dissection, a positive outcome from Candida parapsilosis prosthetic aortic valve endocarditis and aortic graft infection: A testament to multidisciplinary practice

Fungal endocarditis is associated with a very poor prognosis (mortality in excess of 50%) and the incidence is increasing due, in part, to the increased implantation of intra-cardiac devices and valve replacements. Diagnosis and treatment remain challenging, with the need for prolonged courses of du...

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Autores principales:	Fredrika Collins, Rhys D. Wenlock, Sally Curtis, Jonathan Hyde, P. Rachael James
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Candida parapsilosis Endocarditis Heart Valve Prosthesis Candidemia Antifungal agents Mycoses Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/f17f463e2d3f4ad3a391f5343c47bbba
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spelling	oai:doaj.org-article:f17f463e2d3f4ad3a391f5343c47bbba2021-11-14T04:35:25ZFungal endocarditis after type a dissection, a positive outcome from Candida parapsilosis prosthetic aortic valve endocarditis and aortic graft infection: A testament to multidisciplinary practice2590-170210.1016/j.clinpr.2021.100106https://doaj.org/article/f17f463e2d3f4ad3a391f5343c47bbba2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2590170221000431https://doaj.org/toc/2590-1702Fungal endocarditis is associated with a very poor prognosis (mortality in excess of 50%) and the incidence is increasing due, in part, to the increased implantation of intra-cardiac devices and valve replacements. Diagnosis and treatment remain challenging, with the need for prolonged courses of dual, parenteral anti-fungal therapy that have several drug-drug interactions and side effects that require protracted monitoring. Moreover, there is uncertainty on the optimal management strategy for fungal endocarditis as, given its rarity, much of the evidence comes from small observational studies. We report a case of Candida parapsilosis prosthetic valve endocarditis and aortic graft infection necessitating a high-risk redo aortic valve replacement. This case illustrates the important role of the multidisciplinary Endocarditis Team in achieving a good outcome, despite year-long treatment and geographical separation of patient from the regional centre and Endocarditis Team expertise.Fredrika CollinsRhys D. WenlockSally CurtisJonathan HydeP. Rachael JamesElsevierarticleCandida parapsilosisEndocarditisHeart Valve ProsthesisCandidemiaAntifungal agentsMycosesInfectious and parasitic diseasesRC109-216ENClinical Infection in Practice, Vol 12, Iss , Pp 100106- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Candida parapsilosis Endocarditis Heart Valve Prosthesis Candidemia Antifungal agents Mycoses Infectious and parasitic diseases RC109-216
spellingShingle	Candida parapsilosis Endocarditis Heart Valve Prosthesis Candidemia Antifungal agents Mycoses Infectious and parasitic diseases RC109-216 Fredrika Collins Rhys D. Wenlock Sally Curtis Jonathan Hyde P. Rachael James Fungal endocarditis after type a dissection, a positive outcome from Candida parapsilosis prosthetic aortic valve endocarditis and aortic graft infection: A testament to multidisciplinary practice
description	Fungal endocarditis is associated with a very poor prognosis (mortality in excess of 50%) and the incidence is increasing due, in part, to the increased implantation of intra-cardiac devices and valve replacements. Diagnosis and treatment remain challenging, with the need for prolonged courses of dual, parenteral anti-fungal therapy that have several drug-drug interactions and side effects that require protracted monitoring. Moreover, there is uncertainty on the optimal management strategy for fungal endocarditis as, given its rarity, much of the evidence comes from small observational studies. We report a case of Candida parapsilosis prosthetic valve endocarditis and aortic graft infection necessitating a high-risk redo aortic valve replacement. This case illustrates the important role of the multidisciplinary Endocarditis Team in achieving a good outcome, despite year-long treatment and geographical separation of patient from the regional centre and Endocarditis Team expertise.
format	article
author	Fredrika Collins Rhys D. Wenlock Sally Curtis Jonathan Hyde P. Rachael James
author_facet	Fredrika Collins Rhys D. Wenlock Sally Curtis Jonathan Hyde P. Rachael James
author_sort	Fredrika Collins
title	Fungal endocarditis after type a dissection, a positive outcome from Candida parapsilosis prosthetic aortic valve endocarditis and aortic graft infection: A testament to multidisciplinary practice
title_short	Fungal endocarditis after type a dissection, a positive outcome from Candida parapsilosis prosthetic aortic valve endocarditis and aortic graft infection: A testament to multidisciplinary practice
title_full	Fungal endocarditis after type a dissection, a positive outcome from Candida parapsilosis prosthetic aortic valve endocarditis and aortic graft infection: A testament to multidisciplinary practice
title_fullStr	Fungal endocarditis after type a dissection, a positive outcome from Candida parapsilosis prosthetic aortic valve endocarditis and aortic graft infection: A testament to multidisciplinary practice
title_full_unstemmed	Fungal endocarditis after type a dissection, a positive outcome from Candida parapsilosis prosthetic aortic valve endocarditis and aortic graft infection: A testament to multidisciplinary practice
title_sort	fungal endocarditis after type a dissection, a positive outcome from candida parapsilosis prosthetic aortic valve endocarditis and aortic graft infection: a testament to multidisciplinary practice
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/f17f463e2d3f4ad3a391f5343c47bbba
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Fungal endocarditis after type a dissection, a positive outcome from Candida parapsilosis prosthetic aortic valve endocarditis and aortic graft infection: A testament to multidisciplinary practice

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