Stress hormone rapidly tunes synaptic NMDA receptor through membrane dynamics and mineralocorticoid signalling

Abstract Stress hormones, such as corticosteroids, modulate the transmission of hippocampal glutamatergic synapses and NMDA receptor (NMDAR)-dependent synaptic plasticity, favouring salient behavioural responses to the environment. The corticosterone-induced synaptic adaptations partly rely on chang...

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Autores principales:	Lenka Mikasova, Hui Xiong, Amber Kerkhofs, Delphine Bouchet, Harm J. Krugers, Laurent Groc
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f1810306ce7a4bee8a385cf0fe366aa8
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spelling	oai:doaj.org-article:f1810306ce7a4bee8a385cf0fe366aa82021-12-02T15:05:39ZStress hormone rapidly tunes synaptic NMDA receptor through membrane dynamics and mineralocorticoid signalling10.1038/s41598-017-08695-32045-2322https://doaj.org/article/f1810306ce7a4bee8a385cf0fe366aa82017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08695-3https://doaj.org/toc/2045-2322Abstract Stress hormones, such as corticosteroids, modulate the transmission of hippocampal glutamatergic synapses and NMDA receptor (NMDAR)-dependent synaptic plasticity, favouring salient behavioural responses to the environment. The corticosterone-induced synaptic adaptations partly rely on changes in NMDAR signalling, although the cellular pathway underlying this effect remains elusive. Here, we demonstrate, using single molecule imaging and electrophysiological approaches in hippocampal neurons, that corticosterone specifically controls GluN2B-NMDAR surface dynamics and synaptic content through mineralocorticoid signalling. Strikingly, extracellular corticosterone was sufficient to increase the trapping of GluN2B-NMDAR within synapses. Functionally, corticosterone-induced potentiation of AMPA receptor content in synapses required the changes in NMDAR surface dynamics. These high-resolution imaging data unveiled that, in hippocampal networks, corticosterone is a natural, potent, fast and specific regulator of GluN2B-NMDAR membrane trafficking, tuning NMDAR-dependent synaptic adaptations.Lenka MikasovaHui XiongAmber KerkhofsDelphine BouchetHarm J. KrugersLaurent GrocNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lenka Mikasova Hui Xiong Amber Kerkhofs Delphine Bouchet Harm J. Krugers Laurent Groc Stress hormone rapidly tunes synaptic NMDA receptor through membrane dynamics and mineralocorticoid signalling
description	Abstract Stress hormones, such as corticosteroids, modulate the transmission of hippocampal glutamatergic synapses and NMDA receptor (NMDAR)-dependent synaptic plasticity, favouring salient behavioural responses to the environment. The corticosterone-induced synaptic adaptations partly rely on changes in NMDAR signalling, although the cellular pathway underlying this effect remains elusive. Here, we demonstrate, using single molecule imaging and electrophysiological approaches in hippocampal neurons, that corticosterone specifically controls GluN2B-NMDAR surface dynamics and synaptic content through mineralocorticoid signalling. Strikingly, extracellular corticosterone was sufficient to increase the trapping of GluN2B-NMDAR within synapses. Functionally, corticosterone-induced potentiation of AMPA receptor content in synapses required the changes in NMDAR surface dynamics. These high-resolution imaging data unveiled that, in hippocampal networks, corticosterone is a natural, potent, fast and specific regulator of GluN2B-NMDAR membrane trafficking, tuning NMDAR-dependent synaptic adaptations.
format	article
author	Lenka Mikasova Hui Xiong Amber Kerkhofs Delphine Bouchet Harm J. Krugers Laurent Groc
author_facet	Lenka Mikasova Hui Xiong Amber Kerkhofs Delphine Bouchet Harm J. Krugers Laurent Groc
author_sort	Lenka Mikasova
title	Stress hormone rapidly tunes synaptic NMDA receptor through membrane dynamics and mineralocorticoid signalling
title_short	Stress hormone rapidly tunes synaptic NMDA receptor through membrane dynamics and mineralocorticoid signalling
title_full	Stress hormone rapidly tunes synaptic NMDA receptor through membrane dynamics and mineralocorticoid signalling
title_fullStr	Stress hormone rapidly tunes synaptic NMDA receptor through membrane dynamics and mineralocorticoid signalling
title_full_unstemmed	Stress hormone rapidly tunes synaptic NMDA receptor through membrane dynamics and mineralocorticoid signalling
title_sort	stress hormone rapidly tunes synaptic nmda receptor through membrane dynamics and mineralocorticoid signalling
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f1810306ce7a4bee8a385cf0fe366aa8
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Stress hormone rapidly tunes synaptic NMDA receptor through membrane dynamics and mineralocorticoid signalling

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