Circulating miR-21, miR-29a, and miR-126 are associated with premature death risk due to cancer and cardiovascular disease: the JACC Study

Abstract Primary prevention of premature death is a public health concern worldwide. Circulating microRNAs (miRNAs) have been described as potential diagnostic biomarkers for diseases as cancer and cardiovascular disease (CVD). This case-cohort study aimed to investigate the potential relationship b...

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Autores principales:	Hiroya Yamada, Koji Suzuki, Ryosuke Fujii, Miyuki Kawado, Shuji Hashimoto, Yoshiyuki Watanabe, Hiroyasu Iso, Yoshihisa Fujino, Kenji Wakai, Akiko Tamakoshi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f188feb062c74292bdaa4fd1fe9bc9dd
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spelling	oai:doaj.org-article:f188feb062c74292bdaa4fd1fe9bc9dd2021-12-02T11:35:58ZCirculating miR-21, miR-29a, and miR-126 are associated with premature death risk due to cancer and cardiovascular disease: the JACC Study10.1038/s41598-021-84707-72045-2322https://doaj.org/article/f188feb062c74292bdaa4fd1fe9bc9dd2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84707-7https://doaj.org/toc/2045-2322Abstract Primary prevention of premature death is a public health concern worldwide. Circulating microRNAs (miRNAs) have been described as potential diagnostic biomarkers for diseases as cancer and cardiovascular disease (CVD). This case-cohort study aimed to investigate the potential relationship between circulating miRNAs and the risk of premature death. A total of 39,242 subjects provided baseline serum samples in 1988–1990. Of these, 345 subjects who died of intrinsic disease (< 65 years old) and for which measurable samples were available were included in this study. We randomly selected a sub-cohort of 879 subjects. Circulatring miR-21, miR-29a, and miR-126 were determined using qRT-PCR. Conditional logistic regression models were used to analyse the data with respect to stratified miRNA levels. Multivariable logistic regression revealed that subjects with high circulating miR-21 and miR-29a individual levels had a significantly higher risk of total death, cancer death, and CVD death than those with medium miR-21 and miR-29a individual levels. Conversely, subjects with low circulating miR-126 levels had a significantly higher risk of total death than those with medium levels. This suggests that circulating miRNAs are associated with the risk of premature death from cancer and CVD, identifying them as potential biomarkers for early detection of high-risk individuals.Hiroya YamadaKoji SuzukiRyosuke FujiiMiyuki KawadoShuji HashimotoYoshiyuki WatanabeHiroyasu IsoYoshihisa FujinoKenji WakaiAkiko TamakoshiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hiroya Yamada Koji Suzuki Ryosuke Fujii Miyuki Kawado Shuji Hashimoto Yoshiyuki Watanabe Hiroyasu Iso Yoshihisa Fujino Kenji Wakai Akiko Tamakoshi Circulating miR-21, miR-29a, and miR-126 are associated with premature death risk due to cancer and cardiovascular disease: the JACC Study
description	Abstract Primary prevention of premature death is a public health concern worldwide. Circulating microRNAs (miRNAs) have been described as potential diagnostic biomarkers for diseases as cancer and cardiovascular disease (CVD). This case-cohort study aimed to investigate the potential relationship between circulating miRNAs and the risk of premature death. A total of 39,242 subjects provided baseline serum samples in 1988–1990. Of these, 345 subjects who died of intrinsic disease (< 65 years old) and for which measurable samples were available were included in this study. We randomly selected a sub-cohort of 879 subjects. Circulatring miR-21, miR-29a, and miR-126 were determined using qRT-PCR. Conditional logistic regression models were used to analyse the data with respect to stratified miRNA levels. Multivariable logistic regression revealed that subjects with high circulating miR-21 and miR-29a individual levels had a significantly higher risk of total death, cancer death, and CVD death than those with medium miR-21 and miR-29a individual levels. Conversely, subjects with low circulating miR-126 levels had a significantly higher risk of total death than those with medium levels. This suggests that circulating miRNAs are associated with the risk of premature death from cancer and CVD, identifying them as potential biomarkers for early detection of high-risk individuals.
format	article
author	Hiroya Yamada Koji Suzuki Ryosuke Fujii Miyuki Kawado Shuji Hashimoto Yoshiyuki Watanabe Hiroyasu Iso Yoshihisa Fujino Kenji Wakai Akiko Tamakoshi
author_facet	Hiroya Yamada Koji Suzuki Ryosuke Fujii Miyuki Kawado Shuji Hashimoto Yoshiyuki Watanabe Hiroyasu Iso Yoshihisa Fujino Kenji Wakai Akiko Tamakoshi
author_sort	Hiroya Yamada
title	Circulating miR-21, miR-29a, and miR-126 are associated with premature death risk due to cancer and cardiovascular disease: the JACC Study
title_short	Circulating miR-21, miR-29a, and miR-126 are associated with premature death risk due to cancer and cardiovascular disease: the JACC Study
title_full	Circulating miR-21, miR-29a, and miR-126 are associated with premature death risk due to cancer and cardiovascular disease: the JACC Study
title_fullStr	Circulating miR-21, miR-29a, and miR-126 are associated with premature death risk due to cancer and cardiovascular disease: the JACC Study
title_full_unstemmed	Circulating miR-21, miR-29a, and miR-126 are associated with premature death risk due to cancer and cardiovascular disease: the JACC Study
title_sort	circulating mir-21, mir-29a, and mir-126 are associated with premature death risk due to cancer and cardiovascular disease: the jacc study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f188feb062c74292bdaa4fd1fe9bc9dd
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Circulating miR-21, miR-29a, and miR-126 are associated with premature death risk due to cancer and cardiovascular disease: the JACC Study

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