KRAS and NRAS genes mutations as biomarkers in the therapy of colorectal cancer and the basic methods of their detection

Determination of the mutations' status in the KRAS and NRAS genes is a necessary requirement in the treatment of patients with colorectal cancer (CRC). Patients with certain mutations in the KRAS and NRAS genes are resistant to anti-EGFR drug therapy and have a lower median survival rate than t...

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Autores principales:	Olga I. Brovkina, Alexey G. Nikitin
Formato:	article
Lenguaje:	RU
Publicado:	Eco-vector 2021
Materias:	colorectal cancer mutations in the kras, nras genes biomarkers circulating tumor dna Medicine R
Acceso en línea:	https://doaj.org/article/f188be48a67348c79d1798ffd8d2b72d
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spelling	oai:doaj.org-article:f188be48a67348c79d1798ffd8d2b72d2021-11-30T18:15:21ZKRAS and NRAS genes mutations as biomarkers in the therapy of colorectal cancer and the basic methods of their detection2220-30952618-862710.17816/clinpract63875https://doaj.org/article/f188be48a67348c79d1798ffd8d2b72d2021-03-01T00:00:00Zhttps://journals.eco-vector.com/clinpractice/article/viewFile/63875/pdfhttps://doaj.org/toc/2220-3095https://doaj.org/toc/2618-8627Determination of the mutations' status in the KRAS and NRAS genes is a necessary requirement in the treatment of patients with colorectal cancer (CRC). Patients with certain mutations in the KRAS and NRAS genes are resistant to anti-EGFR drug therapy and have a lower median survival rate than those with WT (wild type) genotypes, that indicates a negative prognosis in the case when mutations are present. Currently, there are no registered targeted drugs for carriers of the KRAS and NRAS genes mutations, however, preparations based on small molecules are under way. The gold standard for detecting mutations in the KRAS and NRAS genes is the analysis of the biopsy material in paraffin blocks. However, this method has significant limitations that can be circumvented by the analysis of circulating tumor DNA a promising new method in the diagnosis of colorectal cancer.Olga I. BrovkinaAlexey G. NikitinEco-vectorarticlecolorectal cancermutations in the kras, nras genesbiomarkerscirculating tumor dnaMedicineRRUКлиническая практика , Vol 12, Iss 1, Pp 66-71 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	colorectal cancer mutations in the kras, nras genes biomarkers circulating tumor dna Medicine R
spellingShingle	colorectal cancer mutations in the kras, nras genes biomarkers circulating tumor dna Medicine R Olga I. Brovkina Alexey G. Nikitin KRAS and NRAS genes mutations as biomarkers in the therapy of colorectal cancer and the basic methods of their detection
description	Determination of the mutations' status in the KRAS and NRAS genes is a necessary requirement in the treatment of patients with colorectal cancer (CRC). Patients with certain mutations in the KRAS and NRAS genes are resistant to anti-EGFR drug therapy and have a lower median survival rate than those with WT (wild type) genotypes, that indicates a negative prognosis in the case when mutations are present. Currently, there are no registered targeted drugs for carriers of the KRAS and NRAS genes mutations, however, preparations based on small molecules are under way. The gold standard for detecting mutations in the KRAS and NRAS genes is the analysis of the biopsy material in paraffin blocks. However, this method has significant limitations that can be circumvented by the analysis of circulating tumor DNA a promising new method in the diagnosis of colorectal cancer.
format	article
author	Olga I. Brovkina Alexey G. Nikitin
author_facet	Olga I. Brovkina Alexey G. Nikitin
author_sort	Olga I. Brovkina
title	KRAS and NRAS genes mutations as biomarkers in the therapy of colorectal cancer and the basic methods of their detection
title_short	KRAS and NRAS genes mutations as biomarkers in the therapy of colorectal cancer and the basic methods of their detection
title_full	KRAS and NRAS genes mutations as biomarkers in the therapy of colorectal cancer and the basic methods of their detection
title_fullStr	KRAS and NRAS genes mutations as biomarkers in the therapy of colorectal cancer and the basic methods of their detection
title_full_unstemmed	KRAS and NRAS genes mutations as biomarkers in the therapy of colorectal cancer and the basic methods of their detection
title_sort	kras and nras genes mutations as biomarkers in the therapy of colorectal cancer and the basic methods of their detection
publisher	Eco-vector
publishDate	2021
url	https://doaj.org/article/f188be48a67348c79d1798ffd8d2b72d
work_keys_str_mv	AT olgaibrovkina krasandnrasgenesmutationsasbiomarkersinthetherapyofcolorectalcancerandthebasicmethodsoftheirdetection AT alexeygnikitin krasandnrasgenesmutationsasbiomarkersinthetherapyofcolorectalcancerandthebasicmethodsoftheirdetection
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KRAS and NRAS genes mutations as biomarkers in the therapy of colorectal cancer and the basic methods of their detection

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