The role of Toll-like receptors (TLRs) in virus-related cancers: a mini review

The modulation of the host innate immune system is a well-established carcinogenesis feature of several tumors, including human Epstein-Barr (EBV) and Papillomavirus-(HPV) related cancers. These viruses are able to interrupt the initial events of the immune response, including the expression of Toll...

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Autores principales:	Dworzanska Anna, Polz-Dacewicz Małgorzata
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2020
Materias:	tlr9 ebv hpv nasopharyngeal cancer gastric cancer Medicine R
Acceso en línea:	https://doaj.org/article/f184d481fde244f199d59efd73f1847f
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spelling	oai:doaj.org-article:f184d481fde244f199d59efd73f1847f2021-12-05T14:11:06ZThe role of Toll-like receptors (TLRs) in virus-related cancers: a mini review2300-667610.2478/cipms-2020-0038https://doaj.org/article/f184d481fde244f199d59efd73f1847f2020-12-01T00:00:00Zhttps://doi.org/10.2478/cipms-2020-0038https://doaj.org/toc/2300-6676The modulation of the host innate immune system is a well-established carcinogenesis feature of several tumors, including human Epstein-Barr (EBV) and Papillomavirus-(HPV) related cancers. These viruses are able to interrupt the initial events of the immune response, including the expression of Toll-like receptors (TLRs), cytokines, and inflammation. The aim of the study is to review current data and summarize knowledge on the TLRs and their role in the development of cancer, especially viral-related cancers (EBV and HPV). Research work shows a correlation between the TLRs polymorphism and the development of oropharyngeal and gastric cancer (GC), especially related to viral infections. Many studies suggest the important role for TLRs in inflammatory, autoimmune disease and human cancers. However, further efforts are necessary to draw a precise conclusion.Dworzanska AnnaPolz-Dacewicz MałgorzataSciendoarticletlr9ebvhpvnasopharyngeal cancergastric cancerMedicineRENCurrent Issues in Pharmacy and Medical Sciences, Vol 33, Iss 4, Pp 225-227 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	tlr9 ebv hpv nasopharyngeal cancer gastric cancer Medicine R
spellingShingle	tlr9 ebv hpv nasopharyngeal cancer gastric cancer Medicine R Dworzanska Anna Polz-Dacewicz Małgorzata The role of Toll-like receptors (TLRs) in virus-related cancers: a mini review
description	The modulation of the host innate immune system is a well-established carcinogenesis feature of several tumors, including human Epstein-Barr (EBV) and Papillomavirus-(HPV) related cancers. These viruses are able to interrupt the initial events of the immune response, including the expression of Toll-like receptors (TLRs), cytokines, and inflammation. The aim of the study is to review current data and summarize knowledge on the TLRs and their role in the development of cancer, especially viral-related cancers (EBV and HPV). Research work shows a correlation between the TLRs polymorphism and the development of oropharyngeal and gastric cancer (GC), especially related to viral infections. Many studies suggest the important role for TLRs in inflammatory, autoimmune disease and human cancers. However, further efforts are necessary to draw a precise conclusion.
format	article
author	Dworzanska Anna Polz-Dacewicz Małgorzata
author_facet	Dworzanska Anna Polz-Dacewicz Małgorzata
author_sort	Dworzanska Anna
title	The role of Toll-like receptors (TLRs) in virus-related cancers: a mini review
title_short	The role of Toll-like receptors (TLRs) in virus-related cancers: a mini review
title_full	The role of Toll-like receptors (TLRs) in virus-related cancers: a mini review
title_fullStr	The role of Toll-like receptors (TLRs) in virus-related cancers: a mini review
title_full_unstemmed	The role of Toll-like receptors (TLRs) in virus-related cancers: a mini review
title_sort	role of toll-like receptors (tlrs) in virus-related cancers: a mini review
publisher	Sciendo
publishDate	2020
url	https://doaj.org/article/f184d481fde244f199d59efd73f1847f
work_keys_str_mv	AT dworzanskaanna theroleoftolllikereceptorstlrsinvirusrelatedcancersaminireview AT polzdacewiczmałgorzata theroleoftolllikereceptorstlrsinvirusrelatedcancersaminireview AT dworzanskaanna roleoftolllikereceptorstlrsinvirusrelatedcancersaminireview AT polzdacewiczmałgorzata roleoftolllikereceptorstlrsinvirusrelatedcancersaminireview
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The role of Toll-like receptors (TLRs) in virus-related cancers: a mini review

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