Silymarin nanoparticle prevents paracetamol-induced hepatotoxicity

Suvadra Das, Partha Roy, Runa Ghosh Auddy, Arup MukherjeeDepartment of Chemical Technology, University of Calcutta, Kolkata, West Bengal, IndiaAbstract: Silymarin (Sm) is a polyphenolic component extracted from Silybum marianum. It is an antioxidant, traditionally used as an immunostimulant, hepatop...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Das S, Roy P, Auddy RG, Mukherjee A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f1865780d3a44bf3ac9fde8c1150b257
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f1865780d3a44bf3ac9fde8c1150b257
record_format	dspace
spelling	oai:doaj.org-article:f1865780d3a44bf3ac9fde8c1150b2572021-12-02T02:11:17ZSilymarin nanoparticle prevents paracetamol-induced hepatotoxicity1176-91141178-2013https://doaj.org/article/f1865780d3a44bf3ac9fde8c1150b2572011-06-01T00:00:00Zhttp://www.dovepress.com/silymarin-nanoparticle-prevents-paracetamol-induced-hepatotoxicity-a7706https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Suvadra Das, Partha Roy, Runa Ghosh Auddy, Arup MukherjeeDepartment of Chemical Technology, University of Calcutta, Kolkata, West Bengal, IndiaAbstract: Silymarin (Sm) is a polyphenolic component extracted from Silybum marianum. It is an antioxidant, traditionally used as an immunostimulant, hepatoprotectant, and dietary supplement. Relatively recently, Sm has proved to be a valuable chemopreventive and a useful antineoplastic agent. Medical success for Sm is, however, constrained by very low aqueous solubility and associated biopharmaceutical limitations. Sm flavonolignans are also susceptible to ion-catalyzed degradation in the gut. Proven antihepatotoxic activity of Sm cannot therefore be fully exploited in acute chemical poisoning conditions like that in paracetamol overdose. Moreover, a synchronous delivery that is required for hepatic regeneration is difficult to achieve by itself. This work is meant to circumvent the inherent limitations of Sm through the use of nanotechnology. Sm nanoparticles (Smnps) were prepared by nanoprecipitation in polyvinyl alcohol stabilized Eudragit RS100&reg; polymer (Rohm Pharma GmbH, Darmstadt, Germany). Process parameter optimization provided 67.39% entrapment efficiency and a Gaussian particle distribution of average size 120.37 nm. Sm release from the nanoparticles was considerably sustained for all formulations. Smnps were strongly protective against hepatic damage when tested in a paracetamol overdose hepatotoxicity model. Nanoparticles recorded no animal death even when administered after an established paracetamol-induced hepatic necrosis. Preventing progress of paracetamol hepatic damage was traced for an efficient glutathione regeneration to a level of 11.3 &micro;mol/g in hepatic tissue due to Smnps.Keywords: silymarin, paracetamol, nanoparticle, glutathione, mouse hepatotoxicityDas SRoy PAuddy RGMukherjee ADove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 1291-1301 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Das S Roy P Auddy RG Mukherjee A Silymarin nanoparticle prevents paracetamol-induced hepatotoxicity
description	Suvadra Das, Partha Roy, Runa Ghosh Auddy, Arup MukherjeeDepartment of Chemical Technology, University of Calcutta, Kolkata, West Bengal, IndiaAbstract: Silymarin (Sm) is a polyphenolic component extracted from Silybum marianum. It is an antioxidant, traditionally used as an immunostimulant, hepatoprotectant, and dietary supplement. Relatively recently, Sm has proved to be a valuable chemopreventive and a useful antineoplastic agent. Medical success for Sm is, however, constrained by very low aqueous solubility and associated biopharmaceutical limitations. Sm flavonolignans are also susceptible to ion-catalyzed degradation in the gut. Proven antihepatotoxic activity of Sm cannot therefore be fully exploited in acute chemical poisoning conditions like that in paracetamol overdose. Moreover, a synchronous delivery that is required for hepatic regeneration is difficult to achieve by itself. This work is meant to circumvent the inherent limitations of Sm through the use of nanotechnology. Sm nanoparticles (Smnps) were prepared by nanoprecipitation in polyvinyl alcohol stabilized Eudragit RS100&reg; polymer (Rohm Pharma GmbH, Darmstadt, Germany). Process parameter optimization provided 67.39% entrapment efficiency and a Gaussian particle distribution of average size 120.37 nm. Sm release from the nanoparticles was considerably sustained for all formulations. Smnps were strongly protective against hepatic damage when tested in a paracetamol overdose hepatotoxicity model. Nanoparticles recorded no animal death even when administered after an established paracetamol-induced hepatic necrosis. Preventing progress of paracetamol hepatic damage was traced for an efficient glutathione regeneration to a level of 11.3 &micro;mol/g in hepatic tissue due to Smnps.Keywords: silymarin, paracetamol, nanoparticle, glutathione, mouse hepatotoxicity
format	article
author	Das S Roy P Auddy RG Mukherjee A
author_facet	Das S Roy P Auddy RG Mukherjee A
author_sort	Das S
title	Silymarin nanoparticle prevents paracetamol-induced hepatotoxicity
title_short	Silymarin nanoparticle prevents paracetamol-induced hepatotoxicity
title_full	Silymarin nanoparticle prevents paracetamol-induced hepatotoxicity
title_fullStr	Silymarin nanoparticle prevents paracetamol-induced hepatotoxicity
title_full_unstemmed	Silymarin nanoparticle prevents paracetamol-induced hepatotoxicity
title_sort	silymarin nanoparticle prevents paracetamol-induced hepatotoxicity
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/f1865780d3a44bf3ac9fde8c1150b257
work_keys_str_mv	AT dass silymarinnanoparticlepreventsparacetamolinducedhepatotoxicity AT royp silymarinnanoparticlepreventsparacetamolinducedhepatotoxicity AT auddyrg silymarinnanoparticlepreventsparacetamolinducedhepatotoxicity AT mukherjeea silymarinnanoparticlepreventsparacetamolinducedhepatotoxicity
_version_	1718402686538219520

Silymarin nanoparticle prevents paracetamol-induced hepatotoxicity

Ejemplares similares