Brain volumetric measures in alcoholics: a comparison of two segmentation methods

Marlene Oscar-Berman1&ndash;4, Janet Song5,61Department of Psychiatry, 2Department of Neurology, 3Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA; 4VA Boston Healthcare System, Boston, MA, USA; 5Research Scientist Institute, Center for Excellence...

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Autores principales:	Marlene Oscar-Berman, Janet Song
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/f1832997c8364358b1eb1d79e4f9a5c3
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spelling	oai:doaj.org-article:f1832997c8364358b1eb1d79e4f9a5c32021-12-02T03:01:46ZBrain volumetric measures in alcoholics: a comparison of two segmentation methods1176-63281178-2021https://doaj.org/article/f1832997c8364358b1eb1d79e4f9a5c32011-02-01T00:00:00Zhttp://www.dovepress.com/brain-volumetric-measures-in-alcoholics-a-comparison-of-two-segmentati-a6467https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Marlene Oscar-Berman1&ndash;4, Janet Song5,61Department of Psychiatry, 2Department of Neurology, 3Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA; 4VA Boston Healthcare System, Boston, MA, USA; 5Research Scientist Institute, Center for Excellence in Education, Massachusetts Institute of Technology, Cambridge, MA, USA; 6Harvard College, Cambridge, MA, USAAbstract: Measures of regional brain volumes, which can be derived from magnetic resonance imaging (MRI) images by dividing a brain into its constituent parts, can be used as structural indicators of many different neuroanatomical diseases and disorders, including alcoholism. Reducing the time and cost required for brain segmentation would greatly facilitate both clinical and research endeavors. In the present study, we compared two segmentation methods to measure brain volumes in alcoholic and nonalcoholic control subjects: 1) an automated system (FreeSurfer) and 2) a semi-automated, supervised system (Cardviews, developed by the Center for Morphometric Analysis [CMA] at Massachusetts General Hospital), which requires extensive staff and oversight. The participants included 32 abstinent alcoholics (19 women) and 37 demographically matched, nonalcoholic controls (17 women). Brain scans were acquired in a 3 Tesla MRI scanner. The FreeSurfer and CMA methods showed good agreement for the lateral ventricles, cerebral white matter, caudate, and thalamus. In general, the larger the brain structure, the closer the agreement between the methods, except for the cerebral cortex, which showed large between-method differences. However, several other discrepancies existed between the FreeSurfer and CMA volume measures of alcoholics&rsquo; brains. The CMA volumes, but not FreeSurfer, demonstrated that the thalamus, caudate, and putamen were significantly smaller in male alcoholics as compared with male controls. Additionally, the hippocampus was significantly smaller in alcoholic women compared with women controls. In general, correlation between methods was lowest in male alcoholic subjects, who also showed the greatest abnormalities. These results suggest that although many brain structures can be segmented reliably by CMA and FreeSurfer, low correlations between methods in some regions may be due to morphological changes in the brains of alcoholics.Keywords: alcoholism, MRI, brain segmentation Marlene Oscar-BermanJanet SongDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2011, Iss default, Pp 65-75 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Marlene Oscar-Berman Janet Song Brain volumetric measures in alcoholics: a comparison of two segmentation methods
description	Marlene Oscar-Berman1&ndash;4, Janet Song5,61Department of Psychiatry, 2Department of Neurology, 3Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA; 4VA Boston Healthcare System, Boston, MA, USA; 5Research Scientist Institute, Center for Excellence in Education, Massachusetts Institute of Technology, Cambridge, MA, USA; 6Harvard College, Cambridge, MA, USAAbstract: Measures of regional brain volumes, which can be derived from magnetic resonance imaging (MRI) images by dividing a brain into its constituent parts, can be used as structural indicators of many different neuroanatomical diseases and disorders, including alcoholism. Reducing the time and cost required for brain segmentation would greatly facilitate both clinical and research endeavors. In the present study, we compared two segmentation methods to measure brain volumes in alcoholic and nonalcoholic control subjects: 1) an automated system (FreeSurfer) and 2) a semi-automated, supervised system (Cardviews, developed by the Center for Morphometric Analysis [CMA] at Massachusetts General Hospital), which requires extensive staff and oversight. The participants included 32 abstinent alcoholics (19 women) and 37 demographically matched, nonalcoholic controls (17 women). Brain scans were acquired in a 3 Tesla MRI scanner. The FreeSurfer and CMA methods showed good agreement for the lateral ventricles, cerebral white matter, caudate, and thalamus. In general, the larger the brain structure, the closer the agreement between the methods, except for the cerebral cortex, which showed large between-method differences. However, several other discrepancies existed between the FreeSurfer and CMA volume measures of alcoholics&rsquo; brains. The CMA volumes, but not FreeSurfer, demonstrated that the thalamus, caudate, and putamen were significantly smaller in male alcoholics as compared with male controls. Additionally, the hippocampus was significantly smaller in alcoholic women compared with women controls. In general, correlation between methods was lowest in male alcoholic subjects, who also showed the greatest abnormalities. These results suggest that although many brain structures can be segmented reliably by CMA and FreeSurfer, low correlations between methods in some regions may be due to morphological changes in the brains of alcoholics.Keywords: alcoholism, MRI, brain segmentation
format	article
author	Marlene Oscar-Berman Janet Song
author_facet	Marlene Oscar-Berman Janet Song
author_sort	Marlene Oscar-Berman
title	Brain volumetric measures in alcoholics: a comparison of two segmentation methods
title_short	Brain volumetric measures in alcoholics: a comparison of two segmentation methods
title_full	Brain volumetric measures in alcoholics: a comparison of two segmentation methods
title_fullStr	Brain volumetric measures in alcoholics: a comparison of two segmentation methods
title_full_unstemmed	Brain volumetric measures in alcoholics: a comparison of two segmentation methods
title_sort	brain volumetric measures in alcoholics: a comparison of two segmentation methods
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/f1832997c8364358b1eb1d79e4f9a5c3
work_keys_str_mv	AT marleneoscarberman brainvolumetricmeasuresinalcoholicsacomparisonoftwosegmentationmethods AT janetsong brainvolumetricmeasuresinalcoholicsacomparisonoftwosegmentationmethods
_version_	1718402016182534144

Brain volumetric measures in alcoholics: a comparison of two segmentation methods

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