Impaired wakefulness and rapid eye movement sleep in dopamine-deficient mice

Abstract Despite the established roles of the dopaminergic system in promoting arousal, the effects of loss of dopamine on the patterns of sleep and wakefulness remain elusive. Here, we examined the sleep architecture of dopamine-deficient (DD) mice, which were previously developed by global knockou...

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Autores principales:	Mitsuaki Kashiwagi, Mika Kanuka, Kaeko Tanaka, Masayo Fujita, Ayaka Nakai, Chika Tatsuzawa, Kazuto Kobayashi, Kazutaka Ikeda, Yu Hayashi
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Dopamine Mouse NREM sleep REM sleep Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/f185785df9594fc2a899c8013e7919f3
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spelling	oai:doaj.org-article:f185785df9594fc2a899c8013e7919f32021-11-21T12:41:51ZImpaired wakefulness and rapid eye movement sleep in dopamine-deficient mice10.1186/s13041-021-00879-31756-6606https://doaj.org/article/f185785df9594fc2a899c8013e7919f32021-11-01T00:00:00Zhttps://doi.org/10.1186/s13041-021-00879-3https://doaj.org/toc/1756-6606Abstract Despite the established roles of the dopaminergic system in promoting arousal, the effects of loss of dopamine on the patterns of sleep and wakefulness remain elusive. Here, we examined the sleep architecture of dopamine-deficient (DD) mice, which were previously developed by global knockout of tyrosine hydroxylase and its specific rescue in noradrenergic and adrenergic neurons. We found that DD mice have reduced time spent in wakefulness. Unexpectedly, DD mice also exhibited a marked reduction in the time spent in rapid eye movement (REM) sleep. The electroencephalogram power spectrum of all vigilance states in DD mice were also affected. These results support the current understanding of the critical roles of the dopaminergic system in maintaining wakefulness and also implicate its previously unknown effects on REM sleep.Mitsuaki KashiwagiMika KanukaKaeko TanakaMasayo FujitaAyaka NakaiChika TatsuzawaKazuto KobayashiKazutaka IkedaYu HayashiBMCarticleDopamineMouseNREM sleepREM sleepNeurology. Diseases of the nervous systemRC346-429ENMolecular Brain, Vol 14, Iss 1, Pp 1-4 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Dopamine Mouse NREM sleep REM sleep Neurology. Diseases of the nervous system RC346-429
spellingShingle	Dopamine Mouse NREM sleep REM sleep Neurology. Diseases of the nervous system RC346-429 Mitsuaki Kashiwagi Mika Kanuka Kaeko Tanaka Masayo Fujita Ayaka Nakai Chika Tatsuzawa Kazuto Kobayashi Kazutaka Ikeda Yu Hayashi Impaired wakefulness and rapid eye movement sleep in dopamine-deficient mice
description	Abstract Despite the established roles of the dopaminergic system in promoting arousal, the effects of loss of dopamine on the patterns of sleep and wakefulness remain elusive. Here, we examined the sleep architecture of dopamine-deficient (DD) mice, which were previously developed by global knockout of tyrosine hydroxylase and its specific rescue in noradrenergic and adrenergic neurons. We found that DD mice have reduced time spent in wakefulness. Unexpectedly, DD mice also exhibited a marked reduction in the time spent in rapid eye movement (REM) sleep. The electroencephalogram power spectrum of all vigilance states in DD mice were also affected. These results support the current understanding of the critical roles of the dopaminergic system in maintaining wakefulness and also implicate its previously unknown effects on REM sleep.
format	article
author	Mitsuaki Kashiwagi Mika Kanuka Kaeko Tanaka Masayo Fujita Ayaka Nakai Chika Tatsuzawa Kazuto Kobayashi Kazutaka Ikeda Yu Hayashi
author_facet	Mitsuaki Kashiwagi Mika Kanuka Kaeko Tanaka Masayo Fujita Ayaka Nakai Chika Tatsuzawa Kazuto Kobayashi Kazutaka Ikeda Yu Hayashi
author_sort	Mitsuaki Kashiwagi
title	Impaired wakefulness and rapid eye movement sleep in dopamine-deficient mice
title_short	Impaired wakefulness and rapid eye movement sleep in dopamine-deficient mice
title_full	Impaired wakefulness and rapid eye movement sleep in dopamine-deficient mice
title_fullStr	Impaired wakefulness and rapid eye movement sleep in dopamine-deficient mice
title_full_unstemmed	Impaired wakefulness and rapid eye movement sleep in dopamine-deficient mice
title_sort	impaired wakefulness and rapid eye movement sleep in dopamine-deficient mice
publisher	BMC
publishDate	2021
url	https://doaj.org/article/f185785df9594fc2a899c8013e7919f3
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Impaired wakefulness and rapid eye movement sleep in dopamine-deficient mice

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